scholarly journals Mechanical characterization of deep vein thrombosis in a murine model using nanoindentation

2009 ◽  
Author(s):  
K. C. McGilvray ◽  
R. Sarkar ◽  
C. M. Puttlitz
Keyword(s):  
Deep Vein Thrombosis ◽  
Murine Model ◽  
Mechanical Characterization ◽  
Vein Thrombosis ◽  
Deep Vein

A murine model of deep vein thrombosis Characterization and validation in transgenic mice

2005 ◽  
Vol 94 (09) ◽  
pp. 498-503 ◽  
Author(s):  
Linda Szema ◽  
Chao-Ying Chen ◽  
Jeffrey P. Schwab ◽  
Gregory Schmeling ◽  
Brian C. Cooley
Keyword(s):  
Deep Vein Thrombosis ◽  
Murine Model ◽  
Femoral Vein ◽  
Previous History ◽  
Bed Rest ◽  
Major Surgery ◽  
Vein Thrombosis ◽  
Transgenic Lines ◽  
History Of ◽  
Deep Vein

SummaryDeep vein thrombosis (DVT) occurs with high prevalence in association with a number of risk factors, including major surgery, trauma, obesity, bed rest (>5 days), cancer, a previous history of DVT, and several predisposing prothrombotic mutations. A novel murine model of DVT was developed for applications to preclinical studies of transgenically constructed prothrombotic lines and evaluation of new antithrombotic therapies. A transient direct-current electrical injury was induced in the common femoral vein of adult C57Bl/6 mice. A non-occlusive thrombus grew, peaking in size at 30 min, and regressing by 60 min, as revealed by histomorphometric volume reconstruction of the clot. Pre-heparinization greatly reduced clot formation at 10, 30, and 60 min (p<0.01 versus non-heparinized). Homozygous FactorV Leiden mice (analogous to the clinical FactorV Leiden prothrombotic mutation) on a C57Bl/6 background had clot volumes more than twice those of wild-types at 30 min (0.121±0.018 mm3 vs. 0.052±0.008 mm3, respectively; p<0.01). Scanning electron microscopy revealed a clot surface dominated by fibrin strands, in contrast to arterial thrombi which showed a platelet-dominated structure. This new model of DVT presents a quantifiable approach for evaluating thrombosis-related murine transgenic lines and for comparatively evaluating new pharmacologic approaches for prevention of DVT.

The incidence and characterization of deep vein thrombosis following ultrasound-guided foam sclerotherapy in 1000 legs with superficial venous reflux

2013 ◽  
Vol 1 (3) ◽  
pp. 231-238 ◽  
Author(s):  
Sachin R. Kulkarni ◽  
David E. Messenger ◽  
Fiona J.A. Slim ◽  
Lorraine G. Emerson ◽  
Richard A. Bulbulia ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Venous Reflux ◽  
Ultrasound Guided ◽  
Foam Sclerotherapy ◽  
Vein Thrombosis ◽  
Deep Vein

3D T 1-mapping for the characterization of deep vein thrombosis

2009 ◽  
Vol 22 (6) ◽  
pp. 375-383 ◽  
Author(s):  
Ulrike Blume ◽  
James Orbell ◽  
Matthew Waltham ◽  
Alberto Smith ◽  
Reza Razavi ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Vein Thrombosis ◽  
Deep Vein

684 Risk for Deep Vein Thrombosis and Pulmonary Embolism after Heart Transplantation: Characterization of an Old Problem

2012 ◽  
Vol 31 (4) ◽  
pp. S235
Author(s):  
J. Moriguchi ◽  
J. Patel ◽  
M. Kittleson ◽  
M. Rafiei ◽  
L. Stern ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Deep Vein Thrombosis ◽  
Heart Transplantation ◽  
Vein Thrombosis ◽  
Deep Vein

scholarly journals RISK FOR DEEP VEIN THROMBOSIS AND PULMONARY EMBOLISM AFTER HEART TRANSPLANTATION: CHARACTERIZATION OF AN OLD PROBLEM

2012 ◽  
Vol 59 (13) ◽  
pp. E922
Author(s):  
Wanxing Chai ◽  
Jignesh Patel ◽  
Michelle Kittleson ◽  
Lawrence Czer ◽  
Matthew Rafiei ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Deep Vein Thrombosis ◽  
Heart Transplantation ◽  
Vein Thrombosis ◽  
Deep Vein

scholarly journals Multi-sequence non-contrast MRI characterization of deep vein thrombosis in man

2015 ◽  
Vol 17 (S1) ◽  
Author(s):  
Alkystis Phinikaridou ◽  
Prakash Saha ◽  
Marcelo E Andia ◽  
Alberto Smith ◽  
Rene Botnar
Keyword(s):  
Deep Vein Thrombosis ◽  
Vein Thrombosis ◽  
Deep Vein
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