Basal Cell Carcinoma Arising within a Trichoepithelioma: An Immunohistochemical Study

AbstractBackground: Trichoepithelioma (TE) and basal cell carcinoma (BCC) of skin represent distinct tumor entities but they have a close histogenetic and phenotypic relationship.Objective: A unique case of a BCC arising within a TE is described with an emphasis on the analysis of different and for each tumor type typical immunophenotype.Material and Methods: A 71-year-old man presented with a subcutaneous solid tumor in the lumbar region. The resected tumor specimen was studied by immunohistochemistry.Results: Histology revealed a coexistence of classic TE and nodular BCC. Both tumors were strongly positive for BerEP4 and negative for EMA. Neoplastic epithelium of the BCC showed a diffuse staining for Bcl-2, while the TE expressed Bcl-2 almost exclusively in the peripheral cells of tumor islands. In the BCC, neoplastic nodules exhibited a focal staining for CD10, while the peritumorous stroma did not. In contrast, the TE showed a focal immunoreactivity for CD10 in the stromal cells around the neoplastic islands which were completely negative. The TE contained intratumorous CK20-labeled Merkel cells but they were not detected in the BCC. A stromal immunore-activity for CD34 was found in both tumors. Proliferative activity (Ki-67) was slightly higher in the BCC than in the TE.Conclusion: Although a concomitant presence of TE and BCC in the same skin lesion is a unique finding, it may be sometimes encountered in a biopsy practice. Pathologists should provide a careful histologic examination of the whole TE lesion with precise section sampling to unveil such possible association.

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Metastatic Basal Cell Carcinoma: Four Case Reports, Review of Literature, and Immunohistochemical Evaluation

Archives of Pathology & Laboratory Medicine ◽

10.5858/2006-130-45-mbccfc ◽

2006 ◽

Vol 130 (1) ◽

pp. 45-51

Author(s):

Diana N. Ionescu ◽

Muammar Arida ◽

Drazen M. Jukic

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Case Reports ◽

Small Sample ◽

Ki 67 ◽

Immunohistochemical Markers ◽

Metastatic Basal Cell Carcinoma ◽

Metastatic Sites

Abstract Context.—Metastatic basal cell carcinoma (BCC) is relatively rare and is seldom considered a complication in the routine treatment and follow-up of patients with BCC. Although multiple studies have tried to distinguish aggressive from nonaggressive BCCs, to our knowledge, no consistent clinical, histopathologic, or immunohistochemical features have yet been reported. Objective.—To report 4 cases of metastatic BCCs and to evaluate these in addition to known nonmetastatic BCCs with specific immunostains in an attempt to find distinct morphologic or immunohistochemical patterns that could be helpful in identifying aggressive BCCs. Design.—We reviewed 4 cases of metastatic BCCs and recorded the clinical and morphologic findings. We then searched our archives for 14 cases of BCC that followed the usual nonaggressive course. We evaluated these 18 cases with immunohistochemical stains for Ki-67, p53, and bcl-2. Results.—In metastasizing BCC, Ki-67 staining was slightly higher in metastatic sites than in primary sites (average 63% and 51%, respectively). p53 was expressed in 3 of 4 primary sites and 2 of 4 metastatic sites. Bcl-2 was positive in both primary and metastatic sites in 3 of 4 cases. In the 14 cases of nonaggressive BCC, staining for Ki-67 averaged 38%, p53 was positive in 11 cases, and Bcl-2 staining was noted in 13 cases. Conclusions.—Overall, in the small sample that we evaluated, the immunohistochemical markers for Ki-67, p53, and Bcl-2 did not distinguish between metastatic and nonaggressive BCCs.

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Immunohistochemical evaluation of trichoepithelioma and basal cell carcinoma using Ki-67

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2015.02.348 ◽

2015 ◽

Vol 72 (5) ◽

pp. AB84

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Ki 67

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Prostate Basal Cell Carcinoma: A Case Report

Case Reports in Oncology ◽

10.1159/000487389 ◽

2018 ◽

Vol 11 (1) ◽

pp. 138-142 ◽

Cited By ~ 1

Author(s):

Sahoko Ninomiya ◽

Takashi Kawahara ◽

Hiromichi Iwashita ◽

Genta Iwamoto ◽

Daiji Takamoto ◽

...

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Immunohistochemical Analysis ◽

Pathological Examination ◽

Ki 67 ◽

Prostate Hyperplasia ◽

Atypical Cells ◽

Prostate Cancers ◽

Benign Prostate

Prostate basal cell carcinoma (PBCC) accounts for 0.01% of all prostate cancers. A 68-year-old man complained of dysuria for 5 years on his initial visit. His PSA level was 3.87 ng/mL. Due to a diagnosis of benign prostate hyperplasia, he underwent transurethral resection of the prostate. A pathological examination revealed that basal cell-like atypical cells made alveolar with palisadal layout. Immunohistochemical analysis showed positive 34β12, P63, and Ki-67. Based on these findings, PBCC was diagnosed. Then, we performed radical prostatectomy. He was free from recurrence 22 months after the operation. We herein report an extremely rare case of PBCC.

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Coexisting Basal Cell Carcinoma and Squamous Cell Carcinoma in Congenital Nevus Sebaceous

SKIN The Journal of Cutaneous Medicine ◽

10.25251/skin.2.3.6 ◽

2018 ◽

Vol 2 (3) ◽

pp. 181-185

Author(s):

Jordan Rosen ◽

Katherine Nolan ◽

Noah Shaikh ◽

Les Rosen ◽

Martin Zaiac

Keyword(s):

Squamous Cell Carcinoma ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Basal Cell ◽

Squamous Cell Carcinomas ◽

Malignant Neoplasms ◽

Rare Occurrence ◽

Unique Case ◽

Nevus Sebaceous

Nevus sebaceous is a congenital epidermal hamartoma characterized by hyperplastic changes to the epidermis and adnexa. Nevus sebaceous is associated with an elevated risk of cutaneous neoplasms, most often benign; however, malignant neoplasms, most notably basal cell carcinoma, can also present in these patients. Although a rare occurrence, more often affecting adult patients, squamous cell carcinomas have also been reported to arise at the site of pre-existing nevus sebaceous. Herein we report a unique case of a patient with basal cell carcinoma and squamous cell carcinoma arising concurrently in the same nevus sebaceous.

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Nonsyndromic Type of Multiple Basal Cell Carcinoma

International Journal of Head and Neck Surgery ◽

10.5005/jp-journals-10001-1005 ◽

2010 ◽

Vol 1 (1) ◽

pp. 25-28

Author(s):

D'Cruz Anil ◽

Chaturvedi Pankaj ◽

Chaukar Devendra ◽

Ghatge Amit ◽

Pai Prathamesh ◽

...

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Chemical Warfare ◽

Unique Case ◽

Actinic Keratoses ◽

The Face ◽

Multiple Variable ◽

History Of ◽

Indian Male

Abstract We report a case of nonsyndromic type of multiple basal cell carcinoma associated purely with actinic keratoses. A 69-year-old Indian male had suffered from multiple, variable-sized papules and nodules on the face, neck and chest for 13 years previous to treatment. He had no history of arsenic intake, irradiation, herb medication, or exposure to chemical warfare gases. Family histories for basal cell carcinoma and xeroderma pigmentosum were negative. Classical features of Gorlin's syndrome were conspicuous by their absence. Histopathologically, the tumors revealed typical findings of basal cell carcinoma arising from actinic keratoses. The case in point is a very rare and unique case in itself as being nonsyndromic, nonhereditary and occurring in the absence of various other environmental conditions as already mentioned in literature.

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Optical Biopsy of Amelanotic Melanoma with Raman and Autofluorescence Spectra Stimulated by 785 nm Laser Excitation

Journal of Biomedical Photonics & Engineering ◽

10.18287/jbpe21.07.020308 ◽

2021 ◽

Vol 7 (2) ◽

pp. 020308

Author(s):

Ivan Bratchenko ◽

Yulia Khristoforova ◽

Lyudmila Bratchenko ◽

Alexander Moryatov ◽

Sergey Kozlov ◽

...

Keyword(s):

Malignant Melanoma ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Near Infrared ◽

Laser Excitation ◽

Low Cost ◽

Amelanotic Melanoma ◽

Optical Biopsy ◽

Tumor Type

In this work, Raman and autofluorescence spectroscopy in the near-infrared region has been used for examining amelanotic melanoma as the most dangerous type of malignant melanoma. There were 9 patients with amelanotic melanoma, 60 with pigmented melanoma and 120 with basal cell carcinoma enrolled in this study. We studied 9 amelanotic melanoma cases to differentiate them from basal cell carcinoma (n = 120) and pigmented malignant melanoma (n = 60) using portable spectroscopy setup with laser excitation source at 785 nm and low-cost spectrometer. The spectra of the different tumor type were classified using projection on the latent structure analysis with 10-Fold cross-validation. The results of the tumor classification were presented using box-plot diagrams and ROC analysis. We obtained 0.53 and 0.88 ROC AUCs for distinguishing amelanotic melanoma versus (1) pigmented melanoma and (2) basal cell carcinoma respectively based on the joint autofluorescence and Raman spectroscopy analysis that allowed one to diagnose amelanotic melanoma as true melanoma but no basal cell carcinoma.

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Ki-67 and p53 expression in basal cell carcinoma

Journal of Dermatological Science ◽

10.1016/s0923-1811(98)83698-0 ◽

1998 ◽

Vol 16 ◽

pp. S117

Author(s):

Zita Battyáni ◽

Erzsébet Zombai ◽

György Szekeres

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Ki 67 ◽

P53 Expression

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Immunohistochemical evaluation of proliferative activity (Ki-67 index) in different histological types of cutaneous basal cell carcinoma

Biologia ◽

10.2478/s11756-012-0035-8 ◽

2012 ◽

Vol 67 (3) ◽

Cited By ~ 1

Author(s):

Vladimír Bartoš ◽

Katarína Adamicová ◽

Milada Kullová ◽

Martin Péč

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Proliferative Activity ◽

Prognostic Significance ◽

Biological Behavior ◽

Ki 67 ◽

Primary Tumors ◽

Histological Types ◽

Proliferation Activity

AbstractEvaluation of tumor cell proliferation status belongs to the basic prognostic indicators in a routine biopsy report. In cutaneous basal cell carcinoma (BCC), however, there are discrepancies about a true prognostic significance of this histopathological parameter. The aim of this study was to assess a proliferative activity (Ki-67 index) in BCCs of the skin. Biopsy specimens from 80 cutaneous BCCs (63 primary, 17 recurrent) of different histological types from 75 subjects (34 men, 41 women) were enrolled into this study. All samples were immunohistochemically stained by antibody against Ki-67 antigen (DAKO, clone MIB-1, dilution 1:100). For the statistical analysis, χ 2 test was employed. We found a striking percentage variability of nuclear Ki-67 expression in individual tumors (range 2–70%). Mean value of Ki-67 index was 27.4% (in primary tumors 28.1 %, in recurrent lesions 25.6%). The highest Ki-67 expression occurred in infiltrative BCCs (average 38.1%), morpheaform BCCs (average 37.0%), and superficial BCCs (average 35.7%), the lowest expression was recorded in nodular BCCs (average 21.7%) and BCCs with adnexal (trichoepithelial) differentiation (18.6%). There were not persuasive and statistically significant quantitative differences in proliferation activity of tumor cells between the individual histological BCC types, as well as between primary and recurrent lesions. A distribution of Ki-67 positive cells in tumor nests was mostly irregular and areas with a high number of Ki-67 labeled cells often occurred adjacent to areas with a lower number of cells expressing this marker. Because of a marked Ki-67 staining variability, we can conclude that the simple quantification of BCC proliferation activity alone may not be sufficient for the prediction of further biological behavior, evolution and clinical outcome of this malignancy.

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