scholarly journals Geneti c Traits of Brachiocephalic Atherosclerosis

2021 ◽  
Vol 11 (4) ◽  
pp. 293-299
Author(s):  
A. F. Nurimanshin ◽  
R. R. Bogdanov ◽  
P. I. Mironov ◽  
A. A. Khusaenova
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Renin Angiotensin System ◽  
World Health ◽  
Vascular Lesions ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Atherosclerosis Development ◽  
Health Organization

Background. According to the World Health Organization, the atherosclerosis development depends on the quality of life and lifestyle (60 %), genetic (20 %), environmental factors (10 %) and quality of medical aid (5 %). The routes to defeat atherosclerosis generally and certain systemic enzyme disorders in particular pertain in research into the population genetic predispositions to this pathology.Materials and methods. A comparative study of genetic predispositions to malignant brachiocephalic atherosclerosis analysed the renin—angiotensin system gene association in 60 patients. Th e renin—angiotensin system allelic and polymorphic loci haplotype frequencies have been determined.Results and discussion. Patients with atherosclerotic brachiocephalic vascular lesions revealed a statistically significant frequency of the AGT gene’s allele C involved in coronary heart disease development.Conclusion. Th e study suggests a putative involvement of the angiotensinogen system genes in mediating the development of brachiocephalic atherosclerosis and coronary heart disease

scholarly journals Renin-angiotensin system gene polymorphisms and premature coronary heart disease

2005 ◽  
Vol 6 (1) ◽  
pp. 38-42 ◽  
Author(s):  
Cevad Sekuri ◽  
F Sirri Cam ◽  
Ertugrul Ercan ◽  
Istemihan Tengiz ◽  
Abdi Sagcan ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Gene Polymorphisms ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Premature Coronary Heart Disease

scholarly journals SARS-CoV-2/Renin–Angiotensin System: Deciphering the Clues for a Couple with Potentially Harmful Effects on Skeletal Muscle

2020 ◽  
Vol 21 (21) ◽  
pp. 7904
Author(s):  
Andrea Gonzalez ◽  
Josué Orozco-Aguilar ◽  
Oscar Achiardi ◽  
Felipe Simon ◽  
Claudio Cabello-Verrugio
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Renin Angiotensin System ◽  
Recovery Process ◽  
World Health ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Organ Systems ◽  
Health Organization ◽  
And Function

Severe acute respiratory syndrome coronavirus (SARS-CoV-2) has produced significant health emergencies worldwide, resulting in the declaration by the World Health Organization of the coronavirus disease 2019 (COVID-19) pandemic. Acute respiratory syndrome seems to be the most common manifestation of COVID-19. A high proportion of patients require intensive care unit admission and mechanical ventilation (MV) to survive. It has been well established that angiotensin-converting enzyme type 2 (ACE2) is the primary cellular receptor for SARS-CoV-2. ACE2 belongs to the renin–angiotensin system (RAS), composed of several peptides, such as angiotensin II (Ang II) and angiotensin (1-7) (Ang-(1-7)). Both peptides regulate muscle mass and function. It has been described that SARS-CoV-2 infection, by direct and indirect mechanisms, affects a broad range of organ systems. In the skeletal muscle, through unbalanced RAS activity, SARS-CoV-2 could induce severe consequences such as loss of muscle mass, strength, and physical function, which will delay and interfere with the recovery process of patients with COVID-19. This article discusses the relationship between RAS, SARS-CoV-2, skeletal muscle, and the potentially harmful consequences for skeletal muscle in patients currently infected with and recovering from COVID-19.

scholarly journals Genes of renin angiotensin system and coronary heart disease

2000 ◽  
Vol 15 (S1) ◽  
pp. 1-10 ◽  
Author(s):  
T. F. Ashavaid ◽  
K. K. Shalia ◽  
K. G. Nair ◽  
J. J. Dalal
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

scholarly journals Renin angiotensin system inhibition is associated with reduced free radical concentrations in arteries of patients with coronary heart disease

Heart ◽  
2001 ◽  
Vol 86 (2) ◽  
pp. 217-220
Author(s):  
COLIN BERRY ◽  
NIALL ANDERSON ◽  
ALAN J B KIRK ◽  
ANNA F DOMINICZAK ◽  
JOHN J V MCMURRAY
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Free Radical ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

scholarly journals Modulation of Sympathetic Coronary Vasoconstriction by Cardiac Renin-Angiotensin System in Human Coronary Heart Disease

Circulation ◽  
2000 ◽  
Vol 101 (19) ◽  
pp. 2277-2283 ◽  
Author(s):  
Antonio Saino ◽  
Guido Pomidossi ◽  
Rodolfo Perondi ◽  
Alberto Morganti ◽  
Lucia Turolo ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Coronary Vasoconstriction ◽  
Renin Angiotensin

scholarly journals Evidence for Use or Disuse of Renin–Angiotensin System Modulators in Patients Having COVID-19 With an Underlying Cardiorenal Disorder

2020 ◽  
Vol 25 (4) ◽  
pp. 299-306 ◽  
Author(s):  
Himanshu Sankrityayan ◽  
Ajinath Kale ◽  
Nisha Sharma ◽  
Hans-Joachim Anders ◽  
Anil Bhanudas Gaikwad
Keyword(s):  
Kidney Diseases ◽  
Renin Angiotensin System ◽  
Heart Association ◽  
Potential Effect ◽  
World Health ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Health Organization ◽  
Ras Inhibitors

Coronavirus disease 19 (COVID-19) originated in Wuhan, China, in December 2019 has been declared pandemic by World Health Organization due to an exponential rise in the number of infected and deceased persons across the globe. Emerging reports suggest that susceptibility and mortality rates are higher in patients with certain comorbidities when compared to the average population. Cardiovascular diseases and diabetes are important risk factors for a lethal outcome of COVID-19. Extensive research ensuing the outbreak of coronavirus-related severe acute respiratory syndrome in the year 2003, and COVID-19 recently revealed a role of renin–angiotensin system (RAS) components in the entry of coronavirus wherein angiotensin-converting enzyme 2 (ACE2) had garnered the significant attention. This raises the question whether the use of RAS inhibitors, the backbone of treatment of cardiovascular, neurovascular, and kidney diseases could increase the susceptibility for coronavirus infection or unfortunate outcomes of COVID-19. Thus, currently, there is a lack of consensus regarding the effects of RAS inhibitors in such patients. Moreover, expert bodies like American Heart Association, American College of Cardiology, and so on have now released official statements that RAS inhibitors must be continued, unless suggested otherwise by a physician. In this brief review, we will elaborate on the role of RAS and ACE2 in pathogenesis of COVID-19. Moreover, we will discuss the potential effect of the use and disuse of RAS inhibitors in patients having COVID-19 with cardiometabolic comorbidities.

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