scholarly journals PATHOGENETIC SUBSTANTIATION OF L-ARGININE APPLICATION AT COMBINED CLINICAL COURSE OF NON-ALCOHOLIC STEATOHEPATITIS AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE TAKING INTO ACCOUNT POLYMORPHOUS VARIANT G894T OF THE GENE OF ENDOTHELIAL NO-SYNTHASE

2017 ◽  
Vol 16 (3) ◽  
Author(s):  
T. P. Tsyntar
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Clinical Course ◽  
No Synthase ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Endothelial No Synthase ◽  
Alcoholic Steatohepatitis

scholarly journals A relationship between chronic obstructive pulmonary disease, obesity and melatonin level

2018 ◽  
Vol 28 (3) ◽  
pp. 359-367 ◽  
Author(s):  
A. V. Budnevskiy ◽  
Е. S. Ovsyannikov ◽  
Ya. S. Shkatova
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Systemic Inflammation ◽  
Clinical Course ◽  
Antioxidant Activities ◽  
Blood Levels ◽  
Chronic Obstructive ◽  
Melatonin Level ◽  
Bronchial Obstruction ◽  
Obstructive Pulmonary Disease

This is a review of experimental and clinical studies investigated effects of obesity on clinical course of chronic obstructive pulmonary disease (COPD); pathophysiological mechanisms of this effect, and relationships between melatonin level and the course of COPD have been also discussed. Associations between severity of COPD, rate of exacerbations and blood levels of most important adipokines, such as leptin and adiponectin, and relationships between melatonin levels and those adipokines were published. Conflicting results were obtained in studies of effects of obesity on clinical course of COPD. The "obesity paradox", that is a reduction in mortality and milder bronchial obstruction in obese COPD patients, has been identified in several studies. Despite contradictory results, obesity is likely to improve prognosis of COPD due to decrease in the systemic inflammation. Levels of leptin and adiponectin increase in acute exacerbation of COPD and then decrease to the baseline. Moreover, melatonin is suggested to play a great role for COPD course, mostly due to antiinflammatory and antioxidant activities. According to results of several studies, melatonin could affect blood levels of adiponectin and lectin; this could indirectly influence on the systemic inflammation in COPD. Further studies are needed to elicit these relationships. 

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