Pediatric spinal cord diffuse midline glioma, H3 K27-altered with intracranial and spinal leptomeningeal spread: A case report

Primary spinal cord high-grade gliomas, including those histologically identified as glioblastoma (GBM), are a rare entity in the pediatric population but should be considered in the differential diagnosis of intramedullary lesions. Pediatric spinal cord high-grade gliomas have an aggressive course with poor prognosis. The aim of this case report is to present a 15-year-old female adolescent with histopathologically confirmed spinal cord GBM with H3F3A K27 M mutation consistent with a diffuse midline glioma (DMG), H3 K27-altered, CNS WHO grade 4 with leptomeningeal seeding on initial presentation. As imaging features of H3 K27-altered DMGs are non-specific and may mimic more frequently encountered neoplastic diseases as well as demyelinating disorders, severe neurological deficits at presentation with short duration, rapid progression, and early leptomeningeal seeding should however raise the suspicion for a pediatric-type diffuse high-grade glioma like DMG, H3 K27-altered.

The Effect of Age, Biological Maturation and Birth Quartile in the Kinanthropometric and Physical Fitness Differences between Male and Female Adolescent Volleyball Players

Background: Differences in kinanthropometric and physical fitness performance between boys and girls usually start during adolescence, as a result of the changes in the hormonal environment that occur with the advance of age and biological maturation; Methods: A total of 96 1st Regional Division players adolescent volleyball players, 48 males, (age = 14.17 ± 1.00 years-old) and 48 females (age = 14.41 ± 1.21 years-old) underwent a kinanthropometric assessment, were asked to perform different physical fitness test and to complete a questionnaire. Chronological age, maturity offset, age at peak height velocity (APHV), and birth quartile were calculated; Results: Statistical differences were observed between male and female players in the APHV (p < 0.001). Male players showed higher values in the bone and muscle-related variables (p < 0.001–0.040), as well as in the strength and power production-related physical tests (p < 0.001–0.012), while the female showed higher values in the fat-related variables (p = 0.003–0.013), and performed better in the flexibility tests. Age, maturity offset, and birth quartile showed to have statistical influence in the differences found between sex groups; Conclusions: There is a clear influence of age and biological maturation on the differences found between sexes in adolescent volleyball players that could be taken into account regarding grouping in early stages.

Prediction of Resilience Based on Personality Traits of Female Adolescent Students

In high school students’ anxiety is very common problem for all. Nevertheless, the students predict to be stressful increasing with several sources of stress especially with Academic stress. How to respond to stress and challenges affect the entire life of them. The current study tries to investigate the relationship between resilience and personality traits. Moreover, the other important objective is to examine whether big five personality traits predict resilience of high school female students or not. Till now, very limited studies have been conducted in India in context to high school female students. Enrolled in academic session 2020-21, 85 students studying Humanities in 12th standard, in GGSSS, Delhi, India were selected to participate in the study. The standardized questionnaires of the Ego Resilience Scale and Big Five Personality Test were used as the tool of the study. The data was collected using both the questionnaires and interpreted using Pearson correlation and multiple linear regression at a significance level p<0.05. As a result of analysis, Pearson Correlation shows that all the personality traits E, A, C, O have a significant positive correlation with Resilience (r= .539, r=.734, r=.792 and r=. 751 respectively) but N has a significant negative correlation with resilience (r=-.684). Furthermore, the results reveal a statistically significant relationship between the variables of Conscientiousness, Neuroticism, and Agreeableness, and the participants’ resilience scores (R=.859, R2= .738, p<.05). These three personality traits together account for 73% of the total variance in resilience (F=75.94, p<.05). It is concluded that Understanding of the levels and relationship among Personalities and Resilience of adolescents can assist in predicting the performance level of the students and in future intervention programs can be developed accordingly for the students for a successful and satisfactory life.

The Trends and Experiences of Sexual and Reproductive Health among Late Female Adolescents in Bangladesh

Adolescence period is a very important transitional stage of human develoment as in this period a human being undergoes some major physical, emotional and social changes. Bangladesh has an adolescent population consisting one fifth of the total population. Among them almost half of them are girls. Among the adolescent girls who belong to the late adolescent age group are in the most exposed and disadvantaged situation in the context of Sexual and Reproductive Health (SRH) of Bangladesh. Therefore, the aim of this article is to concentrate on the SRH of adlescents girls (15-19 years) with an aim to reveal the trends and experieces of SRH among this group and some major challenges so that female adolescent SRH issues can receive proper attention in the policy making level.

Stiff Person Syndrome and Encephalitis with GAD Antibodies with Severe Anterograde Amnesia in an Adolescent: A Case Study and Literature Review

Antiglutamic acid decarboxylase (GAD65) encephalitis is rare and few pediatric cases have been reported, with variable clinical presentations. A 14-year-old female adolescent was managed in our department. She had been treated for several months for drug-resistant temporal lobe epilepsy and gradually presented major anterograde amnesia with confusion. Upon her arrival at the University Hospital Centre, she showed a classical form of stiff person syndrome. The brain magnetic resonance imaging showed bitemporal hyperintensities and hypertrophy of the amygdala. The blood and cerebrospinal fluid were positive for GAD65 antibodies. At 2 years of immunosuppressive treatment and rehabilitation, the course showed partial improvement of the memory and neuropsychiatric impairment, and epilepsy that continued to be active. GAD65 antibodies are associated with various neurological syndromes, and this presentation combining limbic encephalitis and stiff person syndrome is the first pediatric form published to date; there are also few cases described in adults.

The Effect of Flipped Classroom on Iranian Adolescents: Elementary EFL Learners’ Vocabulary Recall and Retention

Vocabulary as an inseparable part of language learning has a vital role in communication, which requires to be taught in new approaches. A quasi-experimental method was used to achieve the aims of the current study. In doing this, 48 Iranian female adolescent elementary learners (13–17) were assigned based on the Oxford Quick Placement Test from 70 female students to take part in 4 sessions of treatment. The participants were randomly divided into two groups: an experimental group (n = 24) and a control group (n = 24). The experimental group was taught using the flipped classroom, while the control group was exposed to the conventional methods. Research instruments involving an English language placement test, vocabulary pretest, immediate posttest, and delayed test (the study lasted for 9 weeks). A list of 28 target words was given to both groups. Words were selected by the Lawshe content validity ratio (CVR) and content validity index (CVI) to have validity. The findings of ANCOVA indicated that conducting the flipped classrooms has significant impacts on Iranian adolescent elementary students’ vocabulary recall and retention. Hence, it is an applicable approach that carries important implications for teachers, foreign language syllabus designers, and curriculum planners.