ENDOMETRIAL HYPERPLASIA AND CANCER IN YOUNG WOMEN: A NATIONAL STUDY OF PATTERNS OF CARE AND PREGANCY OUTCOMES

2016 ◽  
Author(s):  
Larissa Meyer
Keyword(s):  
Young Women ◽  
Endometrial Hyperplasia ◽  
Patterns Of Care ◽  
National Study

Conservative therapy for adenocarcinoma and atypical endometrial hyperplasia of the endometrium in young women: central pathologic review and treatment outcome

2001 ◽  
Vol 167 (1) ◽  
pp. 39-48 ◽  
Author(s):  
Tsunehisa Kaku ◽  
Hiroyuki Yoshikawa ◽  
Hitoshi Tsuda ◽  
Atsuhiko Sakamoto ◽  
Masaharu Fukunaga ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Young Women ◽  
Endometrial Hyperplasia ◽  
Conservative Therapy ◽  
Atypical Endometrial Hyperplasia

Is Age a Risk Factor for Endometrial Hyperplasia or Cancer in Young Women With Abnormal Bleeding? [49]

2015 ◽  
Vol 125 ◽  
pp. 24S-25S
Author(s):  
Jeong Hyun Kim ◽  
Cecilia Karin Wieslander ◽  
Christine H. Holschneider ◽  
Catherine M. Crespi
Keyword(s):  
Risk Factor ◽  
Young Women ◽  
Endometrial Hyperplasia ◽  
Abnormal Bleeding

scholarly journals 128P Characteristics, patterns of care and outcomes of young women with breast cancer (BC) according to age, year of diagnosis and germline BRCA status (gBRCA)

2021 ◽  
Vol 32 ◽  
pp. S413-S414
Author(s):  
K. Punie ◽  
M.A. Franzoi ◽  
B. Dullens ◽  
A. Laenen ◽  
C. Fernandes Costa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Young Women ◽  
Patterns Of Care

Testosterone and 17β-oestradiol secretion of the human ovary. I. Normal young women, and premenopausal women with endometrial hyperplasia

Maturitas ◽  
1980 ◽  
Vol 2 (1) ◽  
pp. 1-5 ◽  
Author(s):  
J. Botella-Llusiá ◽  
A. Oriol-Bosch ◽  
F. Sánchez-Garrido ◽  
J.A.F. Tresguerres
Keyword(s):  
Young Women ◽  
Endometrial Hyperplasia ◽  
Premenopausal Women ◽  
Human Ovary

Letrozole as primary therapy for endometrial hyperplasia in young women

2007 ◽  
Vol 100 (1) ◽  
pp. 10-12 ◽  
Author(s):  
Hongzhen Li ◽  
Xinna Chen ◽  
Jie Qiao
Keyword(s):  
Young Women ◽  
Endometrial Hyperplasia ◽  
Primary Therapy

ENDOMETRIAL HYPERPLASIA IN YOUNG WOMEN

1971 ◽  
Vol 26 (5) ◽  
pp. 387-388
Author(s):  
DIKRAN L. CHAMLIAN ◽  
HERBERT B. TAYLOR
Keyword(s):  
Young Women ◽  
Endometrial Hyperplasia

Fertility-Sparing Treatment of Early Endometrial Cancer and Complex Atypical Hyperplasia in Young Women of Childbearing Potential

2015 ◽  
Vol 25 (6) ◽  
pp. 1010-1014 ◽  
Author(s):  
Stanislav Mikhailovich Pronin ◽  
Olga Valerievna Novikova ◽  
Julia Yurievna Andreeva ◽  
Elena Grigorievna Novikova
Keyword(s):  
Endometrial Cancer ◽  
Young Women ◽  
Hormonal Therapy ◽  
Endometrial Hyperplasia ◽  
Endometrial Adenocarcinoma ◽  
Gonadotropin Releasing Hormone ◽  
Atypical Hyperplasia ◽  
Childbearing Potential ◽  
Atypical Endometrial Hyperplasia ◽  
Gonadotropin Releasing Hormone Agonist

ObjectiveTo evaluate oncologic and reproductive outcome with levonorgestrel-releasing intrauterine system combined with gonadotropin-releasing hormone agonist in women with grade 1 endometrial carcinoma, and the levonorgestrel monotherapy in women with complex atypical hyperplasia.Materials/MethodsA prospective study was conducted. We analyzed the clinical characteristics of 70 patients younger than 42 years (mean age, 33 years) with a diagnosis of complex atypical endometrial hyperplasia (AEH) or grade 1 endometrial adenocarcinoma who were treated with hormonal therapy at the Division of Gynecologic Oncology of P.A. Hertsen Moscow Cancer Research Institute from February 2009 to December 2012. Patients with complex AEH received monotherapy with levonorgestrel-releasing intrauterine system (Mirena, Shering, Finland; 52 mg). Patients with a diagnosis of grade 1 endometrial cancer were treated with levonorgestrel-releasing intrauterine system combined with gonadotropin-releasing hormone agonist (Zoladex; AstraZeneca UK Limited, UK; 3.6-mg depot). All the patients received hormonal therapy for a minimum of 6 months. Pretreatment evaluation consisted of transabdominal and transvaginal ultrasound in grayscale, color Doppler ultrasound, contrast-enhanced magnetic resonance imaging,cervical hysteroscopy, Pipelle endometrial biopsy, and morphological and immunohistochemical characteristics of the tissue.ResultsSeventy patients were included in study analyses. Twenty three (72%) of 32 patients with adenocarcinoma and 35 (92%) of 38 patients with AEH had complete remission, defined as the absence of any carcinoma or hyperplasia on endometrial sampling specimens. Among these cases, 2 patients with adenocarcinoma and 1 patient with AEH had recurrence after their complete response. Nine patients had persistent disease. Eight patients had 10 conceptions, resulting in 8 live births.ConclusionsThe suggested conservative treatment strategy can be considered as a valid therapeutic option for young women of childbearing potential with atypical endometrial hyperplasia and grade 1 endometrial adenocarcinoma who wish to preserve their fertility and thus may be recommended as an alternative to hysterectomy. Close follow-up during and after the treatment period is strictly required.

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