scholarly journals Correlation between IRS2 gene polymorphism abnormalities of insulin resistance and lipid profile in polycystic ovarian syndrome women

2019 ◽  
Vol 12 (3) ◽  
pp. 88-93
Author(s):  
B Bhanuja Rani ◽  
◽  
Devi Kinnera T ◽  
C V Sarada ◽  
Lavanya . ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Gene Polymorphism ◽  
Lipid Profile ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome

scholarly journals Insulin Resistance and Homocysteine Levels in Patients with Polycystic Ovarian Syndrome

2013 ◽  
Vol 5 (2) ◽  
pp. 49-51
Author(s):  
Suresh Chari ◽  
Sunita Ghike ◽  
Madhur Mahesh Gupta ◽  
Manju Chandankhede
Keyword(s):  
Insulin Resistance ◽  
Lipid Profile ◽  
Polycystic Ovarian Syndrome ◽  
Case Control Study ◽  
Cardiovascular Complications ◽  
Healthy Controls ◽  
Short Term ◽  
Ovarian Syndrome ◽  
Control Study

ABSTRACT Objectives To assess association in between insulin resistance and homocysteine levels in patients with polycystic ovarian syndrome (PCOS). Methods A case control study. Setting Hospital based. Patients Forty females diagnosed with PCOS were matched with 40 normal healthy controls. Intervention Blood samples for insulin, lipid profile, fasting glucose and homocysteine measurements. Results Our study suggests that PCOS patients have insulin resistance, dyslipidemia and hyperhomocysteinemia when compared with normal healthy controls. Conclusion To determine the short-term implications of reproductive performance and long-term implications regarding cardiovascular complications associated with PCOS the assessment of insulin resistance, lipid profile along with homocysteine levels in patients of PCOS is warranted. How to cite this article Gupta MM, Chari S, Chandankhede M, Ghike S. Insulin Resistance and Homocysteine Levels in Patients with Polycystic Ovarian Syndrome. J South Asian Feder Obst Gynae 2013;5(2):49-51.

Association of Interleukin 6 and insulin resistance gene polymorphism with polycystic ovarian syndrome: A meta-analysis

Meta Gene ◽  
2020 ◽  
Vol 24 ◽  
pp. 100675 ◽  
Author(s):  
D. Goussalya ◽  
M.S. Jancy ◽  
A. Anolin Jemi ◽  
R. Soundarya ◽  
Sindhu Varghese ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Gene Polymorphism ◽  
Resistance Gene ◽  
Interleukin 6 ◽  
Polycystic Ovarian Syndrome ◽  
Meta Analysis ◽  
Ovarian Syndrome

Polycystic ovarian syndrome: Correlation between hyperandrogenism, insulin resistance and obesity

2020 ◽  
Vol 502 ◽  
pp. 214-221 ◽  
Author(s):  
Xin Zeng ◽  
Yuan-jie Xie ◽  
Ya-ting Liu ◽  
Shuang-lian Long ◽  
Zhong-cheng Mo
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome

scholarly journals Role of insulin sensitising agents in altering PSA level in PCOS

2017 ◽  
Vol 6 (11) ◽  
pp. 4986 ◽  
Author(s):  
Rajashree Panigrahy ◽  
Bratati Singh ◽  
Tapan K. Pattnaik ◽  
Sanjukta Misra
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovarian Syndrome ◽  
Specific Antigen ◽  
Serum Testosterone ◽  
Healthy Controls ◽  
Androgen Excess ◽  
Control Serum ◽  
Ovarian Syndrome ◽  
Significant Concentration

Background: Ovarian androgen production can be promoted by insulin resistance which leads to reproductive abnormalities in Polycystic Ovarian Syndrome (PCOS). A wide variety of female tissues can synthesize and secrete Prostate Specific Antigen (PSA). Androgens may take part a significant role in PSA secretion in PCOS. As insulin resistance stimulates androgen production, the baseline value of PSA may decline by insulin sensitising agents in PCOS. Present study is an attempt to measure the function of PSA as a marker of androgen excess in PCOS and to assess the role of insulin sensitising agent metformin in altering PSA level in PCOS.Methods: The study was undertaken to assess the insulin resistance, testosterone and PSA level in 45 women diagnosed as PCOS and 45 healthy controls. Alteration of insulin resistance, serum testosterone and PSA levels by metformin was also analysed.Results: A significant increase in testosterone, PSA level and insulin resistance was observed in PCOS cases when compared with control (p<0.001). When metformin was given for 4 months, improvement in insulin resistance and testosterone level was found in cases, but PSA values observed no change. Correlation was not found linking insulin resistance with PSA level prior to and after therapy.Conclusions: Serum PSA level could be detected in high significant concentration in PCOS women. Various researches explain that insulin resistance and BMI may perhaps control serum PSA level, but our result demonstrate no effect of insulin sensitising agent on serum PSA value.

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