Discovery and Study of the Binding Epitopes of Novel Urease Inhibitors by STD-NMR Spectroscopy and Biochemical Analyses

2013 ◽  
Vol 10 (6) ◽  
pp. 515-521 ◽  
Author(s):  
Atia-tul- Wahab ◽  
Ajmal Khan ◽  
Bishnu P. Marasini ◽  
M. Arif Lodhi ◽  
Atta-ur- Rahman ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Urease Inhibitors ◽  
Std Nmr ◽  
Biochemical Analyses

Studies on new urease inhibitors by using biochemical, STD-NMR spectroscopy, and molecular docking methods

2017 ◽  
Vol 26 (10) ◽  
pp. 2452-2467 ◽  
Author(s):  
Jalaluddin A. Khan ◽  
Atia-tul- Wahab ◽  
Sumaira Javaid ◽  
Maryam AL-Ghamdi ◽  
Etimad Huwait ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Nmr Spectroscopy ◽  
Urease Inhibitors ◽  
Std Nmr

Study of Binding Epitopes by STD-NMR Spectroscopy and Molecular Docking of Urease Inhibitors from Lichens

2016 ◽  
Vol 13 (4) ◽  
pp. 282-294 ◽  
Author(s):  
Vinitha Moolchand Thadhani ◽  
Ajmal Khan ◽  
. Atia-tul-Wahab ◽  
Sumaira Javaid ◽  
Amsal Shafqat ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Nmr Spectroscopy ◽  
Urease Inhibitors ◽  
Std Nmr

Avian Influenza H5-Containing Virus-Like Particles (VLPs): Host-Cell Receptor Specificity by STD NMR Spectroscopy

2008 ◽  
Vol 120 (10) ◽  
pp. 1936-1938 ◽  
Author(s):  
Thomas Haselhorst ◽  
Jean-Michel Garcia ◽  
Tasneem Islam ◽  
Jimmy C. C. Lai ◽  
Faith J. Rose ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Avian Influenza ◽  
Host Cell ◽  
Cell Receptor ◽  
Receptor Specificity ◽  
Virus Like Particles ◽  
Host Cell Receptor ◽  
Std Nmr

Examining Binding to Nanoparticle Surfaces Using Saturation Transfer Difference (STD)-NMR Spectroscopy

2017 ◽  
Vol 121 (44) ◽  
pp. 24678-24686 ◽  
Author(s):  
Yunzhi Zhang ◽  
Hui Xu ◽  
Austin M. Parsons ◽  
Leah B. Casabianca
Keyword(s):  
Nmr Spectroscopy ◽  
Saturation Transfer ◽  
Saturation Transfer Difference ◽  
Std Nmr

Avian Influenza H5-Containing Virus-Like Particles (VLPs): Host-Cell Receptor Specificity by STD NMR Spectroscopy

2008 ◽  
Vol 47 (10) ◽  
pp. 1910-1912 ◽  
Author(s):  
Thomas Haselhorst ◽  
Jean-Michel Garcia ◽  
Tasneem Islam ◽  
Jimmy C. C. Lai ◽  
Faith J. Rose ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Avian Influenza ◽  
Host Cell ◽  
Cell Receptor ◽  
Receptor Specificity ◽  
Virus Like Particles ◽  
Host Cell Receptor ◽  
Std Nmr

scholarly journals Investigation of Binding of UDP-Galfand UDP-[3-F]Galfto UDP-galactopyranose Mutase by STD-NMR Spectroscopy, Molecular Dynamics, and CORCEMA-ST Calculations†

2008 ◽  
Vol 130 (10) ◽  
pp. 3157-3168 ◽  
Author(s):  
Yue Yuan ◽  
Dustin W. Bleile ◽  
Xin Wen ◽  
David A. R. Sanders ◽  
Kenji Itoh ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Nmr Spectroscopy ◽  
Std Nmr

Screening of Protein Kinases by ATP-STD NMR Spectroscopy

2005 ◽  
Vol 127 (22) ◽  
pp. 7978-7979 ◽  
Author(s):  
Mark A. McCoy ◽  
Mary M. Senior ◽  
Daniel F. Wyss
Keyword(s):  
Nmr Spectroscopy ◽  
Protein Kinases ◽  
Std Nmr

Lectin-Based Drug Design: Combined Strategy to Identify Lead Compounds using STD NMR Spectroscopy, Solid-Phase Assays and Cell Binding for a Plant Toxin Model

ChemMedChem ◽  
2010 ◽  
Vol 5 (3) ◽  
pp. 415-419 ◽  
Author(s):  
João P. Ribeiro ◽  
Sabine André ◽  
F. Javier Cañada ◽  
Hans-Joachim Gabius ◽  
Anna Paola Butera ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Drug Design ◽  
Solid Phase ◽  
Cell Binding ◽  
Plant Toxin ◽  
Lead Compounds ◽  
Std Nmr ◽  
Combined Strategy

scholarly journals STD NMR spectroscopy and molecular modeling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core

Glycobiology ◽  
2006 ◽  
Vol 17 (1) ◽  
pp. 68-81 ◽  
Author(s):  
Thomas Haselhorst ◽  
Helen Blanchard ◽  
Martin Frank ◽  
Mark J. Kraschnefski ◽  
Milton J. Kiefel ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Nmr Spectroscopy ◽  
Acetylneuraminic Acid ◽  
Std Nmr

scholarly journals Spatially Resolved STD-NMR Applied to the Study of Solute Transport in Biphasic Systems: Application to Protein-Ligand Interactions

2019 ◽  
Vol 14 (5) ◽  
pp. 1934578X1984978 ◽  
Author(s):  
Ridvan Nepravishta ◽  
Serena Monaco ◽  
Juan C. Muñoz-García ◽  
Yaroslav Z. Khimyak ◽  
Jesus Angulo
Keyword(s):  
Nmr Spectroscopy ◽  
Solute Exchange ◽  
Spatially Resolved ◽  
Protein Ligand Interactions ◽  
Ligand Interactions ◽  
Std Nmr ◽  
Underlying Mechanisms ◽  
Solute Dynamics ◽  
Pharmacological Screening ◽  
Biphasic Systems

Fluid biphasic systems are one of the most interesting dynamic systems in chemistry and biochemistry. In nuclear magnetic resonance (NMR) spectroscopy, the study of the solute dynamics across fluid biphasic systems requires the introduction of dedicated NMR methods, due to their intrinsic heterogeneity. Diffusion and spatially resolved NMR techniques represent a useful approach for dealing with the study of solutes in biphasic systems and have been applied lately with success. Nevertheless, other potential applications of NMR spectroscopy for biphasic systems remain to be explored. In this proof-of-concept communication, we specifically aimed to investigate whether solute exchange between two immiscible phases can be followed by NMR experiments involving transfer of magnetization. To that aim, we have used spatially resolved saturation transfer difference NMR (SR-STD NMR) experiments to analyze solute exchange by transfer of saturation from one phase to the other in a biphasic system and have explored which are the underlying mechanisms leading to the transfer of magnetization between phases and the limits of the approach. We hereby demonstrate that SR-STD NMR is feasible and that it might be implemented in pharmacological screening for binders of biological receptors or in the study of chemical and biochemical reactions occurring at interfaces.

Sign in / Sign up

Export Citation Format

Share Document