A Catalytic Highly Enantioselective Synthesis of Spirooxazolines
Keyword(s):
A catalytic highly enantioselective synthesis of spirooxazolines is presented. Starting from readily available 2-naphthol-substituted benzamides and using catalytic amounts of a chiral triazole-substituted iodoarene catalyst, a variety of spirooxazolines can be isolated through an enantioselective oxidative dearomatization in up to 92% yield and 97% ee. The further synthetic utility of the optically enriched spirooxazolines was examined providing a corresponding 2-naphthalenole and an oxepin.<br>
2008 ◽
Vol 130
(9)
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pp. 2738-2739
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2015 ◽
Vol 2015
(9)
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pp. 2005-2011
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2016 ◽
Vol 55
(48)
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pp. 15115-15119
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