scholarly journals Heterocyclic compounds based on 3-(4-bromophenyl) azo-5-phenyl-2(3H)-furanone: Anti-avian influenza virus (H5N1) activity / Heterociklički derivati 3-(4-bromfenil) azo-5-fenil-2(3H)-furanona: Djelovanje na virus ptičje gripe (H5N1)

2012 ◽  
Vol 62 (4) ◽  
pp. 593-606 ◽  
Author(s):  
Eman M. Flefel ◽  
Randa E. Abdel-Mageid ◽  
Waled A. Tantawy ◽  
Mohamed A. Ali ◽  
Abd El-Galil E. Amr
Keyword(s):  
Influenza Virus ◽  
Antiviral Activity ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Heterocyclic Compounds ◽  
Madin Darby Canine Kidney ◽  
Plaque Reduction Assay ◽  
Avian Influenza Virus H5n1 ◽  
Darby Canine Kidney

1 3-[2-(4-Bromphenyl)hydrazono]-5-phenyl-furan-2(3H)-one () was used for preparation of some novel pyrazole, pyridazinone, oxadiazole, triazole, thiazolidine and thioxopyrimidine derivatives. Some of the prepared products were tested for anti-avian influenza virus activity and revealed promising antiviral activity against H5N1 virus [A/Chicken/Egypt/1/20 % (H5N1)] by determination of both EC50 and LD50 and confirmed by plaque reduction assay on Madin-Darby canine kidney cells. Compounds 3-[2-(4-bromophenyl)hydrazono]-5-phenylfuran-2(3H)-one (1), 1-(4-bromophenyl)-N-hydroxy-5-phenyl-1H-pyrazole-3-carboxamide (5) and 1-(4-bromophenyl)-N-{2,3-dihydro-4-hydroxy-3-phenyl-6-oxo-2-thioxopyrimidin-1(6H)-yl}-5-phenyl-1H-pyrazole-3-carboxamide (12a) showed the highest effects. Detailed synthesis, spectroscopic data, and antiviral activity of the synthesized compounds are reported.

scholarly journals APOPTOSIS STUDY OF INDONESIAN AVIAN INFLUENZA VIRUS SUBTYPE H5N1 IN MADIN-DARBY CANINE KIDNEY CELLS

2017 ◽  
Vol 11 (1) ◽  
pp. 39-44
Author(s):  
NLP Indi Dharmayanti ◽  
Dwi Rillah Ukhti ◽  
Farida Syamsiah ◽  
Risza Hartawan
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Mdck Cells ◽  
Madin Darby Canine Kidney ◽  
Dna Ladder ◽  
Pathogenic Avian Influenza Virus ◽  
Virus Subtype ◽  
Darby Canine Kidney ◽  
Canine Kidney

This study aimed to determine the ability of highly pathogenic avian influenza virus (HPAI) virus subtype H5N1 originated from Indonesia to induce apoptosis in Madin-Darby Canine Kidney (MDCK) cells. Three HPAI virus subtype H5N1 isolates with different genetic characteristic namely A/Bird/Bali1/2011, A/Chicken/East Java/BwiI2/2010 and A/Chicken/West Java/1074/2003, were cultured in MDCK cells. Apoptosis was identified by deoxyribonucleic acid (DNA) fragmentation of infected MDCK cells using Apoptotic DNA Ladder Kit. The results showed that all three HPAI virus isolates used in this study did not able to induce apoptosis in the MDCK cells within 5 to 72 hours post infection.

scholarly journals DNA probe modified with 3-iron bis(dicarbollide) for electrochemical determination of DNA sequence of Avian Influenza Virus H5N1

2014 ◽  
Vol 51 ◽  
pp. 170-176 ◽  
Author(s):  
Iwona Grabowska ◽  
Anna Stachyra ◽  
Anna Góra-Sochacka ◽  
Agnieszka Sirko ◽  
Agnieszka B. Olejniczak ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Dna Sequence ◽  
Electrochemical Determination ◽  
Dna Probe ◽  
Virus H5n1 ◽  
Avian Influenza Virus H5n1

scholarly journals Experimental Infection and Natural Contact Exposure of Dogs with Avian Influenza Virus (H5N1)

2008 ◽  
Vol 14 (2) ◽  
pp. 308-310 ◽  
Author(s):  
Matthias Giese ◽  
Timm C. Harder ◽  
Jens P. Teifke ◽  
Robert Klopfleisch ◽  
Angele Breithaupt ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Experimental Infection ◽  
Virus H5n1 ◽  
Avian Influenza Virus H5n1 ◽  
Contact Exposure
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