DETECTION OF VIRUSES AND ROLE OF HUMAN BOCAVIRUS IN CHILDREN WITH LOWER RESPIRATORY TRACT INFECTIONS

2017 ◽  
Author(s):  
Ozden Turel
Keyword(s):  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Human Bocavirus ◽  
Lower Respiratory Tract Infections ◽  
Tract Infections

Lower Respiratory Tract Infection Therapy – the Role of Ciprofloxacin

1995 ◽  
Vol 23 (5) ◽  
pp. 315-327 ◽  
Author(s):  
A P Ball ◽  
G S Tillotson
Keyword(s):  
Respiratory Tract ◽  
Moraxella Catarrhalis ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Lower Respiratory Tract Infections ◽  
Tissue Penetration ◽  
Tract Infections ◽  
Respiratory Tissue ◽  
Unpublished Information

Lower respiratory tract infections account for a large proportion of prescribed antibiotics and, with emerging resistance to standard agents, the introduction of the fluoroquinolones, in particular ciprofloxacin, has provided a further component in the armamentarium. This review encompasses 37 published clinical trials which featured ciprofloxacin; 3274 patients with lower respiratory tract infections were treated with this agent; in 94.1% of patients treatment was clinically successful and 90.9% of cases showed eradication of the causative pathogen. When these data were supplemented with previously unpublished Information from the clinical trial database, specific organism eradication rates of 86.1%, 96.2% and 94.6% for Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis, respectively, were observed. These findings suggest that the high respiratory tissue penetration of ciprofloxacin and the achievable minimum inhibitory concentrations lead to acceptable clinical outcomes in lower respiratory tract infections.

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