Personalized multitarget biologic injection in the spine: prospective case series of multitarget platelet-rich plasma for low back pain

2021 ◽  
Author(s):  
Edilson S Machado ◽  
Mary A Ambach ◽  
José MP Caldas ◽  
Jason J Wei ◽  
Markus Bredemeier

Aim: To evaluate the use of a multitarget platelet-rich plasma (PRP) injection approach for the treatment of chronic low back pain (LBP). Materials & Methods: Forty-six patients with more than 12 weeks of LBP who failed conservative treatments were injected with PRP into the facet joints, intervertebral discs, epidural space and/or paravertebral muscles. Visual analog pain scale and Roland-Morris Disability Questionnaire scores were measured at baseline and predefined intervals. Results: Mean visual analog pain scale was reduced from 8.48 to 5.17 and mean Roland-Morris Disability Questionnaire from 18.0 to 10.98 at 12 weeks (p < 0.001). These statistically significant improvements were sustained over 52 weeks. No adverse effects were observed. Conclusion: Our PRP approach demonstrated clinically favorable results and may be a promising treatment for chronic LBP.

Spine ◽  
2001 ◽  
Vol 26 (24) ◽  
pp. 2738-2743 ◽  
Author(s):  
Ayse A. Küçükdeveci ◽  
Alan Tennant ◽  
Atilla H. Elhan ◽  
Hava Niyazoglu

2020 ◽  
Vol 19 (4) ◽  
pp. 277-281
Author(s):  
HELOISA FLORENTINO DRUMMOND ◽  
THIAGO SAIKALI FARCIC ◽  
NELSON CARVAS JUNIOR ◽  
CRISTIANO SCHIAVINATO BALDAN ◽  
IGOR FAGIOLI BORDELLO MASSON ◽  
...  

ABSTRACT Objective To correlate chronic low back pain with female sexual function. Methods This is a cross-sectional study. Thirty-two women aged between 18 and 44 years old, with body mass index (BMI) between 18.5 kg/m2 and 29.9 kg/m2, with a medical diagnosis of chronic low back pain and sexually active in the last six months were selected. The patients underwent a physical therapy evaluation and responded to two questionnaires: the Roland-Morris Disability Questionnaire and the Female Sexual Quotient (QS-F). Pearson’s correlation test was used to assess the impact of chronic low back pain on sexual activity. Results The mean age was 30.31 years old (±.7.10) and the mean BMI was 24.54 Kg/m2 (±3.06). The mean Roland-Morris Disability Questionnaire score was 5.2 ( ± 3.28), indicating that the patients did not have significant disability. The mean QS-F score was 60.37 (±14.48), classified as “unfavorable to normal”. The correlation test showed a low correlation between chronic low back pain and female sexual function (r = 0.027). Conclusion There was a low correlation between chronic low back pain and female sexual function in the study population, but the moderate correlation between the “comfort” domain and the Roland-Morris Disability Questionnaire score was significant. Level of evidence II ; Cross-sectional clinical study.


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