scholarly journals Hepatic fat quantification using chemical shift MR imaging and MR spectroscopy in the presence of hepatic iron deposition: Validation in phantoms and in patients with chronic liver disease

2011 ◽  
Vol 33 (6) ◽  
pp. 1390-1398 ◽  
Author(s):  
Seung Soo Lee ◽  
Youngjoo Lee ◽  
Namkug Kim ◽  
Seong Who Kim ◽  
Jae Ho Byun ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chemical Shift ◽  
Mr Imaging ◽  
Chronic Liver Disease ◽  
Mr Spectroscopy ◽  
Chronic Liver ◽  
Iron Deposition ◽  
Hepatic Iron ◽  
Fat Quantification ◽  
Hepatic Fat

Hepatic iron deposition on MR imaging in patients with chronic liver disease: correlation with serial serum ferritin concentration

2001 ◽  
Vol 26 (2) ◽  
pp. 149-156 ◽  
Author(s):  
M.-J. Kim ◽  
D. G. Mitchell ◽  
K. Ito ◽  
H.-W. L. Hann ◽  
Y. N. Park ◽  
...  
Keyword(s):  
Liver Disease ◽  
Mr Imaging ◽  
Chronic Liver Disease ◽  
Serum Ferritin ◽  
Chronic Liver ◽  
Iron Deposition ◽  
Hepatic Iron ◽  
Ferritin Concentration ◽  
Serum Ferritin Concentration ◽  
Serial Serum

Pathogenesis, Diagnosis and Treatment of Hemochromatosis

2016 ◽  
Vol 34 (4) ◽  
pp. 364-373 ◽  
Author(s):  
Heinz Zoller ◽  
Benjamin Henninger
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Transferrin Saturation ◽  
Chronic Liver ◽  
Diagnosis And Treatment ◽  
Alternative View ◽  
Hepatic Iron ◽  
Iron Storage ◽  
Non Invasive ◽  
Tissue Iron

Hemochromatosis is a common cause of chronic liver disease and HFE genotyping allows decisive and non-invasive diagnosis. Molecular and clinical genetic studies have led to the identification of genes other than HFE in patients with inherited diseases associated with increased hepatic iron storage that can cause hemochromatosis, which adds complexity to a diagnostic approach to patients with suspected hemochromatosis. Despite major advances in genetics, hepatic iron quantification by non-invasive methods therefore remains the key to the diagnosis of hemochromatosis. Although associated with homozygosity for the C282Y polymorphism in the HFE gene in >80% of patients, hemochromatosis is a complex genetic disease with strong environmental disease modifiers. Testing for mutations in the non-HFE hemochromatosis genes transferrin receptor 2, hemojuvelin, HAMP and SLC40A1 is complex, costly and time-consuming. Demonstration of hepatic iron overload by liver biopsy or MRI is therefore required before such complex tests are carried out. The pathogenesis of chronic liver disease in hemochromatosis is mainly attributed to the redox potential of tissue iron, and only the more recent studies have focused on the toxic properties of circulating iron. Considering the fact that an increased saturation of transferrin and high iron in plasma are the hallmark of all hemochromatosis forms, an alternative view would be that toxic iron in the circulation is involved in the pathogenesis of hemochromatosis. Recent studies have shown an increased concentration of redox-active iron in plasma in patients with increased transferrin saturation. This finding supports the hypothesis that tissue iron may be the ‘smoking gun' of iron-induced organ damage. Taken together, caring for patients with suspected or established hemochromatosis still remains a challenge, where understanding the genetics, biochemistry and cell biology of hemochromatosis will aid better diagnosis and treatment of affected individuals.

Intracellular pH measurements of the whole head and the basal ganglia in chronic liver disease: A phosphorus-31 MR spectroscopy study

2000 ◽  
Vol 15 (3) ◽  
pp. 223-240 ◽  
Author(s):  
Nayna Patel ◽  
Daniel M. Forton ◽  
Glyn A. Coutts ◽  
Howard C. Thomas ◽  
Simon D. Taylor-Robinson
Keyword(s):  
Liver Disease ◽  
Basal Ganglia ◽  
Chronic Liver Disease ◽  
Intracellular Ph ◽  
Mr Spectroscopy ◽  
Chronic Liver ◽  
Spectroscopy Study ◽  
Ph Measurements

MR imaging of the basal ganglia in chronic liver disease: correlation of T1-weighted and magnetisation transfer contrast measurements with liver dysfunction and neuropsychiatric status

1995 ◽  
Vol 10 (2) ◽  
pp. 175-188 ◽  
Author(s):  
Simon D. Taylor-Robinson ◽  
Angela Oatridge ◽  
Joseph V. Hajnal ◽  
Andrew K. Burroughs ◽  
Neil McIntyre ◽  
...  
Keyword(s):  
Liver Disease ◽  
Basal Ganglia ◽  
Mr Imaging ◽  
Chronic Liver Disease ◽  
Liver Dysfunction ◽  
Chronic Liver ◽  
Magnetisation Transfer ◽  
Magnetisation Transfer Contrast

scholarly journals Diagnostic value of a superparamagnetic iron oxide in MR imaging of chronic liver disease in an animal model.

1998 ◽  
Vol 170 (3) ◽  
pp. 661-668 ◽  
Author(s):  
B Kreft ◽  
W Block ◽  
F Dombrowski ◽  
A Fackeldey ◽  
R Bachmann ◽  
...  
Keyword(s):  
Animal Model ◽  
Liver Disease ◽  
Iron Oxide ◽  
Mr Imaging ◽  
Chronic Liver Disease ◽  
Superparamagnetic Iron Oxide ◽  
Diagnostic Value ◽  
Chronic Liver

Nonhypervascular Hypointense Nodules at Gadoxetic Acid–enhanced MR Imaging in Chronic Liver Disease: Diffusion-weighted Imaging for Characterization

Radiology ◽  
2015 ◽  
Vol 277 (1) ◽  
pp. 309-309 ◽  
Author(s):  
Jiyoung Hwang ◽  
Young Kon Kim ◽  
Woo Kyoung Jeong ◽  
Dongil Choi ◽  
Hyunchul Rhim ◽  
...  
Keyword(s):  
Liver Disease ◽  
Mr Imaging ◽  
Chronic Liver Disease ◽  
Diffusion Weighted Imaging ◽  
Chronic Liver ◽  
Gadoxetic Acid ◽  
Diffusion Weighted ◽  
Disease Diffusion

Chronological evaluation of liver enhancement in patients with chronic liver disease at Gd-EOB-DTPA-enhanced 3-T MR imaging: does liver function correlate with enhancement?

2011 ◽  
Vol 30 (1) ◽  
pp. 25-33 ◽  
Author(s):  
Shinichi Nakamura ◽  
Kazuo Awai ◽  
Daisuke Utsunomiya ◽  
Tomohiro Namimoto ◽  
Takeshi Nakaura ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Function ◽  
Mr Imaging ◽  
Chronic Liver Disease ◽  
Chronic Liver
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