Nitrene Transfer Catalyzed by a Non-Heme Iron Enzyme and Enhanced by Non-Native Small-Molecule Cofactors
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Transition-metal catalysis is a powerful tool for the construction of chemical bonds. Here we show that a non-heme iron enzyme can catalyze olefin aziridination and nitrene C–H insertion, and that these activities can be improved by directed evolution. The non-heme iron center allows for facile modification of the primary coordination sphere by addition of metal-coordinating molecules, enabling control over enzyme activity and selectivity using small molecules.
2019 ◽
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2020 ◽
Vol 2020
(27)
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pp. 2573-2581
2008 ◽
Vol 284
(8)
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pp. 4796-4805
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1980 ◽
Vol 6
(S1)
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pp. 60-61
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2016 ◽
Vol 55
(19)
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pp. 5870-5870