scholarly journals Perihemorrhagic edema in non-traumatic intracerebral hematomas

2018 ◽  
Vol 0 (3) ◽  
pp. 5-14
Author(s):  
Yuris L. Dzenis ◽  
Aivars Yu. Olmanis
Keyword(s):  
Perihemorrhagic Edema

Intracerebral Hematoma, Perihemorrhagic Edema and Urinary Excreted Cysteinyl Leukotrienes Correlation Study

2014 ◽  
Vol 68 (2) ◽  
pp. 85-88
Author(s):  
Natalija Dolnenec-Baneva ◽  
Dijana Nikodijevic ◽  
Gordana Kiteva-Trenchevska ◽  
Igor Petrov ◽  
Dragana Petrovska-Cvetkovska ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Brain Edema ◽  
Correlation Study ◽  
Intracerebral Hematoma ◽  
Moderate Correlation ◽  
Hematoma Volume ◽  
Cysteinyl Leukotrienes ◽  
Edema Volume ◽  
Perihemorrhagic Edema

AbstractIntroduction.Several mechanisms in formation of perihemorrhagic edema are activated after contact of brain tissue-extravasated blood in intracerebral hemorrhage. Cysteinyl leukotrienes (cysLT) (C4, D4, E4) are included in this process as significant edema factors and they determine the neurological deficit and outcome. The study aim was a 5-day follow-up (admission/3 day/5 day) of urinary cysLT, hematoma volume, edema volume values and their correlation in patients after spontaneous, primary supratentorial intracerebral hemorrhage.Methods.An enzyme immunoassay was used for urinary cysLT measured in 62 patients and 80 healthy controls. Hematoma and edema volumes were visualized and measured by computed tomography and mathematically calculated with a special spheroid shape formula (V=AxBxC/2).Results.CysLT of hemorrhagic patients (1842.20±1413.2, 1181.54±906.2, 982.30±774.2pg/ml/mg creatinine) were significantly excreted (p<0.01). Brain edema (12.86±13.5, 22.38±21.1, 28.45±29.4cm3) was significantly increased (p<0.01). Hematoma volume values (13.05±14.5, 13.13±14.7, 12.99±14.7cm3) were not significant (p>0.05). A high correlation (multiple regression) between cysLT, hematoma and edema was found on the 3rdday (R=0.6) and a moderate correlation at admission (R=0.3) and on the 5thday (R=0.3).Conclusion.In our 5-day follow-up study a significant cysLT brain synthesis and significant brain edema progression versus constant hematoma volume values in hemorrhagic patients was found. A high correlation between cysLT, hematoma and edema volume was found on the 3rdday, a moderate correlation on admission and on the 5thday, which means that high cysLT and hematoma values were associated with high/moderate edema values.

scholarly journals Siponimod (BAF-312) Attenuates Perihemorrhagic Edema And Improves Survival in Experimental Intracerebral Hemorrhage

Stroke ◽  
2019 ◽  
Vol 50 (11) ◽  
pp. 3246-3254 ◽  
Author(s):  
Tobias Bobinger ◽  
Anatol Manaenko ◽  
Petra Burkardt ◽  
Vanessa Beuscher ◽  
Maximilian I. Sprügel ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Perihemorrhagic Edema

scholarly journals Impact of Hypothermia Initiation and Duration on Perihemorrhagic Edema Evolution After Intracerebral Hemorrhage

Stroke ◽  
2016 ◽  
Vol 47 (9) ◽  
pp. 2249-2255 ◽  
Author(s):  
Bastian Volbers ◽  
Sabrina Herrmann ◽  
Wolfgang Willfarth ◽  
Hannes Lücking ◽  
Stephan P. Kloska ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Perihemorrhagic Edema

Semi-automatic volumetric assessment of perihemorrhagic edema with computed tomography

2011 ◽  
Vol 18 (11) ◽  
pp. 1323-1328 ◽  
Author(s):  
Bastian Volbers ◽  
Dimitre Staykov ◽  
Ingrid Wagner ◽  
Arnd Dörfler ◽  
Marc Saake ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Volumetric Assessment ◽  
Perihemorrhagic Edema

scholarly journals Hypothermia Reduces Perihemorrhagic Edema After Intracerebral Hemorrhage

Stroke ◽  
2010 ◽  
Vol 41 (8) ◽  
pp. 1684-1689 ◽  
Author(s):  
Rainer Kollmar ◽  
Dimitre Staykov ◽  
Arnd Dörfler ◽  
Peter D. Schellinger ◽  
Stefan Schwab ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Perihemorrhagic Edema

scholarly journals Intraventricular Fibrinolysis Does Not Increase Perihemorrhagic Edema After Intracerebral Hemorrhage

Stroke ◽  
2013 ◽  
Vol 44 (2) ◽  
pp. 362-366 ◽  
Author(s):  
Bastian Volbers ◽  
Ingrid Wagner ◽  
Wolfgang Willfarth ◽  
Arnd Doerfler ◽  
Stefan Schwab ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Intraventricular Fibrinolysis ◽  
Perihemorrhagic Edema

Abstract WP351: No Effect of Mannitol on the Course of Perihemorrhagic Edema After Intracerebral Hemorrhage

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Bastian Volbers ◽  
Sabrina Herrmann ◽  
Wolfgang Willfarth ◽  
Hagen B Huttner ◽  
Stefan Lang ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Clinical Data ◽  
Clinical Status ◽  
Bolus Administration ◽  
Predictive Role ◽  
Intraventricular Bleeding ◽  
Basic Characteristics ◽  
Underlying Mechanisms ◽  
Perihemorrhagic Edema ◽  
Osmotic Agents

Introduction: In patients with intracerebral hemorrhage (ICH) perihemorrhagic edema (PHE) seems to play a predictive role besides initial hematoma size, clinical status and intraventricular bleeding (IVH). PHE may exceed the initial hematoma volume by up to 600% thereby leading to increased intracranial pressure (ICP) which may cause severe clinical deterioration. EUSI and ASA guidelines recommend the use of intravenous mannitol or hypertonic saline (HS) in order to reduce elevated ICP. However, clinical data suggest that HS may be superior to mannitol in lowering ICP and clinical data concerning the effect of mannitol on PHE as a cause of elevated ICP is limited. We aimed to investigate the effect of mannitol on PHE after ICH. Methods: Patients with supratentorial spontaneous ICH treated with 20% intravenous mannitol solution (125-250ml every 6h) for 5-10 days and controls matched for ICH volume, age and IVH who did not receive any osmotic agents during the course of treatment were identified retrospectively from our institutional ICH database. PHE volume was calculated on diagnostic CT scans performed on days 1, 2-3, 4-6, 7-9 and 10-12 using a validated volumetric algorithm. Frequency of elevated ICP up to day 12 (ICP burden), modified Rankin Scale (mRS) after rehabilitation (approx. day 90) and PHE evolution were assessed as outcome variables. Results: 44 ICH patients treated with mannitol and 43 controls were included. Basic characteristics did not differ between groups (median ICH volume day 1: 32.9 mL (IQR 16.3 - 54.0) and 27.7 mL (IQR 22.4 - 37.1), p=0.786; median age 71 y (IQR 61.5 - 77) and 72 y (IQR 66 - 81), p=0.269; median PHE volume day 1: 24.3 mL (IQR 16.0 - 38.8) and 24.3 mL (IQR 17.1 - 32.1), p=0.592, respectively). In the mannitol group PHE volume exceeded to a greater extent than in controls (PHE on day 10-12: 60.1 mL (SD 33.6) vs. 36.8 mL (SD 23.2), p=0.005). Median ICP burden was higher in the mannitol group (0 (IQR 0 - 7.75) vs. 0 (IQR 0), p=0.016). Median mRS did not differ between both groups (4 (IQR 4-6) vs. 4 (IQR 3-6), p=0.321). Conclusions: We found no effect of mannitol use on the general evolution of PHE and ICP. Other underlying mechanisms may explain the short-term effect of mannitol bolus administration on ICP in patients with spontaneous supratentorial ICH.

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