Quantification of Hepatic Iron Deposition in Patients With Liver Disease: Comparison of Chemical Shift Imaging With Single-Echo T2*-Weighted Imaging

2010 ◽  
Vol 194 (5) ◽  
pp. 1288-1295 ◽  
Author(s):  
Ruth P. Lim ◽  
Keren Tuvia ◽  
Cristina H. Hajdu ◽  
Mariela Losada ◽  
Raavi Gupta ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chemical Shift ◽  
Chemical Shift Imaging ◽  
Iron Deposition ◽  
Hepatic Iron

Hepatic Iron Deposition in Patients With Liver Disease: Preliminary Experience With Breath-Hold Multiecho T2*-Weighted Sequence

2009 ◽  
Vol 193 (5) ◽  
pp. 1261-1267 ◽  
Author(s):  
Hersh Chandarana ◽  
Ruth P. Lim ◽  
Jens H. Jensen ◽  
Cristina H. Hajdu ◽  
Mariela Losada ◽  
...  
Keyword(s):  
Liver Disease ◽  
Iron Deposition ◽  
Breath Hold ◽  
Hepatic Iron ◽  
Weighted Sequence

Hepatic iron deposition on MR imaging in patients with chronic liver disease: correlation with serial serum ferritin concentration

2001 ◽  
Vol 26 (2) ◽  
pp. 149-156 ◽  
Author(s):  
M.-J. Kim ◽  
D. G. Mitchell ◽  
K. Ito ◽  
H.-W. L. Hann ◽  
Y. N. Park ◽  
...  
Keyword(s):  
Liver Disease ◽  
Mr Imaging ◽  
Chronic Liver Disease ◽  
Serum Ferritin ◽  
Chronic Liver ◽  
Iron Deposition ◽  
Hepatic Iron ◽  
Ferritin Concentration ◽  
Serum Ferritin Concentration ◽  
Serial Serum

scholarly journals Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease

Hepatology ◽  
2010 ◽  
Vol 53 (2) ◽  
pp. 448-457 ◽  
Author(s):  
James E. Nelson ◽  
Laura Wilson ◽  
Elizabeth M. Brunt ◽  
Matthew M. Yeh ◽  
David E. Kleiner ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Iron Deposition ◽  
Hepatic Iron ◽  
Nonalcoholic Fatty Liver

scholarly journals Spur cell anaemia and hepatic iron stores in patients with alcoholic liver disease undergoing orthotopic liver transplantation

Gut ◽  
1999 ◽  
Vol 45 (2) ◽  
pp. 301-305 ◽  
Author(s):  
A Pascoe ◽  
P Kerlin ◽  
C Steadman ◽  
A Clouston ◽  
D Jones ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Disease ◽  
Orthotopic Liver Transplantation ◽  
Haemolytic Anaemia ◽  
Alcoholic Liver Disease ◽  
Iron Deposition ◽  
Hepatic Iron ◽  
Iron Loading ◽  
Hfe Mutations ◽  
Grade 3

BACKGROUNDFollowing orthotopic liver transplantation (OLT) histological examination of explant livers from patients with alcoholic liver disease (ALD) sometimes shows extensive iron deposits in a distribution suggestive of homozygous haemochromatosis.AIMSTo use haemochromatosis gene (HFE) assays to distinguish between ALD with notable siderosis and hereditary haemochromatosis. To evaluate the possible influence of spur cell haemolytic anaemia on hepatic iron loading.PATIENTSThirty seven patients with ALD were abstinent for at least six months prior to OLT. Twenty three patients had transferrin saturations greater than 55%, 16 also had increased serum ferritin (>350 μg/l). Eight of 37 (22%) explant livers had grade 3 or 4 hepatic iron deposition, predominantly in hepatocytes. Of these, four had a hepatic iron index greater than 1.9 and most seemed to have spur cell haemolytic anaemia.METHODSMutation analysis for C282Y and H63D mutations was performed on DNA extracts from peripheral blood or explant liver. Spur cell haemolytic anaemia was diagnosed when the haemoglobin was 105 g/l in the presence of notable acanthocytosis.RESULTSNone of the eight patients with grade 3 or 4 hepatic iron had evidence of the C282Y mutation. Two of the eight were heterozygous for H63D. None of the remaining 28 patients tested showed homozygous HFE mutations. Spur cell anaemia was present in six of the eight patients with heavy iron deposition and only one of the remaining patients.CONCLUSIONSThe HFE mutation was not present in these patients with advanced ALD and heavy iron loading. Spur cell haemolytic anaemia provides an alternative potential mechanism for the heavy iron loading.

Hepatic iron overload in alcoholic end-stage liver disease is associated with iron deposition in other organs in the absence of HFE-1 hemochromatosis

2005 ◽  
Vol 25 (3) ◽  
pp. 513-517 ◽  
Author(s):  
Sue C. Eng ◽  
Shari L. Taylor ◽  
Victoria Reyes ◽  
Stuart Raaka ◽  
Jose Berger ◽  
...  
Keyword(s):  
Liver Disease ◽  
Iron Overload ◽  
Iron Deposition ◽  
Hepatic Iron ◽  
End Stage Liver Disease ◽  
Hepatic Iron Overload ◽  
End Stage

Sa1047 Increased Hepatic Iron Deposition and Long-Term Prognosis of Patients With Nonalcoholic Fatty Liver Disease

2014 ◽  
Vol 146 (5) ◽  
pp. S-946
Author(s):  
Wesam M. Frandah ◽  
David E. Kleiner ◽  
Sanne Dam-Larsen ◽  
Svanhildur Haflidadottir ◽  
Phunchai Charatcharoenwitthaya ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Iron Deposition ◽  
Hepatic Iron ◽  
Nonalcoholic Fatty Liver ◽  
Long Term Prognosis
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