Transdermal Delivery of Human Growth Hormone via Laser-Generated Micropores

2016 ◽  
Author(s):  
Yang Song
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Transdermal Delivery ◽  
Human Growth

Lecithin soybean phospholipid nano‐transfersomes as potential carriers for transdermal delivery of the human growth hormone

2018 ◽  
Vol 120 (6) ◽  
pp. 9023-9033 ◽  
Author(s):  
Maryam Kateh Shamshiri ◽  
Amir Abbas Momtazi‐Borojeni ◽  
Mahvash Khodabandeh Shahraky ◽  
Fatemeh Rahimi
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Transdermal Delivery ◽  
Human Growth ◽  
Soybean Phospholipid

Transdermal delivery of human growth hormone via laser-generated micropores

2017 ◽  
Vol 8 (2) ◽  
pp. 450-460 ◽  
Author(s):  
Yang Song ◽  
Karishma Hemmady ◽  
Ashana Puri ◽  
Ajay K. Banga
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Transdermal Delivery ◽  
Human Growth

Transdermal Delivery of Human Growth Hormone Through RF-Microchannels

2005 ◽  
Vol 22 (4) ◽  
pp. 550-555 ◽  
Author(s):  
Galit Levin ◽  
Amikam Gershonowitz ◽  
Hagit Sacks ◽  
Meir Stern ◽  
Amir Sherman ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Transdermal Delivery ◽  
Human Growth

scholarly journals Dissolving Microneedle Patch for Transdermal Delivery of Human Growth Hormone

Small ◽  
2011 ◽  
Vol 7 (4) ◽  
pp. 531-539 ◽  
Author(s):  
Jeong Woo Lee ◽  
Seong-O Choi ◽  
Eric I. Felner ◽  
Mark R. Prausnitz
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Transdermal Delivery ◽  
Human Growth ◽  
Microneedle Patch

Transdermal delivery of hyaluronic acid – Human growth hormone conjugate

Biomaterials ◽  
2012 ◽  
Vol 33 (25) ◽  
pp. 5947-5954 ◽  
Author(s):  
Jeong-A. Yang ◽  
Eung-Sam Kim ◽  
Jung Hee Kwon ◽  
Hyemin Kim ◽  
Ji Hye Shin ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hyaluronic Acid ◽  
Human Growth Hormone ◽  
Transdermal Delivery ◽  
Human Growth

scholarly journals Iontophoretic Transdermal Delivery of Human Growth Hormone (hGH) and the Combination Effect of a New Type Microneedle, Tappy Tok Tok®

Pharmaceutics ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 153 ◽  
Author(s):  
Gyubin Noh ◽  
Taekwang Keum ◽  
Jo-Eun Seo ◽  
Santosh Bashyal ◽  
Nyeon-Sik Eum ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Current Density ◽  
Transdermal Delivery ◽  
Recombinant Human Growth Hormone ◽  
Skin Barrier ◽  
Human Growth ◽  
Blue Staining ◽  
Citrate Buffer

Transdermal drug administration presents several advantages and it is therefore favorable as an alternative drug delivery route. However, transdermal delivery of biopharmaceutical drugs is made difficult by the skin barrier. Microneedle application and iontophoresis are strategies which can be used to overcome this barrier. Therefore, recombinant human growth hormone (rhGH) was used as a model macromolecular drug and was transdermally delivered using microneedle application and iontophoresis. Methylene blue staining, stereomicroscopy and scanning electron microscope (SEM) imaging were used to characterize the microchannels produced. To optimize the iontophoresis protocol, the effects of molecular charge and current density on transdermal delivery were evaluated in an in vitro permeation study using excised rat skin tissues. Using the optimized iontophoresis protocol, the combination effects of iontophoretic delivery via microchannels were evaluated in three different experimental designs. The flux obtained with anodal iontophoresis in citrate buffer was approximately 10-fold higher that that with cathodal iontophoresis in phosphate buffered saline (PBS). Flux also increased with current density in anodal iontophoresis. The combination of iontophoresis and microneedle application produced higher flux than single application. These results suggest that anodal iontophoresis with higher current density enhances the permeation of macromolecules through microchannels created by microneedles. In conclusion, the combination of iontophoresis and microneedles is a potential strategy for the enhancement of transdermal delivery of macromolecular drugs.

LIPOLYTIC ACTIVITY OF ENZYME DIGESTED HUMAN GROWTH HORMONE

1965 ◽  
Vol 49 (3_Suppl) ◽  
pp. S143
Author(s):  
Zvi Laron ◽  
Avivah Kowadlo-Silbergeld
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Lipolytic Activity ◽  
Human Growth
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