Ischemic Cardiomyopathy
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2021 ◽  
Author(s):  
Vladimir V. Shipulin ◽  
Sergey L. Andreev ◽  
Andrew S. Pryakhin ◽  
Andrew V. Mochula ◽  
Alina N. Maltceva ◽  
...  

Abstract Purpose: The purpose of present study was to assess the feasibility of GBPS with low-dose dobutamine (LDD) stress test, performed on a SPECT camera equipped with Cadmium-Zinc-Telluride (CZT) solid state detectors in evaluation of patients with ischemic heart failure (HF).Methods. A total of 52 patients with ischemic cardiomyopathy (ICM) and a control group of 10 patients without obstructive coronary artery lesion underwent GBPS and transthoracic echocardiography (TTE) at rest and during LDD stress test (5, 10, 15 µg/kg/min). The duration of each GBPS step was 5 minutes. Stress-induced changes (∆) in LV ejection fraction (LVEF), peak ejection rate, LV volumes and dyssynchrony (phase histogram standard deviation, phase histogram bandwidth and entropy) obtained with GBPS were estimated. Results. All GBPS indices except end-diastolic volume showed significant dynamics during stress test in both groups. 17% of ICM patients, but none from control group, showed a decrease in EF during stress, accompanied by a significant increase in entropy. The inter-rater reproducibility was excellent for both rest and stress studies. There was a moderate correlation (r=0.5, p=0.01) between GBPS and TTE, with a mean difference value of -1.7 (95% confidence interval -9.8; 6.4; p=0.06) in ΔLVEF. Conclusion. Low-dose dobutamine stress gated blood pool SPECT performed with high-efficiency CZT-SPECT cameras allow evaluation of stress-induced changes in LV contractility and dyssynchrony in patients with ischemic HF. The high sensitivity of the semiconductor detectors provides an opportunity to perform GBPS with lower acquisition time and a decrease in patient radiation exposure. ClinicalTrials.gov identifier: NCT04508608 (August 7, 2020)


Author(s):  
Antonio Calafiore ◽  
Antonio Totaro ◽  
Sotirios Prapas ◽  
Kostas katsavrias ◽  
Stefano Guarracini ◽  
...  

Resection or exclusion of scars following a myocardial infarction on the LAD territory started even before the beginning of the modern era of cardiac surgery. Many techniques were developed, but there is still confusion on who did what. The original techniques underwent modifications that brought to a variety of apparently new procedures that, however, were only a “revisitation” of what described before. In some case old techniques were reproposed and renamed, without giving credit to the surgeon that was the original designer. Herein we try to describe which are the seminal procedures and some of the most important modifications, respecting however the merit of who first communicated the procedure to the scientific world.


CHEST Journal ◽  
2021 ◽  
Vol 160 (4) ◽  
pp. A87
Author(s):  
Malik Ghawanmeh

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Susana Merino-Caviedes ◽  
Lilian K. Gutierrez ◽  
José Manuel Alfonso-Almazán ◽  
Santiago Sanz-Estébanez ◽  
Lucilio Cordero-Grande ◽  
...  

AbstractDelayed gadolinium-enhanced cardiac magnetic resonance (LGE-CMR) imaging requires novel and time-efficient approaches to characterize the myocardial substrate associated with ventricular arrhythmia in patients with ischemic cardiomyopathy. Using a translational approach in pigs and patients with established myocardial infarction, we tested and validated a novel 3D methodology to assess ventricular scar using custom transmural criteria and a semiautomatic approach to obtain transmural scar maps in ventricular models reconstructed from both 3D-acquired and 3D-upsampled-2D-acquired LGE-CMR images. The results showed that 3D-upsampled models from 2D LGE-CMR images provided a time-efficient alternative to 3D-acquired sequences to assess the myocardial substrate associated with ischemic cardiomyopathy. Scar assessment from 2D-LGE-CMR sequences using 3D-upsampled models was superior to conventional 2D assessment to identify scar sizes associated with the cycle length of spontaneous ventricular tachycardia episodes and long-term ventricular tachycardia recurrences after catheter ablation. This novel methodology may represent an efficient approach in clinical practice after manual or automatic segmentation of myocardial borders in a small number of conventional 2D LGE-CMR slices and automatic scar detection.


Author(s):  
srilakshmi adhyapak ◽  
Tinku Thomas ◽  
Tivlin Maria ◽  
Kiron Varghese

Background: To evaluate the effects of baseline left ventricular restrictive filling pattern (RFP; E/A>2) in ischemic cardiomyopathy (ICM) patients on prognosis. Methods: Patient data was retrospectively analyzed over a period of 4.5 years to determine the effect of Echocardiographic factors on survival and re-admission for heart failure. Results: There were 102 ICM patients who had baseline RFP. We identified two sub-groups based on geometric phenotypes of left ventricular eccentric remodeling and dilated remodeling based on the relative wall thickness (RWT >0.34 or <0.34). The patients with preserved RWT had significantly more dilated ventricles ( LVIDd and LVIDs), greater pulmonary artery systolic pressures (PASP), greater diatolic dysfunction (E/A) and less left ventricular ejection fraction (LVEF); p<0.001. The number of deaths was higher in the reduced RWT patients, as were the number of re-admissions, although the time to survival and time to re-admission was not significant. Conclusions: In this pilot study on ICM patients in advanced heart failure with baseline RFP, the presence of preserved RWT indicative of eccentric remodelling demonstrated a better clinical outcome, leading to a hypothesis that the eccentric remodelling LV phenotype might benefit with SVR.


2021 ◽  
Author(s):  
Dino Miric ◽  
Ana Barac ◽  
Vesna Capkun ◽  
Darija Bakovic

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Giuseppe Muscogiuri ◽  
Francesca Ricci ◽  
Stefano Scafuri ◽  
Marco Guglielmo ◽  
Andrea Baggiano ◽  
...  

Author(s):  
Ali Fatehi Hassanabad ◽  
Kiana Wiebe ◽  
Imtiaz S. Ali

Author(s):  
Giuseppe Muscogiuri ◽  
Chiara Martini ◽  
Marco Gatti ◽  
Serena Dell'Aversana ◽  
Francesca Ricci ◽  
...  

2021 ◽  
Vol Volume 14 ◽  
pp. 5927-5937
Author(s):  
Jing Cao ◽  
Zhaoya Liu ◽  
Jie Liu ◽  
Chan Li ◽  
Guogang Zhang ◽  
...  

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