Basic Concepts and Applications of Molecular Topology to Drug Design

2015 ◽  
pp. 161-195
Keyword(s):  
Drug Design ◽  
Molecular Topology ◽  
Basic Concepts

Introduction to Molecular Topology: Basic Concepts and Application to Drug Design

2012 ◽  
Vol 8 (3) ◽  
pp. 196-223 ◽  
Author(s):  
Jorge Galvez ◽  
Maria Galvez-Llompart ◽  
Ramon Garcia-Domenech
Keyword(s):  
Drug Design ◽  
Molecular Topology ◽  
Basic Concepts

On the Contribution of Molecular Topology to Drug Design and Discovery

2010 ◽  
Vol 6 (4) ◽  
pp. 252-268 ◽  
Author(s):  
Jorge Galvez ◽  
Ramon Garcia-Domenech
Keyword(s):  
Drug Design ◽  
Molecular Topology

Ligand potency – an essential estimator for drug design: between intuition, misinterpretation and serendipity

2019 ◽  
Vol 11 (14) ◽  
pp. 1827-1843 ◽  
Author(s):  
Jaroslaw Polanski ◽  
Andrzej Bak
Keyword(s):  
Drug Design ◽  
Research And Development ◽  
Basic Concepts

This is a review of developments in the field of potency, which is an essential estimator for drug design. We discuss the basic concepts of research and discovery, focusing on how misinterpretation in this area, – but also intuition and serendipity, which are common in drug design – helped us to pave a bumpy road towards better drugs. How far we still are from this goal can be seen in the Eroom law, which states that the efficiency of pharma research and development is decreasing. At the same time, pharma bestsellers are getting older.

An Introduction to the Basic Concepts in QSAR-Aided Drug Design

2017 ◽  
pp. 32-78
Author(s):  
Maryam Hamzeh-Mivehroud ◽  
Babak Sokouti ◽  
Siavoush Dastmalchi
Keyword(s):  
Drug Design ◽  
Basic Concepts

scholarly journals Alzheimer: A Decade of Drug Design. Why Molecular Topology can be an Extra Edge?

2018 ◽  
Vol 16 (6) ◽  
pp. 849-864 ◽  
Author(s):  
Riccardo Zanni ◽  
Ramon Garcia-Domenech ◽  
Maria Galvez-Llompart ◽  
Jorge Galvez
Keyword(s):  
Drug Design ◽  
Molecular Topology

scholarly journals Computing Zagreb and Randić Indices of PEG-Cored Dendrimers Used for Drug and Gene Delivery

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Thayamathy Pio Jude ◽  
Elango Panchadcharam ◽  
Koneswaran Masilamani
Keyword(s):  
Gene Delivery ◽  
Drug Design ◽  
Topological Indices ◽  
Randić Index ◽  
Molecular Topology ◽  
Design And Development ◽  
Randic Index ◽  
Zagreb Indices ◽  
Chemical Structures ◽  
Drug And Gene Delivery

Zagreb and Randić indices are the most commonly used degree-based topological indices in the study of drug design and development. In molecular topology, M-polynomials are also used to calculate the degree-based topological indices of chemical structures. In this paper, we derive the M-polynomials for the PEG-cored PAMAM, carbosilane, and poly (lysine) dendrimers and calculate their first, second, and second modified Zagreb indices and the Randić index.

A Cognitive-Linguistic Intervention Program: Basic Concept Formation Level

1977 ◽  
Vol 8 (1) ◽  
pp. 23-32
Author(s):  
Gerald E. Chappell
Keyword(s):  
Basic Concept ◽  
Concept Formation ◽  
Intervention Program ◽  
Cognitive Linguistic ◽  
Basic Concepts ◽  
Linguistic Skills ◽  
Linguistic Intervention

Test-teach questioning is a strategy that can be used to help children develop basic concepts. It fosters the use of multisensory exploration and discovery in learning which leads to the development of cognitive-linguistic skills. This article outlines some of the theoretical bases for this approach and indicates possibilities for their applications in child-clinician transactions.

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