Youth high unemployment/unemployability in South Africa: the unemployed graduates' perspectives

PurposeThe purpose of this paper is to explore youth graduate unemployment and unemployability as a development problem in South Africa.Design/methodology/approachThis exploratory study applied a qualitative research method to elicit the perspectives of youth graduates regarding their unemployment and unemployability. A total of 30 face-to-face semi-structured interviews were conducted with unemployed youth who recently graduated from five South African universities.FindingsThe results indicate that, as youth graduate unemployment increases in South Africa, graduates become hopeless in terms of securing employment. The participants attributed their unemployment to multidimensional factors that include limited demand in the labour market, skills mismatch and lack of work experience.Research limitations/implicationsThis research exclusively focused on graduates from five South African universities; hence, the results of this small qualitative study cannot be generalised to the entire South African population. However, this paper offers important insights that may form the foundation for a nationwide study on a related topic.Originality/valueThis paper presents important insights that influence policy makers, government and other relevant stakeholders to develop alternative solutions to youth graduate unemployment. This paper recommends that government should play a critical role in bridging the gap between higher education and industry in order to address youth graduate unemployment. It also calls for a more cooperative effort between government, higher learning institutions and employers in order to create job opportunities for youth graduates in South Africa.

896 Fighting the war against COVID-19: administration of bamlanivimab (BAM) or bamlanivimab + etesivimab (BAM + E); a cooperative effort between a community cancer center and an urgent care (UC) facility

BackgroundGoal of the Massachusetts DPH is to ensure equitable distribution of BAM to the most vulnerable at risk of poor outcomes from COVID-19 and to communities with the highest incidences of COVID-19. Hospitals should allocate available doses in a manner consistent with this guidance:1. Patients who meet the EUA criteria; a lottery system will be used if supply is exceeded 2. Patients with comorbidities (high risk) tend to have worse outcomes when infected with SARS-CoV-2 3. BAM was approved under an EUA for the treatment of mild to moderate COVID-19 for those at high risk of progressing to severe disease (revoked 4/16/21). 4. BAM + E combo was approved under an EUA for the same patients and criteria, Southcoast Health entered into this relationship with DPH to provide this service to the southeastern MA population.MethodsPatients identified based on algorithm using Social Vulnerability Index (SVI) and EUA criteriaRNs screened cases for positive criteria using lottery priority and SVIPulmonologists consented appropriate patients, ordered infusions, routed cases for final scheduling within window of treatmentExperienced nursing staff from various Southcoast departments treated up to 6 patients per dayOncology pharmacies are uniquely experienced to prepare monoclonal antibodies (MABS) such as BAM and BAM + EDue to proximity of the Oncology pharmacy to the UC Center, pharmacy reviewed, prepared and delivered infusions to UC once patient was assessed by RNsResultsFirst 152 cases: 7.2% inpatient admissions within 14 days13.8% ED/UC visits within 14 days2% inpatient admissions in 28 days5.9% ED/UC visits within 28 daysTwo deaths during initial 152 cases.ConclusionsCooperative effort between the Cancer Center and Urgent Care led to positive outcomes for local COVID-19 patients. Southcoast demonstrated a 6% hospital admission rate for COVID-19 patients in the MAB program versus 26% admission rate overall for COVID-19 patients.AcknowledgementsThanks to our colleagues at the University of Rhode Island College of Pharmacy for their support with the poster

Theology without Anathemas

The object of the present essay is to establish the possibility of “theology without anathemas.” First, an argument is given for the conclusion that infallible knowledge in matters of theology is not now possible. Both the Protestant doctrine of claritas scripturae and the Roman Catholic understanding of the Magisterium of the Church are rejected. Then, an alternative, “fallibilist” ecclesiology is proposed, according to which (knowingly) to belong to the Church is a matter of (understanding oneself as) having been claimed by Christ as His own. When combined with a universal doctrine of election and a highly objective and actualized doctrine of the Atonement, such a conception of the Church makes it possible to understand theology as a collaborative and cooperative effort on the part of all to understand better this Christ to whom they all always already belong.

Digital Endpoints: Definition, Benefits, and Current Barriers in Accelerating Development and Adoption

The assessment of health and disease requires a set of criteria to define health status and progression. These health measures are referred to as “endpoints.” A “digital endpoint” is defined by its use of sensor-generated data often collected outside of a clinical setting such as in a patient’s free-living environment. Applicable sensors exist in an array of devices and can be applied in a diverse set of contexts. For example, a smartphone’s microphone might be used to diagnose or predict mild cognitive impairment due to Alzheimer’s disease or a wrist-worn activity monitor (such as those found in smartwatches) may be used to measure a drug’s effect on the nocturnal activity of patients with sickle cell disease. Digital endpoints are generating considerable excitement because they permit a more authentic assessment of the patient’s experience, reveal formerly untold realities of disease burden, and can cut drug discovery costs in half. However, before these benefits can be realized, effort must be applied not only to the technical creation of digital endpoints but also to the environment that allows for their development and application. The future of digital endpoints rests on meaningful interdisciplinary collaboration, sufficient evidence that digital endpoints can realize their promise, and the development of an ecosystem in which the vast quantities of data that digital endpoints generate can be analyzed. The fundamental nature of health care is changing. With coronavirus disease 2019 serving as a catalyst, there has been a rapid expansion of home care models, telehealth, and remote patient monitoring. The increasing adoption of these health-care innovations will expedite the requirement for a digital characterization of clinical status as current assessment tools often rely upon direct interaction with patients and thus are not fit for purpose to be administered remotely. With the ubiquity of relatively inexpensive sensors, digital endpoints are positioned to drive this consequential change. It is therefore not surprising that regulators, physicians, researchers, and consultants have each offered their assessment of these novel tools. However, as we further describe later, the broad adoption of digital endpoints will require a cooperative effort. In this article, we present an analysis of the current state of digital endpoints. We also attempt to unify the perspectives of the parties involved in the development and deployment of these tools. We conclude with an interdependent list of challenges that must be collaboratively addressed before these endpoints are widely adopted.

Technology Analysis and the Need of a Value Framework

The idea that technology is only a value-neutral instrument that can be used for good and bad purposes is not tenable anymore. Technology shapes our human life in all its dimensions and determines the direction of social changes. In the paper, I first show a few arguments in favor of the value-ladenness of technology and then approaches developed in response to that fact. I will argue that none of those responses is satisfactory, for they lack a formative value framework that would serve for decisions and their justification in the realm of technology development. Building such a framework requires a transdisciplinary and cooperative effort.

Trade in the Japanese Empire

Insecurity and inequality (both real and perceived) have defined the Japanese Empire as an entity of trade. If one the primary goals of Japan’s leaders during the Meiji period (1868–1912) was to revise the so-called unequal treaties, then having an empire was seen as a necessary means towards achieving this end. From the very beginning, strategic concerns proved inseperable from economic considerations. Imperial expansion into neighboring territories occurred simutaneously and worked hand in hand with forging an industrial nation-state. The empire began with the so-called internal colonization of Hokkaidō and then the Ryūkyū Islands (Okinawa), followed by Taiwan and Korea, spoils of victory after the Sino-Japanese and Russo-Japanese Wars, respectively. Taiwan and Korea represented Japan’s formal empire, and Japan developed these territories primarily as agricultural appendages—unequal and exclusive trading partners to provide foodstuffs for a growing, industrializing population in the home islands. As Japan developed its formal colonies toward a goal of agricultural self-sufficiency, it also pursued informal empire in China, which took shape as a competitive yet cooperative effort with other Western imperial powers under the treaty port system. World War I represented a turning point for imperial trade: At this time, Japan took advantage of a Europe preoccupied with internecine battles to ramp up the scope and scale of industrial production, which made Japan increasingly reliant on China—and particularly Manchuria—for raw materials necessary for heavy industry such as coal and iron. Japanese efforts to tighten its grip on China brought it into conflict with the Western imperialist powers and with a strengthening Chinese nation. Another major turning point was Japan’s 1931 takeover of Manchuria and the establishment of the puppet state of Manchukuo; these actions ended the treaty port system and sparked conflicts between China and Japan that broke out into full-out war by 1937. Although Japan was largely able to achieve agricultural self-sufficiency by the 1930s, it was unable to be fully self-reliant in essential resources for industry (and war) such as oil, tin, and iron. Resource self-sufficiency was a major goal for the construction of the Greater East Asia Co-Prosperity Sphere in the early 1940s. The Japanese Empire officially ended with defeat in 1945.

Personality and climate change mitigation: a psychological and semiotic exploration of the sustainable choices of optimists

Climate change is an anthropogenic existential threat that provokes extreme concern among climate scientists, but not, it seems, among all member of the public. Here, there is considerably more variability in level of concern and, it appears, in everyday sustainable behavior. But how does personality affect this variability in behavior? And how are underlying personality states like dispositional optimism linked to more sustainable everyday practices? Research in clinical psychology has suggested that dispositional optimism is a very positive personality characteristic associated with higher levels of hope and resilience, but applied research from other domains has reported that optimists can, on occasion, bury their heads in the sand and avoid attending to external threats, like climate change, in order to maintain mood state. So are optimists more immune to climate change messaging than non-optimists? And do they make fewer sustainable choices? A series of experimental studies, manipulating signifiers of carbon footprint (Study 1) and eco labels on products (Study 2) found that optimists made more sustainable choices than non-optimists and that both groups were influenced equally by climate change film clips in terms of sustainable choices (Study 1). Optimists also displayed a false consensus effect, overestimating the proportion of people who would behave more sustainably like themselves (Study 3). Given that global problems like climate change need concerted, cooperative effort, these optimistic beliefs about how others behave could be adaptive in the long-run. Designing climate change messages to appeal to optimists might be a critical consideration for the future.

Study assessing the efficacy of herbal teas on bone health and quality of life in a population with osteopenia: rooibos actions on melatonin and tulsi actions on quality of life.

The purpose of the OsTea translational study was to assess the efficacy of teas (tulsi, rooibos, oolong) compared to placebo (coriander) on markers of bone health and quality of life (QOL) in those with osteopenia and on human mesenchymal stem cell (hMSC) differentiation into osteoblasts to identify potential mechanisms of action. Following consumption of tea (3 times/day; 90 days), participants collected a urine sample during the night (10pm-6am) and filled in questionnaires before and after the study. Rooibos consumption demonstrated a significant decrease in urinary CTX levels vs placebo; trended towards increases in nocturnal melatonin levels (p=0.06); significantly decreased serotonin-producing microbes in the gut; and demonstrated trends towards improvements (p=0.09) in QUALIOST emotional parameters. Tulsi consumption primarily affected subjective measures, such as significantly improved scores for PSS, STAI-trait anxiety, and osteoporosis/osteopenia-related parameters in the QUALIOST. To further identify potential mechanisms underlying these actions of rooibos on CTX and melatonin (urinary and gut), rooibos and melatonin effects on human osteoblastogenesis were carried out for 21 days under oxidative stress conditions to mimic osteopenia. Although both rooibos and melatonin protected against oxidative stress-induced loss of osteoblasts in vitro, their underlying mechanisms were different. Melatonin, like tulsi and oolong, demonstrated the greatest protection against oxidative stress at days 10-11 of exposure, which was due to effects on hMSC viability and through melatonin receptors. Rooibos, on the other hand, demonstrated protection at days 10-11 and 20-21, which was through signaling mechanisms involved in differentiation processes and not on cell viability. These findings suggest that the clinical actions of rooibos on decreasing CTX levels in a population with osteopenia may be through a cooperative effort between melatonin and rooibos by protecting hMSC viability against oxidative stress-induced loss and by promoting osteoblast differentiation, respectively. This study also supports the use of tulsi for improving quality of life in a population susceptible to osteoporosis.

Clinical exome sequencing is a powerful tool in the diagnostic flow of monogenic kidney diseases: an Italian experience

Background A considerable minority of patients on waiting lists for kidney transplantation either have no diagnosis (and fall into the subset of undiagnosed cases) because kidney biopsy was not performed or histological findings were non-specific, or do not fall into any well-defined clinical category. Some of these patients might be affected by a previously unrecognised monogenic disease. Methods Through a multidisciplinary cooperative effort, we built an analytical pipeline to identify patients with chronic kidney disease (CKD) with a clinical suspicion of a monogenic condition or without a well-defined diagnosis. Following the stringent phenotypical and clinical characterization required by the flowchart, candidates meeting these criteria were further investigated by clinical exome sequencing followed by in silico analysis of 225 kidney-disease-related genes. Results By using an ad hoc web-based platform, we enrolled 160 patients from 13 different Nephrology and Genetics Units located across the Piedmont region over 15 months. A preliminary “remote” evaluation based on well-defined inclusion criteria allowed us to define eligibility for NGS analysis. Among the 138 recruited patients, 52 (37.7%) were children and 86 (62.3%) were adults. Up to 48% of them had a positive family history for kidney disease. Overall, applying this workflow led to the identification of genetic variants potentially explaining the phenotype in 78 (56.5%) cases. Conclusions These results underline the importance of clinical exome sequencing as a versatile and highly useful, non-invasive tool for genetic diagnosis of kidney diseases. Identifying patients who can benefit from targeted therapies, and improving the management of organ transplantation are further expected applications.