Spatial Discrimination Reversal Learning for Mice Genetically Selected for Differing Brain Size: A Supplementary Report

1970 ◽  
Vol 30 (1) ◽  
pp. 239-245 ◽  
Author(s):  
Merrill F. Elias
Keyword(s):  
Reversal Learning ◽  
Water Maze ◽  
Brain Size ◽  
Discrimination Reversal ◽  
Spatial Discrimination ◽  
Control Line ◽  
Positive Relation ◽  
High Brain ◽  
High Line ◽  
Supplementary Report

Spatial discrimination reversal learning was explored for mice genetically selected for high brain weight and unselected controls with lower brain weights. Control-line Ss escaped from a water maze more rapidly, but high-line Ss made fewer errors and took less trials to reach criterion on the first reversal. Control-line Ss were unable to complete more than 1 reversal, while high-line Ss all completed at least 7 reversals. This positive relation between reversal learning and brain size is consistent with comparisons among species and experiments manipulating brain size by means of drugs or surgery.

Differences in Spatial Discrimination Reversal Learning for Mice Genetically Selected for High Brain Weight and Unselected Controls

1969 ◽  
Vol 28 (3) ◽  
pp. 707-712 ◽  
Author(s):  
Merrill F. Elias
Keyword(s):  
Reversal Learning ◽  
Water Maze ◽  
Brain Size ◽  
Original Learning ◽  
Brain Weight ◽  
Discrimination Reversal ◽  
Spatial Discrimination ◽  
Positive Relation ◽  
High Brain ◽  
Spatial Reversal

Spatial reversal learning was explored for mice genetically selected for high brain weight and unselected control mice with lower brain weights. Original learning and two reversals were presented in a water maze. There were no differences for original learning, but the high brain-weight mice were superior to the unselected controls for both reversals. Since all controls had lower brain weights than the highs, it was concluded that these data support a positive relation between brain size and spatial reversal learning.

Effects of Retinal Degeneration and Brain Size upon Spatial Reversal Learning in Mice

1973 ◽  
Vol 36 (3) ◽  
pp. 947-950 ◽  
Author(s):  
John L. Fuller ◽  
Susan Brady-Wood ◽  
Merrill F. Elias
Keyword(s):  
Retinal Degeneration ◽  
Reversal Learning ◽  
Brain Size ◽  
Brain Weight ◽  
Spatial Discrimination ◽  
High Brain ◽  
Spatial Reversal ◽  
Initial Learning

Mice selected for high brain weight were superior to unselected controls in initial and reversal learning of a spatial discrimination in a water T-maze. Mice selected for low brain weight were superior to controls on initial learning but not on reversals. The presence of retinal degeneration in the low line and in some controls was not an important factor in performance in this maze.

scholarly journals SELECTION FOR BLOOD PRESSURE LEVELS IN MICE

Genetics ◽  
1974 ◽  
Vol 76 (3) ◽  
pp. 537-549
Author(s):  
Gunther Schlager
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Genetic Variance ◽  
Additive Genetic Variance ◽  
Population Bottleneck ◽  
Control Line ◽  
Selected Lines ◽  
High Line ◽  
Selection For ◽  
Random Control

ABSTRACT Response to two-way selection for systolic blood pressure was immediate and continuous for about eight generations. In the twelfth generation, the High males differed from the Low males by 38 mmHG; the females differed by 39 mmHg. There was little overlap between the two lines and they were statistically significant from each other and from the Random control line. There appeared to be no more additive genetic variance in the eleventh and twelfth generations. Causes for the cessation of response are explored. This is probably due to a combination of natural selection acting to reduce litter sizes in the Low line, a higher incidence of sudden deaths in the High line, and loss of favorable alleles as both selection lines went through a population bottleneck in the ninth generation.—In the eleventh generation, the selected lines were used to produce F1, F2, and backcross generations. A genetic analysis yielded significant additive and dominance components in the inheritance of systolic blood pressure.

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