Cell therapy and left ventricular restoration for ischemic cardiomyopathy: long-term results of a perspective, randomized study

2019 ◽  
Vol 67 (1) ◽  
Author(s):  
Guglielmo Stefanelli ◽  
Fabrizio Pirro ◽  
Alina Olaru ◽  
Paolo Giovanardi ◽  
Marco Meli ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Ischemic Cardiomyopathy ◽  
Randomized Study ◽  
Left Ventricular ◽  
Long Term Results ◽  
Left Ventricular Restoration ◽  
Ventricular Restoration

Abstract 2262: No Impact Of The Mitral Annuloplasty On Overall Survival In Patients With Ischemic Cardiomyopathy - Long-term Follow-up Study.

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Krzysztof S Golba ◽  
Jolanta Biernat ◽  
Marek A Deja ◽  
Wojciech Domaradzki ◽  
Marek Jasiński ◽  
...  
Keyword(s):  
Overall Survival ◽  
Mitral Regurgitation ◽  
Ischemic Cardiomyopathy ◽  
Cox Regression ◽  
Coronary Bypass ◽  
Left Ventricular ◽  
Long Term Results ◽  
Mitral Annuloplasty ◽  
Cox Regression Analysis

Good long-term results are reported after the mitral valve (MV) repair for ischemic regurgitation. The aim of the study was to identify predictors of the overall survival after routine MV repair in patients with ischemic cardiomyopathy. Methods. 164 patients, 60.9±8.66 years old, with chronic ischemic mitral regurgitation and left ventricle ejection fraction (EF) = 30.7±6.04 undergoing coronary bypass with or without MV repair were prospectively followed for 5.1±1.63 years. A Cox proportional hazards model evaluated overall survival as a function of baseline age, sex, EF, mitral regurgitation jet area, left atrial area, atrial fibrillation, NYHA class, prior anterior or inferior myocardial infarction, medical comorbidities, MV repair, left ventricular plasty, left main and 3 vessel disease, venous graft to left anterior descending artery, number of grafts and year of operation. Treatment selection bias was controlled by deriving a propensity score for mitral annuloplasty. Results. Predictors included in the Cox regression model of overall survival are presented in table . The ROC curve analysis revealed EF <30.0, (sensitivity and specificity - 61.7% and 59.0%, respectively) and serum creatinine >1.17, (45.6% and 77.2%) as a cut-off values in the prediction of overall survival. Conclusions. There is no impact of the mitral annuloplasty on overall survival in these patients. MV repair can be safely added to coronary bypass grafting in patients with ischemic cardiomyopathy. Multivariable Cox regression analysis results

scholarly journals Long-Term Results of Hybrid Left Ventricular Reconstruction in the Treatment of Ischemic Cardiomyopathy

2021 ◽  
Author(s):  
Jan Naar ◽  
Ivo Skalský ◽  
Andreas Krűger ◽  
Filip Málek ◽  
Kevin Van Bladel ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ischemic Cardiomyopathy ◽  
Left Ventricular ◽  
Ischemic Heart ◽  
Volume Index ◽  
Long Term Results ◽  
Ischemic Heart Failure ◽  
Left Ventricular Reconstruction ◽  
Anchoring System

AbstractThe evidence supporting surgical aneurysmectomy in ischemic heart failure is inconsistent. The aim of the study was to describe long-term effect of minimally invasive hybrid transcatheter and minithoracotomy left ventricular (LV) reconstruction in patients with ischemic cardiomyopathy. Twenty-three subjects with transmural anterior wall scarring, LV ejection fraction 15–45%, and New York Heart Association class ≥ II were intervened using Revivent TC anchoring system. LV end-systolic volume index was reduced from 73.2 ± 27 ml at baseline to 51.5 ± 22 ml after 6 months (p < 0.001), 49.9 ± 20 ml after 2 years (p < 0.001), and 56.1 ± 16 ml after 5 years (p = 0.047). NYHA class improved significantly at 5 years compared to baseline. Six-min walk test distance increased at 2 years compared to the 6-month visit. Hybrid LV reconstruction using the anchoring system provides significant and durable LV volume reduction during 5-year follow-up in preselected patients with ischemic heart failure. Graphical abstract

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