Effects of edaravone on pancreatic and renal injury in rats with severe acute pancreatitis

2020 ◽  
Vol 62 (2) ◽  
Author(s):  
Cunfu Liang ◽  
Qiang He ◽  
Fengxiao Ge ◽  
Xin Yin
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Renal Injury

Effect of mesenchymal stem cells on renal injury in rats with severe acute pancreatitis

2013 ◽  
Vol 238 (6) ◽  
pp. 687-695 ◽  
Author(s):  
Zhiyao Chen ◽  
Fengchun Lu ◽  
Haizong Fang ◽  
Heguang Huang
Keyword(s):  
Stem Cells ◽  
Acute Pancreatitis ◽  
Mesenchymal Stem Cells ◽  
Severe Acute Pancreatitis ◽  
Renal Injury

scholarly journals Severe acute pancreatitis-related renal injury in rats at different altitudes

2017 ◽  
Vol 25 (30) ◽  
pp. 2702-2707
Author(s):  
Bei-Bei He ◽  
Ya-Min Guo ◽  
Hai-Hong Zhu ◽  
Xiao Yang ◽  
Yun-Yan Bai
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Renal Injury ◽  
Different Altitudes

scholarly journals Hydrogen-Rich Saline Attenuates Acute Renal Injury in Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting ROS and NF-κB Pathway

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Qiao Shi ◽  
Kang-Shu Liao ◽  
Kai-Liang Zhao ◽  
Wei-Xing Wang ◽  
Teng Zuo ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Renal Injury ◽  
Redox Reactions ◽  
Sodium Taurocholate ◽  
Tyrosine Nitration ◽  
Protective Effects ◽  
Acute Renal Injury ◽  
Sod Activity ◽  
Proinflammatory Mediators

Hydrogen (H2), a new antioxidant, was reported to reduce•OH and ONOO−selectively and inhibit certain proinflammatory mediators to product, without disturbing metabolic redox reactions or ROS involved in cell signaling. We herein aim to explore its protective effects on acute renal injury in sodium taurocholate-induced acute pancreatitis and its possible mechanisms. Rats were injected with hydrogen-rich saline (HRS group) or normal saline (SO and SAP group) through tail intravenously (6 mL/kg) and compensated subcutaneously (20 mL/kg) after successful modeling. Results showed that hydrogen-rich saline attenuated the following: (1) serum Cr and BUN, (2) pancreatic and renal pathological injuries, (3) renal MDA, (4) renal MPO, (5) serum IL-1β, IL-6, and renal TNF-α, HMGB1, and (6) tyrosine nitration, IκB degradation, and NF-κB activation in renal tissues. In addition, it increased the level of IL-10 and SOD activity in renal tissues. These results proved that hydrogen-rich saline attenuates acute renal injury in sodium taurocholate-induced acute pancreatitis, presumably because of its detoxification activity against excessive ROS, and inhibits the activation of NF-κB by affecting IκB nitration and degradation. Our findings highlight the potential value of hydrogen-rich saline as a new therapeutic method on acute renal injury in severe acute pancreatitis clinically.

scholarly journals Clodronate-superparamagnetic iron oxide-containing liposomes attenuate renal injury in rats with severe acute pancreatitis

2014 ◽  
Vol 15 (6) ◽  
pp. 556-565 ◽  
Author(s):  
Sheng-chun Dang ◽  
Yan-hua Zeng ◽  
Ping-jiang Wang ◽  
Bao-ding Chen ◽  
Rong-fang Chen ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Iron Oxide ◽  
Severe Acute Pancreatitis ◽  
Renal Injury ◽  
Superparamagnetic Iron Oxide
Sign in / Sign up

Export Citation Format

Share Document