3425 Effect of the topical administration of diclofenac sodium and indomethacin on corneal sensitivity in normal subjects

ABSTRACT The effect of two inhibitors of prostaglandin synthetase activity (acetylsalicylic acid (ASA) and diclofenac sodium (DCFS)) on plasma renin activity (PRA) and plasma aldosterone (PA) was studied in normal subjects kept on a diet with constant sodium and potassium intake or on a low-salt diet for 7 days. In 9 subjects, 2 days of treatment with ASA (3 g/day) was followed by a significant decrease of PA in the supine position (after overnight rest); there was no significant decrease of PRA. However, both PA and PRA with the subjects in the upright position were significantly reduced after ASA. In 9 subjects treated with DCFS (200 mg for 2 days), both PA and PRA with the subjects in the supine and upright positions decreased significantly. Similar results were obtained from 4 subjects on a low-sodium diet (15–30 mEq./day) treated with DCFS (150 mg/day for 3 days). In contrast, no significant changes in PA or PRA with the subjects in the supine or upright position were observed in 4 subjects on a very low sodium diet (< 15 mEq./day) treated with DCFS (150 mg/day for 3 days). Covariance analysis (with PRA as independent variable and PA as dependent variable) of the data obtained in the upright position before and after treatment with ASA or DCFS showed that the decrease in PA remained significant after adjustment for the PRA effect. These results suggest a direct effect of prostaglandins on PA. The data obtained from subjects on a low sodium diet indicate that sodium deprivation may counteract the effects of DCFS on PRA and PA.

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Decrease in Normal Human Corneal Sensitivity With Topical Diclofenac Sodium

American Journal of Ophthalmology ◽

10.1016/s0002-9394(14)72954-x ◽

1994 ◽

Vol 118 (3) ◽

pp. 312-315 ◽

Cited By ~ 47

Author(s):

Karin Szerenyi ◽

Kris Sorken ◽

Jenny J. Garbus ◽

Martha Lee ◽

Peter J. McDonnell

Keyword(s):

Diclofenac Sodium ◽

Corneal Sensitivity ◽

Normal Human ◽

Topical Diclofenac

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Effects of topical flurbiprofen sodium, diclofenac sodium, ketorolac tromethamine and benzalkonium chloride on corneal sensitivity in normal dogs

Open Veterinary Journal ◽

10.4314/ovj.v7i3.9 ◽

2017 ◽

Vol 7 (3) ◽

pp. 254 ◽

Cited By ~ 2

Author(s):

Raquel de Araújo Cantarella ◽

Juliana Kravetz De Oliveira ◽

Daniel M. Dorbandt ◽

Fabiano Montiani-Ferreira

Keyword(s):

Benzalkonium Chloride ◽

Diclofenac Sodium ◽

Ketorolac Tromethamine ◽

Corneal Sensitivity ◽

Sodium Diclofenac

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Ototoxicity associated with topical administration of diclofenac sodium as an otic drop: An experimental animal study

International Journal of Pediatric Otorhinolaryngology ◽

10.1016/j.ijporl.2017.04.039 ◽

2017 ◽

Vol 98 ◽

pp. 110-115 ◽

Cited By ~ 3

Author(s):

Engin Acioglu ◽

Ozgur Yigit ◽

Firat Onur ◽

Ahmet Atas ◽

Ela Araz Server ◽

...

Keyword(s):

Animal Study ◽

Experimental Animal ◽

Diclofenac Sodium ◽

Topical Administration ◽

Experimental Animal Study

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Anti-Inflammatory Activity of Mangosteen (Garcinia Mangostana Linn.) Rind Extract Nanoemulgel and Gel Dosage Forms

Biomedical & Pharmacology Journal ◽

10.13005/bpj/1807 ◽

2019 ◽

Vol 12 (04) ◽

pp. 1767-1774

Author(s):

Ketut Widyani Astuti ◽

Ni Putu Ayu Dewi Wijayanti ◽

Putu Sanna Yustiantara ◽

Komang Puja Laksana ◽

Putu Surya Anggara Putra

Keyword(s):

Diclofenac Sodium ◽

Chemical Properties ◽

Topical Administration ◽

Dosage Forms ◽

Inflammatory Activity ◽

Garcinia Mangostana ◽

Reference Drug ◽

Anti Inflammatory ◽

The Difference ◽

Physical And Chemical

Mangosteen (Garcinia mangostana Linn.) rind is known for its anti-inflammatory activity. Inflammation of local tissue can be overcome by topical administration of dosage forms. In an effort to improve the quality of topical drug delivery, nanoparticle technology can be an option.The purpose of this study is to determine the activity of gel and nanoemulgel dosage forms containing fractions of mangosteen rind extract (n-hexane: ethyl acetate). The gel dosage form of mangosteen rind fractions was successfully prepared. Its physical and chemical properties were evaluated, and the results were within the expected range. The spreadibility of the formulations was between 5-7cm and the pH was between 4.5 and 6.5.The 0.0625% and 0.125% mangosteen rind fraction concentrations are the formulas by which nanoemulgel was successfully formed, resulting in non-separating phases, percent transmittance of 96.997 ± 0.137% and 94.253 ± 0.134% respectively, particle size of 17.437 ± 0.427 and 17.240 ± 0.276 nm; potential zeta of 5.183 ± 0.202 and -10.143 ± 0.238. In the inflammatory test of carrageenan induced laboratory mice, nanoemulgel containing 0.0625% and 0.125% mangosteen rind fraction concentrations produced better percent inhibition (p<0.05) compared to gel containing 0.1%, 0.5%, and 1% mangosteen rind fraction concentrationsin the 90th minute, but the difference was not significant in the 120thminute through the end of thetest. The nanoemulgel containing 0.0625% and 0.125% mangosteen rind fraction concentrations have an unsignificant difference in results (p>0.05) when compared to the reference drug (diclofenac sodium) in the 90th minute.

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