Symptoms of early stage endometrial cancer recurrence – related to routine follow-up

2016 ◽  
Author(s):  
Mette Moustgaard Jeppesen
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Cancer Recurrence ◽  
Early Stage Endometrial Cancer

Why Routine Clinical Follow-up for Patients With Early-Stage Endometrial Cancer Is Not Always Necessary

2014 ◽  
Vol 69 (8) ◽  
pp. 470-471
Author(s):  
Lilly Aung ◽  
Robert E. J. Howells ◽  
Kenneth C. K. Lim ◽  
Emma Hudson ◽  
Peter W. Jones
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Early Stage Endometrial Cancer

Laparoscopic Versus Laparotomic Approach for Early Stage Endometrial Cancer: A Long-Term Follow-Up Study

2008 ◽  
Vol 15 (6) ◽  
pp. 42S-43S
Author(s):  
S. Palomba ◽  
A. Falbo ◽  
T. Russo ◽  
R. Oppedisano ◽  
R. Mocciaro ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Follow Up Study ◽  
Long Term Follow Up ◽  
Early Stage Endometrial Cancer

Definitive radiotherapy for vaginal recurrence of early-stage endometrial cancer: survival outcomes and effect of mismatch repair status

2021 ◽  
pp. ijgc-2021-002536
Author(s):  
Gabriela Alban ◽  
Teresa Cheng ◽  
Jenna Adleman ◽  
Ivan Buzurovic ◽  
Jennifer Pretz ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Mismatch Repair ◽  
Early Stage ◽  
Recurrence Free Survival ◽  
Free Survival ◽  
Definitive Radiotherapy ◽  
Image Guided ◽  
Early Stage Endometrial Cancer ◽  
Vaginal Recurrence

ObjectiveTo evaluate clinical outcomes, prognostic factors, and toxicity in patients with vaginal recurrence of early-stage endometrial cancer treated with definitive radiotherapy.MethodsRetrospective review identified 62 patients with stage I–II endometrial cancer and vaginal recurrence treated with external beam radiotherapy and image-guided brachytherapy with definitive intent from November 2004 to July 2017. All patients had prior hysterectomy without adjuvant radiotherapy and >3 months follow-up. Mismatch repair (MMR) status was determined by immunohistochemical staining of the four mismatch repair proteins (MLH1, MSH2, PMS2, and MSH6) when available in the pathology record. Rates of vaginal control, recurrence-free survival, and overall survival were calculated by Kaplan–Meier. Univariate and multivariate analyses were performed by Cox proportional hazards.ResultsMost patients had endometrioid histology (55, 89%), grade 1 or 2 tumor (53, 85%), and vaginal-only recurrence (55, 89%). With a median follow-up of 39 months (range, 3–167), 3- and 5-year rates of vaginal control, recurrence-free survival, and overall survival were 86% and 82%, 69% and 55%, and 80% and 61%, respectively. On multivariate analysis, non-endometrioid histology (HR 12.5, P<0.01) was associated with relapse when adjusted for chemotherapy use. Patients with non-endometrioid histology also had a 4.5-fold higher risk of death when adjusted for age (P=0.02). Twenty patients had known MMR status, all with grade 1–2 endometrioid tumors and 10 (50%) with MMR deficiency. The 3-year recurrence-free survival was 100% for MMR-proficient tumors and 52% for MMR-deficient (P=0.03). Late grade 2 and 3 gastrointestinal, genitourinary and vaginal toxicity was reported in 27% and 3%, 15% and 2%, and 16% and 2% of patients, respectively.ConclusionDefinitive radiotherapy with image-guided brachytherapy resulted in 5-year local control rates exceeding 80% and late severe toxicity rates were under 3%. Distant recurrence was common and highest for those with grade 3 or non-endometrioid tumors and MMR deficient grade 1–2 disease.

Authors’ reply re: Patient-initiated follow-up affects fear of recurrence and health care use: a randomised trial in early-stage endometrial cancer

2018 ◽  
Vol 125 (13) ◽  
pp. 1778-1779 ◽  
Author(s):  
Mette Moustgaard Jeppesen ◽  
Pernille Tine Jensen ◽  
Dorte Gilså Hansen ◽  
René dePont Christensen ◽  
Ole Mogensen
Keyword(s):  
Health Care ◽  
Endometrial Cancer ◽  
Early Stage ◽  
Randomised Trial ◽  
Health Care Use ◽  
Fear Of Recurrence ◽  
Early Stage Endometrial Cancer

Preoperative work-up for definition of lymph node risk involvement in early stage endometrial cancer: 5-year follow-up

2017 ◽  
Vol 69 (1) ◽  
pp. 75-82 ◽  
Author(s):  
Pietro Cignini ◽  
Salvatore Giovanni Vitale ◽  
Antonio Simone Laganà ◽  
Antonio Biondi ◽  
Valentina Lucia La Rosa ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Early Stage ◽  
Definition Of ◽  
Preoperative Work Up ◽  
Work Up ◽  
Early Stage Endometrial Cancer
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