Background and Objective: Charles Bonnet Syndrome (CBS) has been defined as complex
visual hallucinations (CVH) due to visual loss. The underlying mechanism of CBS is not clear and the
underlying pathophysiology of the visual hallucinations in CBS patients and pure visually impaired
patients is still not clear.
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Methods: In our study, we have scanned three patients with eye disease and CBS (VH+) and three
patients with eye disease without CBS (VH-) using FDG-PET.
Results:
Our results showed underactivity in the pons and overactivity in primary right left visual cortex
and inferior parietal cortex in VH- patients and underactivity in left Broca, left inf frontal primary
visual cortex and anterior and posterior cingulate cortex in VH+ patients relative to the normative 18FFDG
PET data that was taken from the database consisting of 50 age-matched healthy adults without
neuropsychiatric disorders.
Conclusion:
From this distributed pattern of activity changes, we conclude that the generation of visual
hallucination in CBS is associated with bottom-up and top-down mechanism rather than the generally
accepted visual deafferentation-related hyperexcitability theory.