A Simplified Protocol for the ortho-Deuteration of Acidic Aromatic Compounds in D2O
Keyword(s):
<div>Methods to catalytically introduce deuterium in synthetically useful yields ortho to a carboxylic acid directing group on arenes typically requires D2 or CD3CO2D, which makes using these approaches cost prohibitive for large scale synthesis (equipment and reagent costs respectively). Herein we present a simplified approach using catalytic RhIII and D2O as deuterium source, and show its application to H/D exchange on various acidic substrates.</div>
2019 ◽
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2009 ◽
Vol 87
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pp. 1675-1681
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2000 ◽
Vol 4
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pp. 460-466
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2001 ◽
Vol 31
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pp. 3533-3536
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2019 ◽
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2006 ◽
Vol 10
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pp. 534-538
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