Facile Synthesis of Iron-Based MOFs MIL-100(Fe) as Heterogeneous Catalyst in Kabachnick Reaction

An effective technique was proposed for the synthesis of novel α-aminophosphonates: a three-component one-pot condensation reaction of aniline, aromatic aldehydes, and triphenyl phosphite in the presence of (MIL-100(Fe)) as a heterogeneous catalyst. Initially, MIL-100(Fe) was synthesized using H3BTC and ferric nitrate at low temperature and atmospheric pressure. Further, MIL-100(Fe) was characterized using various techniques such as XRD, BET surface area, scanning electron microscopy (SEM), Fourier-transform infrared (FT-IR), and thermogravimetric analysis (TGA). Herein, MIL-100(Fe) showed exceptional catalytic performance for the synthesis of α-aminophosphonate and its derivatives compared with conventional solid catalysts, and even homogeneous catalysts. The study demonstrated that MIL-100(Fe) is an ecofriendly and easily recyclable heterogeneous catalyst in Kabachnick reactions for α-aminophosphonate synthesis, with high yield (98%) and turnover frequency (TOF ~ 3.60 min−1) at room temperature and a short reaction time (30 min).

Poly(N-‎vinylimidazole): A ‎biocompatible‎, efficient, and ‎highly ‎‎recyclable ‎heterogeneous ‎catalyst for ‎the ‎preparation of ‎bis(3-‎‎indolyl)methanes ‎

Poly(N-vinylimidazole) (PVIm), as a biocompatible, efficient, halogen-free, and reusable catalyst, was ‎applied for the solvent-free synthesis of a library of bis(3-indolyl)methanes. The reaction was ‎smoothly carried out under mild conditions, and the crude products were purified easily, and ‎the pure products were obtained in high to excellent yields.‎