scholarly journals Azole-resistant invasive aspergillosis in a patient with acute myeloid leukaemia in Germany

2012 ◽  
Vol 17 (36) ◽  
Author(s):  
A Hamprecht ◽  
D Buchheidt ◽  
J J Vehreschild ◽  
O A Cornely ◽  
B Spiess ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Invasive Aspergillosis ◽  
Aspergillus Fumigatus ◽  
Myeloid Leukaemia ◽  
Susceptibility Testing ◽  
Resistance Mechanism ◽  
Azole Resistance ◽  
Breakthrough Infection ◽  
Proven Case ◽  
Acute Myeloid

We report the first culture-proven case of invasive aspergillosis (IA) caused by azole-resistant Aspergillus fumigatus in a patient with acute myeloid leukaemia in Germany. IA presented as breakthrough infection under posaconazole prophylaxis. Analysis of the resistance mechanism revealed the TR/L98H mutation in the cyp51A gene, which indicates an environmental origin of the strain. This case underscores the need for monitoring azole resistance in Aspergillus spp. and for routine susceptibility testing of moulds.

Primary aspergillosis of the larynx causing acute airway distress

2021 ◽  
Vol 14 (4) ◽  
pp. e240434
Author(s):  
David Ranford ◽  
Chong Kang ◽  
Mairead Kelly ◽  
Luigi Volpini
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Invasive Aspergillosis ◽  
Aspergillus Fumigatus ◽  
Immunocompromised Patient ◽  
Secondary Infection ◽  
Tracheobronchial Tree ◽  
Emergency Intervention ◽  
Recent Diagnosis ◽  
Cord Lesion ◽  
Acute Myeloid

Laryngeal aspergillosis is most commonly seen as a secondary infection that spreads from the lungs and tracheobronchial tree. Primary invasive aspergillosis of the larynx is rare and most likely seen in an immunocompromised patient. We present a case of a 59-year-old woman who presented with progressive dysphonia and subsequently acute stridor. She is a non-smoker with a recent diagnosis of acute myeloid leukaemia. Fibreoptic nasendoscopy revealed a left sided vocal cord lesion ball valving into the glottic space. Histology taken during emergency debulking confirmed Aspergillus fumigatus and the patient was successfully treated with intravenous antifungals. Although there are cases of primary laryngeal aspergillosis discussed in the literature, to the best of our knowledge this is the first reported case to have caused acute airway distress requiring emergency intervention.

Aspergillus fumigatus endophthalmitis in a patient with acute myeloid leukaemia

1999 ◽  
Vol 21 (2) ◽  
pp. 143-144 ◽  
Author(s):  
G. A. Follows ◽  
C. Hutchinson ◽  
A. Martin ◽  
C. Carter
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Aspergillus Fumigatus ◽  
Myeloid Leukaemia ◽  
Acute Myeloid

scholarly journals Progressive Dispersion of Azole Resistance in Aspergillus fumigatus: Fatal Invasive Aspergillosis in a Patient with Acute Myeloid Leukemia Infected with an A. fumigatus Strain with a cyp51A TR46 Y121F M172I T289A Allele

2017 ◽  
Vol 61 (8) ◽  
Author(s):  
Susann Rößler ◽  
Oliver Bader ◽  
Friedrich Stölzel ◽  
Ulrich Sommer ◽  
Birgit Spiess ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Invasive Aspergillosis ◽  
Aspergillus Fumigatus ◽  
Myeloid Leukemia ◽  
Treatment Options ◽  
Hematologic Malignancies ◽  
Azole Resistance ◽  
Hematopoietic Stem ◽  
Content Type ◽  
Acute Myeloid

ABSTRACT Patients with hematologic malignancies as well as allogeneic hematopoietic stem cell transplantation (HSCT) patients are at high risk for invasive aspergillosis. Here, we report a culture- and autopsy-proven fatal invasive aspergillosis in an allogeneic HSTC patient which he developed despite posaconazole prophylaxis. The agent was determined to be an azole-resistant Aspergillus fumigatus strain bearing the cyp51A mutation combination TR46 Y121F M172I T289A. At increasing frequency, the azole resistance of A. fumigatus is being reported globally, limiting treatment options and complicating regimens.

Impact of invasive aspergillosis occurring during first induction therapy on outcome of acute myeloid leukaemia (SEIFEM‐12B study)

Mycoses ◽  
2020 ◽  
Vol 63 (10) ◽  
pp. 1094-1100
Author(s):  
Anna Candoni ◽  
Francesca Farina ◽  
Katia Perruccio ◽  
Roberta Di Blasi ◽  
Marianna Criscuolo ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Invasive Aspergillosis ◽  
Myeloid Leukaemia ◽  
Induction Therapy ◽  
Acute Myeloid

scholarly journals Azole-resistant Aspergillus fumigatus due to TR46/Y121F/T289A mutation emerging in Belgium, July 2012

2012 ◽  
Vol 17 (48) ◽  
Author(s):  
E Vermeulen ◽  
J Maertens ◽  
H Schoemans ◽  
K Lagrou
Keyword(s):  
The Netherlands ◽  
Invasive Aspergillosis ◽  
Aspergillus Fumigatus ◽  
Resistance Mechanism ◽  
Azole Resistance ◽  
Invasive Infection ◽  
Susceptibility Pattern ◽  
Therapy Failure ◽  
First Case ◽  
Phenotypic Susceptibility

A new azole resistance mechanism in Aspergillus fumigatus consisting of a TR46/Y121F/T289A alteration in the cyp51A gene was recently described in the Netherlands. Strains containing these mutations are associated with invasive infection and therapy failure. This communication describes the first case of fatal invasive aspergillosis caused by TR46/Y121F/T289A outside the Netherlands, in the neighboring country of Belgium, suggesting geographical spread. TR46/Y121F/T289A leads to a recognisable phenotypic susceptibility pattern which should trigger cyp51A genotyping to monitor further spread.

The acute myeloid leukaemia market

2019 ◽  
Vol 19 (4) ◽  
pp. 233-234
Author(s):  
Jorrit Schaefer ◽  
Sorcha Cassidy ◽  
Rachel M. Webster
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Acute Myeloid
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