A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus

Diabetes ◽  
1984 ◽  
Vol 33 (2) ◽  
pp. 176-183 ◽  
Author(s):  
G. I. Bell ◽  
S. Horita ◽  
J. H. Karam
Keyword(s):  
Diabetes Mellitus ◽  
Human Insulin ◽  
Polymorphic Locus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Gene ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Human Insulin Gene ◽  
Insulin Dependent

A genetic marker for non-insulin-dependent diabetes and atherosclerosis

1983 ◽  
Vol 104 (4_Suppl) ◽  
pp. S43-S46
Author(s):  
D. Owerbach ◽  
K. Johansen ◽  
P. Billesbølle ◽  
S. Poulsen ◽  
M. Schroll ◽  
...  
Keyword(s):  
Genetic Marker ◽  
Human Insulin ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Gene ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Chromosome 11 ◽  
Human Insulin Gene ◽  
Dna Restriction Fragments ◽  
Insulin Dependent

ABSTRACT. The human insulin gene has been localized to the short arm of chromosome 11. The length of a segment of DNA associated with the human insulin gene is polymorphic. In patients with non-insulin-dependent diabetes mellitus (NIDDM) the proportion of subjects homozygous for DNA restriction fragments of a large size class (U alleles) in the polymorphic region was significantly higher than in normal controls. The U allele is thus associated with at least one type of NIDDM. The U-alleles were also strongly associated with macroangiopathy in diabetic as well as in non-diabetic subjects. Key words: DNA polymorphism, chromosome 11, genetic marker, human insulin gene, non-insulin-dependent diabetes, glucose regulation, atherosclerosis, macroangiopathy.

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