Advances in antiepileptic drug development

2011 ◽  
pp. 2-5
Author(s):  
Philip N Patsalos
Keyword(s):  
Drug Development ◽  
Antiepileptic Drug

Antiepileptic Drug Development in Children

Drugs ◽  
2008 ◽  
Vol 68 (1) ◽  
pp. 17-25 ◽  
Author(s):  
Catherine Chiron ◽  
Olivier Dulac ◽  
Gerard Pons
Keyword(s):  
Drug Development ◽  
Antiepileptic Drug

Antiepileptic Drug Development

2015 ◽  
pp. 61-74 ◽  
Author(s):  
Dieter Schmidt
Keyword(s):  
Drug Development ◽  
Antiepileptic Drug

Are neuronal nicotinic receptors a target for antiepileptic drug development? Studies in different seizure models in mice and rats

2003 ◽  
Vol 466 (1-2) ◽  
pp. 99-111 ◽  
Author(s):  
Wolfgang Löscher ◽  
Heidrun Potschka ◽  
Piotr Wlaź ◽  
Wojciech Danysz ◽  
Christopher G Parsons
Keyword(s):  
Drug Development ◽  
Antiepileptic Drug ◽  
Nicotinic Receptors ◽  
Development Studies ◽  
Neuronal Nicotinic Receptors ◽  
Seizure Models

scholarly journals Epileptogenesis, Ictogenesis and the Design of Future Antiepileptic Drugs

2003 ◽  
Vol 30 (1) ◽  
pp. 4-7 ◽  
Author(s):  
Donald F. Weaver
Keyword(s):  
Drug Design ◽  
Drug Development ◽  
Antiepileptic Drug ◽  
Antiepileptic Drugs ◽  
Paradigm Shift ◽  
Drug Of Choice ◽  
The Future ◽  
Conceptual Evolution

ABSTRACT:There is still no medical cure for epilepsy. Clinical epileptology is in need of a “paradigm shift” when it comes to the continuing development of therapeutics. An important first step in this conceptual evolution is differentiating between the notions of ictogenesis and epileptogenesis. All traditional therapeutics are anti-ictogenic, not antiepileptogenic. The future of antiepileptic drug development lies in the discovery of antiepileptogenics. Just as aspirin is not the drug of choice for meningitis, an anticonvulsant is not the drug of choice for epilepsy. Drug design for epilepsy needs to discover a penicillin, not more aspirins.

Mortality in antiepileptic drug development programs

Neurology ◽  
2001 ◽  
Vol 56 (4) ◽  
pp. 514-519 ◽  
Author(s):  
J. A. Racoosin ◽  
J. Feeney ◽  
G. Burkhart ◽  
G. Boehm
Keyword(s):  
Drug Development ◽  
Antiepileptic Drug ◽  
Development Programs
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