scholarly journals Fast Carbon Isotope Exchange of Carboxylic Acids Enabled by Organic Photoredox Catalysis

2020 ◽  
Author(s):  
Duanyang Kong ◽  
Maxime Munch ◽  
Qiqige Qiqige ◽  
Christopher Cooze ◽  
Benjamin Rotstein ◽  
...  
Keyword(s):  
Transition Metal ◽  
Carbon Isotope ◽  
Carboxylic Acids ◽  
Isotope Exchange ◽  
Room Temperature ◽  
Reaction Times ◽  
Thermally Induced ◽  
Drug Molecules ◽  
Metal Catalyzed ◽  
Isotopic Incorporation

Carbazole/cyanobenzene photocatalysts promote the direct isotopic carboxylate exchange of C(sp3 )-acids with labelled CO2. Substrates that are not compatible with transition metal catalyzed degradation-reconstruction approaches or prone to thermally induced reversible decarboxylation undergo isotopic incorporation at room temperature in short reaction times. The radiolabelling of drug molecules and precursors with [11C]CO2 is demonstrated.

scholarly journals Fast Carbon Isotope Exchange of Carboxylic Acids Enabled by Organic Photoredox Catalysis

2020 ◽  
Author(s):  
Duanyang Kong ◽  
Maxime Munch ◽  
Qiqige Qiqige ◽  
Christopher Cooze ◽  
Benjamin Rotstein ◽  
...  
Keyword(s):  
Transition Metal ◽  
Carbon Isotope ◽  
Carboxylic Acids ◽  
Isotope Exchange ◽  
Room Temperature ◽  
Reaction Times ◽  
Thermally Induced ◽  
Drug Molecules ◽  
Metal Catalyzed ◽  
Isotopic Incorporation

Carbazole/cyanobenzene photocatalysts promote the direct isotopic carboxylate exchange of C(sp3 )-acids with labelled CO2. Substrates that are not compatible with transition metal catalyzed degradation-reconstruction approaches or prone to thermally induced reversible decarboxylation undergo isotopic incorporation at room temperature in short reaction times. The radiolabelling of drug molecules and precursors with [11C]CO2 is demonstrated.

scholarly journals Fast Carbon Isotope Exchange of Carboxylic Acids Enabled by Organic Photoredox Catalysis

2021 ◽  
Vol 143 (5) ◽  
pp. 2200-2206
Author(s):  
Duanyang Kong ◽  
Maxime Munch ◽  
Qiqige Qiqige ◽  
Christopher J. C. Cooze ◽  
Benjamin H. Rotstein ◽  
...  
Keyword(s):  
Carbon Isotope ◽  
Carboxylic Acids ◽  
Isotope Exchange ◽  
Photoredox Catalysis

Efficient synthesis of pyrido[2,3-d]pyrimidine-7-carboxylic acids catalyzed by a TiO2/SiO2 nanocomposite in aqueous media at room temperature

2018 ◽  
Vol 73 (9) ◽  
pp. 641-645 ◽  
Author(s):  
Sepehr Sadegh-Samiei ◽  
Shahrzad Abdolmohammadi
Keyword(s):  
Heterogeneous Catalyst ◽  
Carboxylic Acids ◽  
Room Temperature ◽  
Aqueous Media ◽  
Reaction Times ◽  
Molar Ratio ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
Moderate Reaction ◽  
Recyclable Heterogeneous Catalyst

AbstractA novel and efficient synthesis of eight 5-aryl-1,3-dimethyl-2,4-dioxo-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidine-7-carboxylic acids using a TiO2/SiO2 nanocomposite with a molar ratio of 1:1 as a recyclable heterogeneous catalyst is described. The desired products, five of which are new, are formed in short reaction times (2–3 h) with high to excellent yields (94%–98%) under very moderate reaction conditions (room temperature, aqueous media).

Transition metal-free, visible-light-mediated construction of α,β-diamino esters via decarboxylative radical addition at room temperature

2019 ◽  
Vol 6 (13) ◽  
pp. 2245-2249 ◽  
Author(s):  
Guibing Wu ◽  
Jingwen Wang ◽  
Chengyu Liu ◽  
Maolin Sun ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Transition Metal ◽  
Visible Light ◽  
Carboxylic Acids ◽  
Room Temperature ◽  
Radical Addition ◽  
Metal Free ◽  
Radical Coupling

A metal-free photoredox catalyzed decarboxylative radical coupling of free-carboxylic acids and glyoxylic oximes was developed to synthesize α,β-diamino acids.

scholarly journals Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids

2020 ◽  
Vol 132 (32) ◽  
pp. 13592-13597
Author(s):  
Gianluca Destro ◽  
Kaisa Horkka ◽  
Olivier Loreau ◽  
David‐Alexandre Buisson ◽  
Lee Kingston ◽  
...  
Keyword(s):  
Transition Metal ◽  
Carbon Isotope ◽  
Isotope Exchange ◽  
Free Carbon ◽  
Metal Free ◽  
Acetic Acids

scholarly journals Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids

2020 ◽  
Vol 59 (32) ◽  
pp. 13490-13495 ◽  
Author(s):  
Gianluca Destro ◽  
Kaisa Horkka ◽  
Olivier Loreau ◽  
David‐Alexandre Buisson ◽  
Lee Kingston ◽  
...  
Keyword(s):  
Transition Metal ◽  
Carbon Isotope ◽  
Isotope Exchange ◽  
Free Carbon ◽  
Metal Free ◽  
Acetic Acids
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