Effects of topical instillation of 0.1% diclofenac sodium, 0.5% ketorolac tromethamine, and 0.03% flurbiprofen sodium on corneal sensitivity in ophthalmologically normal cats

2021 ◽  
Vol 82 (1) ◽  
pp. 81-87
Author(s):  
Jordan K. Roberts ◽  
Jessica M. Meekins ◽  
James K. Roush ◽  
Amy J. Rankin
Keyword(s):  
Diclofenac Sodium ◽  
Ketorolac Tromethamine ◽  
Corneal Sensitivity

scholarly journals Effects of topical flurbiprofen sodium, diclofenac sodium, ketorolac tromethamine and benzalkonium chloride on corneal sensitivity in normal dogs

2017 ◽  
Vol 7 (3) ◽  
pp. 254 ◽  
Author(s):  
Raquel de Araújo Cantarella ◽  
Juliana Kravetz De Oliveira ◽  
Daniel M. Dorbandt ◽  
Fabiano Montiani-Ferreira
Keyword(s):  
Benzalkonium Chloride ◽  
Diclofenac Sodium ◽  
Ketorolac Tromethamine ◽  
Corneal Sensitivity ◽  
Sodium Diclofenac

Comparison of ketorolac tromethamine, diclofenac sodium, and moist drops for ocular pain after radial keratotomy

1999 ◽  
Vol 25 (8) ◽  
pp. 1097-1108 ◽  
Author(s):  
Marguerite B. McDonald ◽  
Stephen F. Brint ◽  
Daniel I. Caplan ◽  
Linda B. Bourque ◽  
Kimberly Shoaf
Keyword(s):  
Diclofenac Sodium ◽  
Ketorolac Tromethamine ◽  
Ocular Pain ◽  
Radial Keratotomy

scholarly journals 3425 Effect of the topical administration of diclofenac sodium and indomethacin on corneal sensitivity in normal subjects

1995 ◽  
Vol 35 ◽  
pp. S146
Author(s):  
P. Aragona ◽  
I. Fragala' ◽  
F.C. Oteri ◽  
F. Battaglia ◽  
G. Ferreri
Keyword(s):  
Diclofenac Sodium ◽  
Normal Subjects ◽  
Topical Administration ◽  
Corneal Sensitivity

scholarly journals Systemic absortion and adverse effects of topical ocular use of ketorolac tromethamine and sodium diclofenac in New Zealand rabbits for 90 days

2019 ◽  
Vol 71 (6) ◽  
pp. 1865-1872 ◽  
Author(s):  
F.Q. Pereira ◽  
B. Santos ◽  
T. Carboni ◽  
M. Bender ◽  
D. Driemeier ◽  
...  
Keyword(s):  
New Zealand ◽  
Solid Phase ◽  
Diclofenac Sodium ◽  
Systemic Absorption ◽  
Ketorolac Tromethamine ◽  
Nacl Solution ◽  
Laboratory Examination ◽  
New Zealand White Rabbits ◽  
Laboratory Results ◽  
And Control

ABSTRACT The effect of the systemic absorption of 0.1% diclofenac sodium (DS) eyedrop was compared to that of 0.5% ketorolac tromethamine (KT) in female New Zealand white rabbits treated on both eyes three times a day for 90 days. The rabbits were divided in three groups of six animals (n= 18): KT group, DS group, and control (Co) group, in which saline (0.9% NaCl) solution was instilled. Water and food consumption were measured daily, clinical examination was performed weekly, and blood samples were collected every 30 days for laboratory examination. The plasma was analyzed for the presence of KT and DS by solid-phase extraction (SPE) associated with mass spectrometry (MS). Systemic absorption of these drugs was confirmed by SPE-MS, allowing their separation and identification in the plasma. At the end of the treatment, the animals were euthanized and necropsied, and no macroscopic or microscopic changes were found. This observation confirmed the laboratory results, which were within normal reference standards for the species. According to the results obtained, it can be concluded that treatment with eyedrops containing KT and DS for 90 days in healthy rabbits does not cause adverse systemic effects.

EFFECT OF TOPICAL KETOROLAC TROMETHAMINE ON NORMAL CORNEAL SENSITIVITY

1995 ◽  
Vol 72 (SUPPLEMENT) ◽  
pp. 137
Author(s):  
Wylie Tirey ◽  
Nancy Guill Johnson
Keyword(s):  
Ketorolac Tromethamine ◽  
Corneal Sensitivity

Decrease in Normal Human Corneal Sensitivity With Topical Diclofenac Sodium

1994 ◽  
Vol 118 (3) ◽  
pp. 312-315 ◽  
Author(s):  
Karin Szerenyi ◽  
Kris Sorken ◽  
Jenny J. Garbus ◽  
Martha Lee ◽  
Peter J. McDonnell
Keyword(s):  
Diclofenac Sodium ◽  
Corneal Sensitivity ◽  
Normal Human ◽  
Topical Diclofenac

Comparison of Ketorolac Tromethamine with Other Injectable Nonsteroidal Anti-Inflammatory Drugs for Pain-on-Injection and Muscle Damage in the Rat

1994 ◽  
Vol 13 (2) ◽  
pp. 111-117 ◽  
Author(s):  
Gary J. Chellman ◽  
Lance O. Lollini ◽  
Albert E. Dorr ◽  
Linval R. DePass
Keyword(s):  
Muscle Damage ◽  
Diclofenac Sodium ◽  
Isotonic Saline ◽  
The Other ◽  
Ketorolac Tromethamine ◽  
Clinical Use ◽  
Local Tolerance ◽  
Pain On Injection ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

The local tolerance of ketorolac tromethamine (Toradol®, Syntex) was compared with that of four other injectable nonsteroidal anti-inflammatory drugs (NSAIDs) (diclofenac sodium, piroxicam, ketoprofen, and metamizol magnesium) in the rat paw-lick/muscle irritation assay as described previously,1 All drugs were tested at concentrations approved for clinical use. After subplantar (footpad) injection, ketorolac produced virtually no pain-on-injection as assessed by the number of paw-lick/lift responses during a 15 min observation period. The other NSAIDs produced slight to moderate paw-lick/lift responses. Redness and swelling at the injection site were less severe for ketorolac than for the other NSAIDs, After intramuscular (i.m.) injection, all of the. NSAIDs produced some degree of muscle damage, as assessed histopathologically 24 h after injection. The lesions, consisting primarily of muscle degeneration, were less severe for ketorolac than for the other NSAIDs. Ketorolac and metamizol produced the smallest elevations in serum creatine kinase, as measured 2 h after i.m. dosing, not significantly different from isotonic saline. Overall, ketorolac was better tolerated in the assay than the other injectable NSAIDs, thereby suggesting the possibility of improved local tolerance on clinical use.

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