HEMOLYTIC ANEMIA WITH INTRAVENOUS IMMUNOGLOBULIN IN IMMUNODEFICIENCY AND IMMUNE THROMBOCYTOPENIA: EFFECT OF ANTI-A DONOR SCREENING

2017 ◽  
Author(s):  
Hubsch Alphonse
Keyword(s):  
Intravenous Immunoglobulin ◽  
Hemolytic Anemia ◽  
Immune Thrombocytopenia ◽  
Donor Screening

scholarly journals NUDT15 polymorphism explains serious toxicity to azathioprine in Indian patients with chronic immune thrombocytopenia and autoimmune hemolytic anemia: a case series

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Anup J. Devasia ◽  
Raveen Stephen Stallon Illangeswaran ◽  
Infencia Xavier Raj ◽  
Biju George ◽  
Poonkuzhali Balasubramanian
Keyword(s):  
Hemolytic Anemia ◽  
Autoimmune Hemolytic Anemia ◽  
Immune Thrombocytopenia ◽  
Case Series ◽  
Severe Toxicity ◽  
Toxic Side Effect ◽  
Case Presentation ◽  
Oral Ulcers ◽  
Asian Patients ◽  
Life Threatening

AbstractObjectivesAzathioprine (AZA) is a commonly used immunosuppressant in patients with autoimmune diseases. The toxic side effect to AZA (myelosuppression, hair loss, and oral ulcers) are highly unpredictable which can be life threatening if not identified earlier and dose adjustments made or the drug is withdrawn.Case presentationHere we report a case series of five patients with severe toxicity while on treatment with AZA for autoimmune hemolytic anemia (n=1) and Immune thrombocytopenia (n=4). The common thiopurine methyltransferase (TPMT) variants (TPMT*2, *3A, *3B) were not present in these patients. However, all these patients had the NUDT15 415C>T variant that has been reported to explain serious toxicity to thioguanine in Asian patients.ConclusionsOur report suggests pre-emptive genotype-based dosing of AZA could reduce adverse toxicity and hence better outcome.

scholarly journals Ceftriaxone-induced hemolytic anemia in a child successfully managed with intravenous immunoglobulin

2016 ◽  
Vol 58 (2) ◽  
pp. 216 ◽  
Author(s):  
Aysel Vehapoğlu ◽  
Nilüfer Göknar ◽  
Rümeysa Tuna ◽  
Fatma Betül Çakır
Keyword(s):  
Intravenous Immunoglobulin ◽  
Hemolytic Anemia

Outcome of national oversight of intravenous immunoglobulin prescribing in immune thrombocytopenia

2020 ◽  
pp. jclinpath-2020-207037
Author(s):  
Siraj A Misbah ◽  
Mike F Murphy ◽  
Sue Pavord ◽  
Quentin Hill ◽  
Rob Coster ◽  
...  
Keyword(s):  
Intravenous Immunoglobulin ◽  
Immune Thrombocytopenia
Sign in / Sign up

Export Citation Format

Share Document