scholarly journals Microstructure, Mechanical Properties, In Vitro Degradation and Cytotoxicity of Mg-4Zn-3HA Alloy for Biodegradable Implant Materials

2014 ◽  
Vol 23 (1) ◽  
pp. 111-118
Author(s):  
Tingting Yang ◽  
Yuxin Ni ◽  
Jingjie Zhai ◽  
Qi Li ◽  
Ling Zheng ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Biodegradable Implant ◽  
In Vitro Degradation ◽  
Implant Materials

Mechanical properties and in vitro degradation of bioresorbable knitted stents

2002 ◽  
Vol 13 (12) ◽  
pp. 1313-1323 ◽  
Author(s):  
Juha-Pekka Nuutinen ◽  
Tero Välimaa ◽  
Claude Clerc ◽  
Pertti Törmälä
Keyword(s):  
Mechanical Properties ◽  
In Vitro Degradation

scholarly journals In vitro and in vivo assessment of biomedical Mg–Ca alloys for bone implant applications

2018 ◽  
Vol 16 (3) ◽  
pp. 126-136 ◽  
Author(s):  
Preeti Makkar ◽  
Swapan Kumar Sarkar ◽  
Andrew R. Padalhin ◽  
Byoung-Gi Moon ◽  
Young Seon Lee ◽  
...  
Keyword(s):  
Corrosion Resistance ◽  
Bone Formation ◽  
Femoral Condyle ◽  
Immersion Test ◽  
Hydrogen Gas ◽  
In Vivo Studies ◽  
Biodegradable Implant ◽  
In Vitro Degradation

Background: Magnesium (Mg)-based alloys are considered to be promising materials for implant application due to their excellent biocompatibility, biodegradability, and mechanical properties close to bone. However, low corrosion resistance and fast degradation are limiting their application. Mg–Ca alloys have huge potential owing to a similar density to bone, good corrosion resistance, and as Mg is essential for Ca incorporation into bone. The objective of the present work is to determine the in vitro degradation and in vivo performance of binary Mg– xCa alloy ( x = 0.5 or 5.0 wt%) to assess its usability for degradable implant applications. Methods: Microstructural evolutions for Mg– xCa alloys were characterized by optical, SEM, EDX, and XRD. In vitro degradation tests were conducted via immersion test in phosphate buffer saline solution. In vivo performance in terms of interface, biocompatibility, and biodegradability of Mg– xCa alloys was examined by implanting samples into rabbit femoral condyle for 2 and 4 weeks. Results: Microstructural results showed the enhancement in intermetallic Mg2Ca phase with increase in Ca content. Immersion tests revealed that the dissolution rate varies linearly, with Ca content exhibiting more hydrogen gas evolution, increased pH, and higher degradation for Mg–5.0Ca alloy. In vivo studies showed good biocompatibility with enhanced bone formation for Mg–0.5Ca after 4 weeks of implantation compared with Mg–5.0Ca alloy. Higher initial corrosion rate with prolonged inflammation and rapid degradation was noticed in Mg–5.0Ca compared with Mg–0.5Ca alloy. Conclusions: The results suggest that Mg–0.5Ca alloy could be used as a temporary biodegradable implant material for clinical applications owing to its controlled in vivo degradation, reduced inflammation, and high bone-formation capability.

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