Infleunce of Body Mass Index (BMI) on Outcome of Colon Cancer in Relationships with Other Clinicopathological  Factors

Background: Colon cancer is the third most common cancer. High (BMI) contributes hazardously for several types of malignancies including colon cancer while the effect of BMI as a prognostic factor is poorly defined. Objective: Demonstrating the influence of increasing (BMI) on colon cancer recurrence. Patients and Methods: Case-control study involved a sample of 312 patients and 131 patients were excluded from this study and only 181 patients of colon cancer are included in the study with stage 2 and 3 who did underwent a surgical operation and received adjuvant chemotherapy recruited from an oncology teaching hospital, Al Jawad oncology center (Alkadhemiya hospital) and Babylon Oncology center. Results: The study involved 181 patients of colon cancer patients with mean age of 56.25 ±11.74years the highest proportion of study patients (90.6%) were aged more than 40yrs with a male to female ratio (1.2:1). Overweight patients constituted 39.2% and obese 23.8% and normal body weight 37%. In this study majority of tumors are ulcerating for about 72.5% and sigmoid and left side colon was the most common site of the tumor in about 53% with stage three is a most common type. Regarding recurrence, 54.1% of study patients have recurrence, and the majority of the 41.8% occurs between 1-3years after primary tumors diagnoses and treatment with a high prevalence of recurrence was seen in obese patients (74.4%) with a significant association between prevalence of recurrence and increasing BMI. In this study, 61.2% of patients with lymphovascular invasion have recurrences of malignancy with significant associations between recurrences and LVIe. Also more than 50% of patient older than 40years got recurrences with significant associations between recurrences with age of patients. In this study we take the effect of each clinicopathological feature on the outcome of colon cancer and then to excluded its effect by logistic regression to see the effect of only BMI on the outcome of colon cancer. Conclusion: Increase body mass index is associated with increase recurrence of colon cancer Keywords: Colon cancer recurrence, body mass index, Clinicopathological Factors

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Impact of Body Mass Index and Weight Change After Treatment on Cancer Recurrence and Survival in Patients With Stage III Colon Cancer: Findings From Cancer and Leukemia Group B 89803

Journal of Clinical Oncology ◽

10.1200/jco.2007.15.6687 ◽

2008 ◽

Vol 26 (25) ◽

pp. 4109-4115 ◽

Cited By ~ 170

Author(s):

Jeffrey A. Meyerhardt ◽

Donna Niedzwiecki ◽

Donna Hollis ◽

Leonard B. Saltz ◽

Robert J. Mayer ◽

...

Keyword(s):

Body Mass Index ◽

Colon Cancer ◽

Adjuvant Chemotherapy ◽

Body Mass ◽

Weight Change ◽

Cancer Recurrence ◽

Stage Iii ◽

Stage Iii Colon Cancer ◽

Chemotherapy Patients ◽

Risk Of Cancer

Purpose Obesity is a risk factor for the development of colon cancer. However, the influence of body mass index (BMI) on the outcome of patients with established colon cancer remains uncertain. Moreover, the impact of change in body habitus after diagnosis has not been studied. Patients and Methods We conducted a prospective, observational study of 1,053 patients who had stage III colon cancer and who were enrolled on a randomized trial of adjuvant chemotherapy. Patients reported on height and weight during and 6 months after adjuvant chemotherapy. Patients were observed for cancer recurrence or death. Results In this cohort of patients with stage III cancer, 35% of patients were overweight (BMI, 25 to 29.9 kg/m2), and 34% were obese (BMI ≥ 30 kg/m2). Increased BMI was not significantly associated with a higher risk of colon cancer recurrence or death (P trend = .54). Compared with normal-weight patients (BMI, 21 to 24.9 kg/m2), the multivariate hazard ratio for disease-free survival was 1.00 (95% CI, 0.72 to 1.40) for patients with class I obesity (BMI, 30 to 34.9 kg/m2) and 1.24 (95% CI, 0.84 to 1.83) for those with class II to III obesity (BMI ≥ 35 kg/m2) after analysis was adjusted for tumor-related prognostic factors, physical activity, tobacco history, performance status, age, and sex. Similarly, after analysis was controlled for BMI, weight change (either loss or gain) during the time period between ongoing adjuvant therapy and 6 months after completion of therapy did not significantly impact on cancer recurrence and/or mortality. Conclusion Neither BMI nor weight change was significantly associated with an increased risk of cancer recurrence and death in patients with colon cancer.

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Western Diet May Increase Colon Cancer Recurrence

Clinical Psychiatry News ◽

10.1016/s0270-6644(07)70731-2 ◽

2007 ◽

Vol 35 (11) ◽

pp. 40

Author(s):

MARY ANN MOON

Keyword(s):

Colon Cancer ◽

Cancer Recurrence ◽

Western Diet ◽

Colon Cancer Recurrence

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Prevalence of IgA Nephropathy: A 10 Years’ Experience from Jinnah Postgraduate Medical Centre, Karachi, Pakistan

Pakistan Journal of Medicine and Dentistry ◽

10.36283/pjmd9-4/003 ◽

2020 ◽

Keyword(s):

Body Mass Index ◽

Iga Nephropathy ◽

Body Mass ◽

Immunoglobulin A ◽

Medical Centre ◽

Male Dominance ◽

Clinical Indication ◽

Glomerular Lesion ◽

Female Ratio ◽

Nephritic Syndrome

Background: Immunoglobulin A (IgA) is considered the most frequently dealt primary glomerulonephritis, worldwide. The Berger’s disease or IgA nephropathy is a mesangial proliferative glomerulonephritis characterized by deposition of immunoglobulin A in kidneys. The aim of the study was to report the prevalence of IgA nephropathy and the associated parameters (age, gender, and body mass index) in our population. Methods: This was a retrospective study, accomplished at Jinnah Postgraduate Medical Centre, Karachi, Pakistan, from June 2009-May 2019. The histopathology and immunofluorescence of renal biopsies of 519 patients were studied and the prevalence of biopsy proven IgA nephropathy was determined. The Chi-square test was used for association of biopsy proven IgA nephropathy with age, gender, and body mass index. A p-value of 0.05 or less was considered statistically significant. Results: A total of 519 biopsies were studied, out of those, only 4 (0.8%) had IgA nephropathy with male dominance in the last 10 years at Karachi, Pakistan. Male to female ratio was found to be 3:1. The most common clinical indication for renal biopsy was isolated hematuria in 50% of the cases followed by acute kidney injury and nephritic syndrome with 25% each respectively. Most of the patients suffering from proteinuria (> 3.5gm/24 hours), microscopic hematuria in 80% cases, high blood pressure in 50% cases, with other associated symptoms including edema, gastrointestinal, and skin-related symptoms reported. Conclusion: Immunoglobulin A (IgA) nephropathy is not a commonly diagnosed glomerular lesion. Further large-scale cohorts can aid in determining the other factors associated with a low frequency of IgA nephropathy. Keywords: Biopsy; Glomerulonephritis; Immunoglobulin A; Nephropathy.

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