A Randomized Double-Masked Trial Comparing Ketorolac Tromethamine 0.5%, Diclofenac Sodium 0.1%, and Prednisolone Acetate 1% in Reducing Post-Phacoemulsification Flare and Cells

Purpose. This study was performed to compare the efficacy, safety and tolerability of diclofenac sodium 0.1 % ophthalmic solution with that of prednisolone acetate 1.0% ophthalmic suspension for treatment of inflammation following phacoemulsification and posterior chamber lens implantation. Methods. One hundred and sixteen patients (diclofenac 57, prednisolone 59) with visually disabling cataract were enrolled in this prospective, randomised, double-masked, parallel group study in two centres. Post-operative patient assessments at day 1, 5–8 and 12–16 included visual acuity, slit-lamp examination, applanation tonometry and subjective evaluation of local tolerance. Results. There was no statistically significant difference between the diclofenac and prednisolone groups in the sum of the grades of anterior chamber flare and cells or the degree of conjunctival hyperaemia at any study visit. The overall assessment of local tolerance was similar for both the study medications. There were two (3.4%) possibly drug-related adverse events in the prednisolone group but neither was severe. Conclusions. Diclofenac sodium 0.01% ophthalmic solution was as effective, safe and well tolerated overall as prednisolone acetate 1.0% ophthalmic suspension.

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Comparison of ketorolac tromethamine, diclofenac sodium, and moist drops for ocular pain after radial keratotomy

Journal of Cataract & Refractive Surgery ◽

10.1016/s0886-3350(99)00116-9 ◽

1999 ◽

Vol 25 (8) ◽

pp. 1097-1108 ◽

Cited By ~ 11

Author(s):

Marguerite B. McDonald ◽

Stephen F. Brint ◽

Daniel I. Caplan ◽

Linda B. Bourque ◽

Kimberly Shoaf

Keyword(s):

Diclofenac Sodium ◽

Ketorolac Tromethamine ◽

Ocular Pain ◽

Radial Keratotomy

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Systemic absortion and adverse effects of topical ocular use of ketorolac tromethamine and sodium diclofenac in New Zealand rabbits for 90 days

Arquivo Brasileiro de Medicina Veterinária e Zootecnia ◽

10.1590/1678-4162-10219 ◽

2019 ◽

Vol 71 (6) ◽

pp. 1865-1872 ◽

Cited By ~ 1

Author(s):

F.Q. Pereira ◽

B. Santos ◽

T. Carboni ◽

M. Bender ◽

D. Driemeier ◽

...

Keyword(s):

New Zealand ◽

Solid Phase ◽

Diclofenac Sodium ◽

Systemic Absorption ◽

Ketorolac Tromethamine ◽

Nacl Solution ◽

Laboratory Examination ◽

New Zealand White Rabbits ◽

Laboratory Results ◽

And Control

ABSTRACT The effect of the systemic absorption of 0.1% diclofenac sodium (DS) eyedrop was compared to that of 0.5% ketorolac tromethamine (KT) in female New Zealand white rabbits treated on both eyes three times a day for 90 days. The rabbits were divided in three groups of six animals (n= 18): KT group, DS group, and control (Co) group, in which saline (0.9% NaCl) solution was instilled. Water and food consumption were measured daily, clinical examination was performed weekly, and blood samples were collected every 30 days for laboratory examination. The plasma was analyzed for the presence of KT and DS by solid-phase extraction (SPE) associated with mass spectrometry (MS). Systemic absorption of these drugs was confirmed by SPE-MS, allowing their separation and identification in the plasma. At the end of the treatment, the animals were euthanized and necropsied, and no macroscopic or microscopic changes were found. This observation confirmed the laboratory results, which were within normal reference standards for the species. According to the results obtained, it can be concluded that treatment with eyedrops containing KT and DS for 90 days in healthy rabbits does not cause adverse systemic effects.

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Effect of preoperative use of topical prednisolone acetate, ketorolac tromethamine, nepafenac and placebo, on the maintenance of intraoperative mydriasis during cataract surgery: A randomized trial

Indian Journal of Ophthalmology ◽

10.4103/0301-4738.98705 ◽

2012 ◽

Vol 60 (4) ◽

pp. 277 ◽

Cited By ~ 15

Author(s):

Rodrigo PessoaCavalcanti Lira ◽

FernandoRoberte Zanetti ◽

Carlos EduardoLeite Arieta ◽

Fernando RodrigoPedreira Chaves ◽

AlexandrePaashaus da Costa Pinto ◽

...

Keyword(s):

Cataract Surgery ◽

Randomized Trial ◽

Prednisolone Acetate ◽

Ketorolac Tromethamine

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Comparison of the morphine-sparing effects of diclofenac sodium and ketorolac tromethamine after major orthopedic surgery

Journal of Clinical Anesthesia ◽

10.1016/s0952-8180(01)00382-8 ◽

2002 ◽

Vol 14 (3) ◽

pp. 187-192 ◽

Cited By ~ 55

Author(s):

Ratan Alexander ◽

Habib E. El-Moalem ◽

Tong J. Gan

Keyword(s):

Orthopedic Surgery ◽

Diclofenac Sodium ◽

Ketorolac Tromethamine ◽

Major Orthopedic Surgery

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Effects of topical flurbiprofen sodium, diclofenac sodium, ketorolac tromethamine and benzalkonium chloride on corneal sensitivity in normal dogs

Open Veterinary Journal ◽

10.4314/ovj.v7i3.9 ◽

2017 ◽

Vol 7 (3) ◽

pp. 254 ◽

Cited By ~ 2

Author(s):

Raquel de Araújo Cantarella ◽

Juliana Kravetz De Oliveira ◽

Daniel M. Dorbandt ◽

Fabiano Montiani-Ferreira

Keyword(s):

Benzalkonium Chloride ◽

Diclofenac Sodium ◽

Ketorolac Tromethamine ◽

Corneal Sensitivity ◽

Sodium Diclofenac

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Comparison of Ketorolac Tromethamine with Other Injectable Nonsteroidal Anti-Inflammatory Drugs for Pain-on-Injection and Muscle Damage in the Rat

Human & Experimental Toxicology ◽

10.1177/096032719401300209 ◽

1994 ◽

Vol 13 (2) ◽

pp. 111-117 ◽

Cited By ~ 6

Author(s):

Gary J. Chellman ◽

Lance O. Lollini ◽

Albert E. Dorr ◽

Linval R. DePass

Keyword(s):

Muscle Damage ◽

Diclofenac Sodium ◽

Isotonic Saline ◽

The Other ◽

Ketorolac Tromethamine ◽

Clinical Use ◽

Local Tolerance ◽

Pain On Injection ◽

Inflammatory Drugs ◽

Anti Inflammatory

The local tolerance of ketorolac tromethamine (Toradol®, Syntex) was compared with that of four other injectable nonsteroidal anti-inflammatory drugs (NSAIDs) (diclofenac sodium, piroxicam, ketoprofen, and metamizol magnesium) in the rat paw-lick/muscle irritation assay as described previously,1 All drugs were tested at concentrations approved for clinical use. After subplantar (footpad) injection, ketorolac produced virtually no pain-on-injection as assessed by the number of paw-lick/lift responses during a 15 min observation period. The other NSAIDs produced slight to moderate paw-lick/lift responses. Redness and swelling at the injection site were less severe for ketorolac than for the other NSAIDs, After intramuscular (i.m.) injection, all of the. NSAIDs produced some degree of muscle damage, as assessed histopathologically 24 h after injection. The lesions, consisting primarily of muscle degeneration, were less severe for ketorolac than for the other NSAIDs. Ketorolac and metamizol produced the smallest elevations in serum creatine kinase, as measured 2 h after i.m. dosing, not significantly different from isotonic saline. Overall, ketorolac was better tolerated in the assay than the other injectable NSAIDs, thereby suggesting the possibility of improved local tolerance on clinical use.

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