Differences in Spatial Discrimination Reversal Learning for Mice Genetically Selected for High Brain Weight and Unselected Controls

Spatial reversal learning was explored for mice genetically selected for high brain weight and unselected control mice with lower brain weights. Original learning and two reversals were presented in a water maze. There were no differences for original learning, but the high brain-weight mice were superior to the unselected controls for both reversals. Since all controls had lower brain weights than the highs, it was concluded that these data support a positive relation between brain size and spatial reversal learning.