Adolescents at Ultra-high Risk of Psychosis in Italian Neuropsychiatry Services: Prevalence, Psychopathology and Transition Rate

2018 ◽  
Author(s):  
Lorenzo Pelizza
Keyword(s):  
High Risk ◽  
Transition Rate ◽  
Ultra High Risk

scholarly journals Declining Transition Rate in Ultra High Risk (Prodromal) Services: Dilution or Reduction of Risk?

2007 ◽  
Vol 33 (3) ◽  
pp. 673-681 ◽  
Author(s):  
A. R. Yung ◽  
H. P. Yuen ◽  
G. Berger ◽  
S. Francey ◽  
T.-C. Hung ◽  
...  
Keyword(s):  
High Risk ◽  
Transition Rate ◽  
Ultra High Risk

scholarly journals Ultra High Risk Status and Transition to Psychosis in 22q11.2 Deletion Syndrome

2017 ◽  
Vol 41 (S1) ◽  
pp. S81-S82
Author(s):  
M. Armando ◽  
M. Schneider ◽  
M. Pontillo ◽  
S. Vicari ◽  
M. Debbane ◽  
...  
Keyword(s):  
High Risk ◽  
Predictive Value ◽  
Transition Rate ◽  
22Q11.2 Deletion Syndrome ◽  
Human Model ◽  
Deletion Syndrome ◽  
Additional Contribution ◽  
22Q11.2 Deletion ◽  
Level Of Functioning ◽  
Ultra High Risk

The 22q11.2 deletion syndrome (22q11DS) is characterized by high rates of psychotic symptoms and schizophrenia, making this condition a promising human model for studying risk factors for psychosis. We explored the predictive value of ultra high-risk (UHR) criteria in a sample of patients with 22q11DS. We also examined the additional contribution of sociodemographic, clinical and cognitive variables to predict transition to psychosis within a mean interval of 32.56176 months after initial assessment. Eighty-nine participants with 22q11DS (age range: 8–30 years; mean: 16.1647) were assessed using the structured interview for psychosis-risk syndromes. Information on axis I diagnoses, internalizing and externalizing symptoms, level of functioning and IQ was also collected. At baseline, 22 (24.7%) participants met UHR criteria. Compared to those without a UHR condition, they had a significantly lower functioning, more frequent anxiety disorders and more severe psychopathology. Transition rate to psychosis was 27.3% in UHR and 4.5% in non-UHR participants. Cox regression analyses revealed that UHR status significantly predicted conversion to psychosis. Baseline level of functioning was the only other additional predictor. This is the first study investigating the predictive value of UHR criteria in 22q11DS. It indicates that the clinical path leading to psychosis is broadly comparable to that observed in other clinical high-risk samples. Nevertheless, the relatively high transition rate in non-UHR individuals suggests that other risk markers should be explored in this population. The role of low functioning as a predictor of transition to psychosis should also be investigated more in depth.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Adolescents at ultra-high risk of psychosis in Italian neuropsychiatry services: prevalence, psychopathology and transition rate

2017 ◽  
Vol 27 (6) ◽  
pp. 725-737 ◽  
Author(s):  
Lorenzo Pelizza ◽  
Silvia Azzali ◽  
Sara Garlassi ◽  
Federica Paterlini ◽  
Ilaria Scazza ◽  
...  
Keyword(s):  
High Risk ◽  
Transition Rate ◽  
Ultra High Risk

REDUCTION IN TRANSITION RATE IN AN ULTRA-HIGH RISK (‘PRODROMAL’) SERVICE DUE TO EARLIER DETECTION

2008 ◽  
Vol 102 (1-3) ◽  
pp. 157
Author(s):  
Alison Yung ◽  
Hok Pan Yuen ◽  
Gregor Berger ◽  
Shona Francey ◽  
Barnaby Nelson ◽  
...  
Keyword(s):  
High Risk ◽  
Transition Rate ◽  
Ultra High Risk

scholarly journals Further examination of the reducing transition rate in ultra high risk for psychosis samples: The possible role of earlier intervention

2016 ◽  
Vol 174 (1-3) ◽  
pp. 43-49 ◽  
Author(s):  
B. Nelson ◽  
H.P. Yuen ◽  
A. Lin ◽  
S.J. Wood ◽  
P.D. McGorry ◽  
...  
Keyword(s):  
High Risk ◽  
Transition Rate ◽  
Ultra High Risk

Global fractional anisotropy predicts transition to psychosis after 12 months in individuals at ultra‐high risk for psychosis

2021 ◽  
Author(s):  
Tina D. Kristensen ◽  
Louise B. Glenthøj ◽  
Karen Ambrosen ◽  
Warda Syeda ◽  
Jayachandra M. Ragahava ◽  
...  
Keyword(s):  
High Risk ◽  
Fractional Anisotropy ◽  
Ultra High Risk
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