scholarly journals Inflammation amplifier and gateway reflex: The regulation of inflammation by neuroimmune interaction

2017 ◽  
Vol 40 (3) ◽  
pp. 160-168 ◽  
Author(s):  
Ikuma NAKAGAWA ◽  
Masaaki MURAKAMI
Keyword(s):  
Neuroimmune Interaction

scholarly journals Beyond the borders: the gates and fences of neuroimmune interaction

2014 ◽  
Vol 8 ◽  
Author(s):  
Javier Velázquez-Moctezuma ◽  
Emilio Domínguez-Salazar ◽  
Beatriz Gómez-González
Keyword(s):  
Neuroimmune Interaction

scholarly journals Molecular Basis of Neuroimmune Interaction in an In Vitro Coculture Approach

2008 ◽  
Vol 5 (4) ◽  
pp. 249-259 ◽  
Author(s):  
Mamoru Nakanishi ◽  
Tadahide Furuno
Keyword(s):  
Molecular Basis ◽  
Neuroimmune Interaction

A Neuroimmune Interaction in Painful Peripheral Neuropathy

2000 ◽  
Vol 16 (Supplement) ◽  
pp. S139-S143 ◽  
Author(s):  
Gary J. Bennett
Keyword(s):  
Peripheral Neuropathy ◽  
Neuroimmune Interaction

scholarly journals Analgesic Mechanism of Sinomenine against Chronic Pain

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Wei Jiang ◽  
Weiming Fan ◽  
Tianle Gao ◽  
Tao Li ◽  
Zhenming Yin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Pain ◽  
Immune Regulation ◽  
Repeated Administration ◽  
Review Article ◽  
Clinical Settings ◽  
Chronic Pain Management ◽  
Neuroimmune Interaction ◽  
Sinomenium Acutum ◽  
China And Japan

Purified from the roots of the plant Sinomenium acutum, sinomenine is traditionally used in China and Japan for treating rheumatism and arthritis. Previously, we have demonstrated that sinomenine possessed a broad analgesic spectrum in various chronic pain animal models and repeated administration of sinomenine did not generate tolerance. In this review article, we discussed sinomenine’s analgesic mechanism with focus on its role on immune regulation and neuroimmune interaction. Sinomenine has distinct immunoregulative properties, in which glutamate, adenosine triphosphate, nitric oxide, and proinflammatory cytokines are thought to be involved. Sinomenine may alter the unbalanced neuroimmune interaction and inhibit neuroinflammation, oxidative stress, and central sensitization in chronic pain states. In conclusion, sinomenine has promising potential for chronic pain management in different clinical settings.

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