Cervical Intramedullary Spinal Cord Glioblastoma in a 10 Year-Old Child. Case Report

Among all pediatric tumors in CNS, the intramedullary spinal cord tumors are less than one-third of 1% and only about 1-3% of them are high-grade gliomas. Intramedullary glioblastoma (GBM) is considered highly threatening because of its aggressiveness and, even with intense management, lesion progress and patients develop severe deficits. Authors report a very rare case of a 10-year-old patient with extensive cervical GBM with an unusual outcome.

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Intramedullary spinal cord metastases of malignant melanoma: A rare case report on paraplegia in palliative care

Indian Journal of Palliative Care ◽

10.4103/ijpc.ijpc_163_18 ◽

2019 ◽

Vol 25 (3) ◽

pp. 468

Author(s):

Arunangshu Ghoshal ◽

Rutula Sonawane ◽

Anuja Damani ◽

MaryAnn Muckaden ◽

JayitaK Deodhar

Keyword(s):

Spinal Cord ◽

Palliative Care ◽

Case Report ◽

Malignant Melanoma ◽

Rare Case ◽

Intramedullary Spinal Cord ◽

Rare Case Report

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Pediatric spinal cord diffuse midline glioma, H3 K27-altered with intracranial and spinal leptomeningeal spread: A case report

The Neuroradiology Journal ◽

10.1177/19714009211067402 ◽

2022 ◽

pp. 197140092110674

Author(s):

Bettina L Serrallach ◽

Brandon H Tran ◽

David F Bauer ◽

Carrie A Mohila ◽

Adekunle M Adesina ◽

...

Keyword(s):

Spinal Cord ◽

Case Report ◽

Female Adolescent ◽

Rapid Progression ◽

Imaging Features ◽

High Grade ◽

Who Grade ◽

Leptomeningeal Seeding ◽

High Grade Gliomas ◽

Diffuse Midline Glioma

Primary spinal cord high-grade gliomas, including those histologically identified as glioblastoma (GBM), are a rare entity in the pediatric population but should be considered in the differential diagnosis of intramedullary lesions. Pediatric spinal cord high-grade gliomas have an aggressive course with poor prognosis. The aim of this case report is to present a 15-year-old female adolescent with histopathologically confirmed spinal cord GBM with H3F3A K27 M mutation consistent with a diffuse midline glioma (DMG), H3 K27-altered, CNS WHO grade 4 with leptomeningeal seeding on initial presentation. As imaging features of H3 K27-altered DMGs are non-specific and may mimic more frequently encountered neoplastic diseases as well as demyelinating disorders, severe neurological deficits at presentation with short duration, rapid progression, and early leptomeningeal seeding should however raise the suspicion for a pediatric-type diffuse high-grade glioma like DMG, H3 K27-altered.

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Concurrent intramedullary spinal cord and multiple intracranial tuberculomas with tuberculous optic neuritis: A rare case report

Indian Journal of Tuberculosis ◽

10.1016/j.ijtb.2016.10.007 ◽

2017 ◽

Vol 64 (4) ◽

pp. 337-340

Author(s):

Lulup Sahoo ◽

Ashok Kumar Mallick ◽

Geeta Mohanty ◽

Kali Prasanna Swain ◽

Soumyadarshan Nayak ◽

...

Keyword(s):

Spinal Cord ◽

Case Report ◽

Optic Neuritis ◽

Rare Case ◽

Intramedullary Spinal Cord ◽

Rare Case Report

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Intramedullary Spinal Cord Ganglioglioma Presenting as Hyperhidrosis: A Rare Case Report and Literature Review

World Neurosurgery ◽

10.1016/j.wneu.2019.03.115 ◽

2019 ◽

Vol 127 ◽

pp. 232-236

Author(s):

Wei Shi ◽

Benqi Zhao ◽

Jingjing Yao ◽

Yang Zhou ◽

Mengqi Tong ◽

...

Keyword(s):

Spinal Cord ◽

Case Report ◽

Literature Review ◽

Rare Case ◽

Intramedullary Spinal Cord ◽

Rare Case Report

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The Association of Hydrocephalus with Intramedullary Spinal Cord Tumors: A Series of 25 Patients

Neurosurgery ◽

10.1227/00006123-199011000-00012 ◽

1990 ◽

Vol 27 (5) ◽

pp. 749-754 ◽

Cited By ~ 77

Author(s):

Stephanie Rifkinson-Mann ◽

Jeffrey H. Wisoff ◽

Fred Epstein

Keyword(s):

Spinal Cord ◽

Malignant Tumors ◽

Spinal Cord Tumor ◽

Benign Tumors ◽

High Grade ◽

Spinal Cord Tumors ◽

Increased Intracranial Pressure ◽

Intramedullary Spinal Cord ◽

Spinal Cysts ◽

The Relationship

Abstract 171 patients with intramedullary spinal cord tumors were operated on, of which 25 patients (15%), mostly children, developed symptomatic hydrocephalus. Twenty patients (12%) had malignant tumors, with 13 of the 20 cases (63%) complicated by increased intracranial pressure and ventriculomegaly. Of the remaining 151 patients with benign tumors (89%), only 12 (8%) developed symptomatic hydrocephalus. In an effort to understand the relationship between hydrocephalus and intramedullary spinal cord tumor, the authors analyze the level and histology of the neoplasm, as well as its association with spinal cysts. A review of the neurosurgical literature reveals that 34 similar cases of hydrocephalus associated with intramedullary spinal cord tumors have been reported to date. The authors note that the presence of hydrocephalus in patients with malignant intramedullary astrocytomas is associated with a shorter rate of survival than in those patients with high-grade lesions but without hydrocephalus, apparently due to rapid tumor progression. The ventriculomegaly seen with benign spinal cord gliomas has no statistically significant effect upon longterm prognosis.

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