microneedle patch
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2022 ◽  
Vol 23 (1) ◽  
Author(s):  
Ankitha Prabhu ◽  
Jobin Jose ◽  
Lalit Kumar ◽  
S Salwa ◽  
M Vijay Kumar ◽  
...  

2022 ◽  
Vol 34 (1) ◽  
pp. 2270008
Author(s):  
Zijing Wang ◽  
Zhipeng Yang ◽  
Jianjuan Jiang ◽  
Zhifeng Shi ◽  
Ying Mao ◽  
...  

Pharmaceutics ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 5
Author(s):  
Naveed Ur Rehman ◽  
Chanwoo Song ◽  
Junhyeong Kim ◽  
Inhwan Noh ◽  
Yun-Seok Rhee ◽  
...  

Research on the development of dissolving microneedles (DMNs) has focused on bolus drug delivery, with little attention on sustained release. Here, we evaluated the sustained release, absorption pattern, and effective drug permeation of a novel donepezil-loaded DMN patch through an in vivo investigation on rats. The applications of DMN patches to the shaved skin of rats for 1 week and 1 h were compared with oral donepezil administration to assess their sustained release capabilities. We used a validated liquid chromatography–tandem mass spectrometry method to quantify donepezil in the plasma. We found that the microneedle arrays effectively delivered donepezil across the skin, with dissolution observed within 1 h of application. Furthermore, skin irritation test showed that the patches produced no irritation response. The DMN arrays also effectively increased drug permeation and demonstrated sustained release and absorption of donepezil from DMN patches. These patches allow extended dosing intervals, reduced gastrointestinal adverse effects, and convenient self-administration to mitigate poor drug compliance, making them beneficial for the treatment of elderly patients with Alzheimer’s disease.


Vaccines ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1480
Author(s):  
Sachiko Hirobe ◽  
Takuto Kawakita ◽  
Taki Yamasaki ◽  
Sayami Ito ◽  
Masashi Tachibana ◽  
...  

In this study, we investigated the mechanism of transcutaneous adjuvant activity of the CpG-oligonucleotide (K3) in mice. Transcutaneous immunization (TCI) with an ovalbumin-loaded self-dissolving microneedle patch (OVA-sdMN) and K3-loaded hydrophilic gel patch (HG) increased OVA-specific Th2- and Th1-type IgG subclass antibody titers more rapidly and strongly than those after only OVA-sdMN administration. However, the antigen-specific proliferation of OVA-specific CD4+ T cells was similar between the OVA-only and the OVA+K3 groups. Population analysis of various immune cells in draining lymph nodes (dLNs) in the primary immune response revealed that the OVA+K3 combination doubled the number of dLN cells, with the most significant increase in B cells. Phenotypic analysis by flow cytometry revealed that B-cell activation and maturation were promoted in the OVA+K3 group, suggesting that direct B-cell activation by K3 largely contributed to the rapid increase in antigen-specific antibody titer in TCI. In the secondary immune response, a significant increase in effector T cells and effector memory T cells, and an increase in memory B cells were observed in the OVA+K3 group compared with that in the OVA-only group. Thus, K3, as a transcutaneous adjuvant, can promote the memory differentiation of T and B cells.


2021 ◽  
Vol 25 ◽  
pp. 101188
Author(s):  
Can Hong ◽  
Guoliang Zhang ◽  
Wei Zhang ◽  
Jiaqi Liu ◽  
Jiao Zhang ◽  
...  

Matter ◽  
2021 ◽  
Author(s):  
Xuexiang Zhang ◽  
Mohammad Mahdi Hasani-Sadrabadi ◽  
Jana Zarubova ◽  
Erfan Dashtimighadam ◽  
Reihaneh Haghniaz ◽  
...  

ACS Nano ◽  
2021 ◽  
Author(s):  
Mengting Yin ◽  
Jiayingzi Wu ◽  
Mingwu Deng ◽  
Pei Wang ◽  
Guangyu Ji ◽  
...  

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