scholarly journals Benzylation of N-phenyl-2-phenylacetamide under microwave irradiation

2008 ◽  
Vol 73 (10) ◽  
pp. 945-950 ◽  
Author(s):  
Dusan Mijin ◽  
Masa Prascevic ◽  
Slobodan Petrovic
Keyword(s):  
Gas Chromatography ◽  
Microwave Irradiation ◽  
Potassium Hydroxide ◽  
Benzyl Chloride ◽  
Main Product ◽  
Phase Transfer ◽  
Solvent Free ◽  
Free System ◽  
Phase Transfer Catalysts ◽  
Solvent Free System

N-Phenyl-2-phenylacetamide was alkylated with benzyl chloride in the presence of powdered potassium hydroxide under microwave irradiation in a solvent-free system. The reactions were also performed in the presence of phase-transfer catalysts. The formation of N-, O- and C-products of alkylation was followed by gas chromatography. The N-product was found to be the main product under microwave irradiation. The O-product was obtained in higher yields when an excess of base and benzyl chloride was used.

scholarly journals Alkylation of N-substituted 2-phenylacetamides: Benzylation of N-(4-chlorophenyl)-2-phenylacetamide

2004 ◽  
Vol 69 (2) ◽  
pp. 85-92 ◽  
Author(s):  
Dusan Mijin ◽  
Vida Jankovic ◽  
Slobodan Petrovic
Keyword(s):  
Gas Chromatography ◽  
Potassium Hydroxide ◽  
Benzyl Chloride ◽  
Phase Transfer ◽  
Alkylation Reaction ◽  
Reaction Products ◽  
Reaction Conditions ◽  
Phase Transfer Catalysts ◽  
Different Temperatures

Benzylation of N-(4-chlorophenyl)-2-phenylacetamidewith benzyl chloride in the presence of powdered potassium hydroxide under various reaction conditions was performed in order to establish the possible reaction products. Different temperatures and ratios of reactants and solvents were used. The reactions were also carried out in the presence of different phase-transfer catalysts in toluene as a solvent. The formation of the reaction products was followed using gas chromatography. On the basis of the obtained results, the reactivity and the orientation in the alkylation reaction of the investigated amide is discussed.

Synthesis of Fatty Acetoacetates Under Microwave Irradiation Catalysed by Sulfamic Acid in a Solvent-Free System

2016 ◽  
Vol 93 (10) ◽  
pp. 1399-1406 ◽  
Author(s):  
Andressa C. H. Weber ◽  
Thaís C. Batista ◽  
Bruno Gonçalves ◽  
Carolina R. L. Hack ◽  
Larissa M. Porciuncula ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Sulfamic Acid ◽  
Solvent Free ◽  
Free System ◽  
Solvent Free System

scholarly journals Alkylation of N-substituted 2-phenylacetamides: Benzylation of N-(4-nitrophenyl)-2-phenylacetamide

2002 ◽  
Vol 67 (6) ◽  
pp. 373-379 ◽  
Author(s):  
Vida Jankovic ◽  
Dusan Mijin ◽  
Slobodan Petrovic
Keyword(s):  
Potassium Hydroxide ◽  
Benzyl Chloride ◽  
Phase Transfer ◽  
Product Formation ◽  
Phase Transfer Catalysts ◽  
Different Temperatures

N-(4-Nitrophenyl)-2-phenylacetamide was alkylated with benzyl chloride in the presence of powdered potassium hydroxide at different temperatures and in various solvents in order to establish the reactivity and orientation in the reaction. The reactions were also carried out in the presence of different phase-transfer catalysts in toluene. Product formation was followed by GC. The obtained results were compared to the results of the benzylation of other N-substituted 2-phenylacetamides, especially of N-phenyl-2-phenylacetamide.

From glycerol to chlorohydrin esters using a solvent-free system. Microwave irradiation versus conventional heating

Tetrahedron ◽  
2009 ◽  
Vol 65 (50) ◽  
pp. 10370-10376 ◽  
Author(s):  
Marc Escribà ◽  
Jordi Eras ◽  
Miquel Duran ◽  
Sílvia Simon ◽  
Cristina Butchosa ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Solvent Free ◽  
Conventional Heating ◽  
Free System ◽  
Solvent Free System
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