The role of histocompatibility antigens in transplantation of isolated islets of Langerhans in the rat

Diabetes ◽  
1993 ◽  
Vol 42 (1) ◽  
pp. 90-97 ◽  
Author(s):  
W. F. Hiller ◽  
B. Steiniger ◽  
J. Klempnauer
1978 ◽  
Vol 76 (3) ◽  
pp. 479-486 ◽  
Author(s):  
J. P. ASHBY ◽  
D. SHIRLING ◽  
J. D. BAIRD

Implants of progesterone resulted in an increased amount of insulin in plasma in response to intravenous administration of glucose in the rat. Isolated islets of Langerhans from progesterone-treated animals showed a greater maximum secretory response to glucose than islets from control animals but their sensitivity to low concentrations of glucose was unchanged. Theophylline increased glucose-induced secretion of insulin to a greater extent in progesterone-treated than in control rats and also produced a greater increase in the concentration of cyclic AMP in isolated islets from hormone-treated animals. These results suggest that the effect of progesterone on insulin secretion may be mediated by a change in cyclic AMP levels in the β cell. The possible role of progesterone in increasing the secretion of insulin in pregnancy is discussed.


1973 ◽  
Vol 29 (7) ◽  
pp. 881-882 ◽  
Author(s):  
Brigitte Ziegler ◽  
R. Butter ◽  
H. -J. Hahn ◽  
R. Mehling ◽  
H. Fiedler

Diabetes ◽  
1969 ◽  
Vol 18 (6) ◽  
pp. 381-386 ◽  
Author(s):  
K. D. Buchanan ◽  
J. E. Vance ◽  
R. H. Williams

1975 ◽  
Vol 6 (3) ◽  
pp. 169-176 ◽  
Author(s):  
H.J. Hahn ◽  
H. Jahr ◽  
K.D. Kohnert ◽  
H. Zühlke

Diabetologia ◽  
1980 ◽  
Vol 18 (3) ◽  
pp. 229-232 ◽  
Author(s):  
T. Ghafghazi ◽  
M. L. McDaniel ◽  
P. E. Lacy

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