This chapter presents a higher-order-logic formalization of the main concepts of information theory (Cover & Thomas, 1991), such as the Shannon entropy and mutual information, using the formalization of the foundational theories of measure, Lebesgue integration, and probability. The main results of the chapter include the formalizations of the Radon-Nikodym derivative and the Kullback-Leibler (KL) divergence (Coble, 2010). The latter provides a unified framework based on which most of the commonly used measures of information can be defined. The chapter then provides the general definitions that are valid for both discrete and continuous cases and then proves the corresponding reduced expressions where the measures considered are absolutely continuous over finite spaces.