scholarly journals Decline in the incidence of variant Creutzfeldt-Jakob disease in the UK

2003 ◽  
Vol 7 (10) ◽  
Author(s):  
N Andrews ◽  
A Molesworth
Keyword(s):  
United Kingdom ◽  
Symptom Onset ◽  
Expected Number ◽  
Short Term ◽  
The United Kingdom ◽  
Jakob Disease ◽  
The Uk ◽  
Number Of Individuals ◽  
Underlying Trend

By the end of December 2002 the number of cases of confirmed or probable variant Creutzfeldt-Jakob Disease (CJD) reported in the United Kingdom (UK) had reached a total of 129 (http://www.doh.gov.uk/cjd/stats/jan03.htm). Quarterly analyses are performed that estimate the underlying trend in vCJD incidence. These enable short term predictions for the expected number of deaths in the next year as well as estimates of the total number of individuals with symptom onset yet to be identified (http://www.cjd.ed.ac.uk/vcjd.htm).

scholarly journals Incidence trends and short term predictions for variant Creutzfeldt-Jakob disease in the United Kingdom – update

2002 ◽  
Vol 6 (30) ◽  
Author(s):  
N J Andrews
Keyword(s):  
United Kingdom ◽  
Symptom Onset ◽  
Expected Number ◽  
Short Term ◽  
Incidence Trends ◽  
The United Kingdom ◽  
Jakob Disease ◽  
Number Of Individuals ◽  
Underlying Trend

By the end of June 2002, a total of 124 cases of variant Creutzfeldt-Jakob disease (vCJD) had been reported in the United Kingdom (http://www.doh.gov.uk/cjd/stats/jul02.htm). In order to monitor the underlying trend in vCJD incidence, quarterly analyses that estimate the underlying trend are performed. The models fitted to the data enable short term predictions for the expected number of deaths in the next year, as well as an estimate of the total number of individuals with symptom onset who are yet to be identified.

scholarly journals Tonsil study provides estimate of the number of people in the UK who could be incubating vCJD

2004 ◽  
Vol 8 (24) ◽  
Author(s):  
C Kelly
Keyword(s):  
United Kingdom ◽  
The United Kingdom ◽  
Jakob Disease ◽  
The Uk ◽  
Number Of Individuals

A study providing an estimate of the number of individuals in the United Kingdom (UK) who may be incubating variant Creutzfeldt-Jakob disease (vCJD), has recently been published

scholarly journals Incidence trends and short term predictions for variant Creutzfeldt-Jakob disease in the United Kingdom

2001 ◽  
Vol 5 (46) ◽  
Author(s):  
N J Andrews
Keyword(s):  
United Kingdom ◽  
Birth Cohort ◽  
Short Term ◽  
Incidence Trends ◽  
The United Kingdom ◽  
Jakob Disease ◽  
Underlying Trend

By the beginning of November 2001, the total number of cases of variant Creutzfeldt-Jakob disease (vCJD) reported in the United Kingdom had reached 111 (www.doh.gov.uk/cjd/stats/nov01.htm). To monitor the underlying trend in vCJD incidence and identify any differences in this trend by factors such as birth cohort and sex, quarterly analyses are performed which estimate the underlying trend.

scholarly journals Latest quarterly analysis of variant Creutzfeldt-Jakob disease incidence in the UK shows continued slow-down

2003 ◽  
Vol 7 (18) ◽  
Author(s):  
N J Andrews
Keyword(s):  
United Kingdom ◽  
Disease Incidence ◽  
The United Kingdom ◽  
Jakob Disease ◽  
The Uk

Five new cases of variant Creutzfeldt-Jakob disease (vCJD) were diagnosed in the United Kingdom (UK) in the first quarter of 2003, bringing the total number of confirmed or probable cases to 134 (1). Five deaths occurred in the first quarter, bringing the total number of deaths to 126. The total number of onsets and deaths by year are shown in the table.

scholarly journals vCJD incidence in the UK shows evidence of having peaked or reached a plateau

2004 ◽  
Vol 8 (6) ◽  
Author(s):  
N J Andrews
Keyword(s):  
United Kingdom ◽  
The United Kingdom ◽  
Jakob Disease ◽  
The Uk

A total of 18 deaths from variant Creutzfeldt-Jakob disease (vCJD) were reported in 2003 in the United Kingdom.

scholarly journals Preliminary Case Report on the SARS-CoV-2 Cluster in the UK, France, and Spain

2020 ◽  
Author(s):  
Emma B. Hodcroft
Keyword(s):  
United Kingdom ◽  
Case Report ◽  
Large Cluster ◽  
Severe Illness ◽  
Apparent Absence ◽  
Ski Resort ◽  
The United Kingdom ◽  
The Uk ◽  
Available Information ◽  
Number Of Individuals

Almost half of the confirmed COVID-19 cases detected so far in the United Kingdom are part of a large cluster of 13 British nationals who tested positive for SARS-CoV-2 in the UK, Spain, and France. Transmissions among this cluster occurred at a ski resort in France, and originated from a single infected traveller returning from a conference in Singapore where he acquired the virus. At least 21 individuals were exposed to the virus, tested, and quarantined, with 13 of those testing positive between the period of 6th Feb and 15th Feb. Here, all publicly available information about the primarily UK/France cluster is consolidated, providing a complete and accessible summary of the cases and their connections. Notable in this cluster are the number of individuals infected, the apparent absence of any severe illness among those infected, and a case of a `delayed positive' test during isolation after initially testing negative, at least 7 days after last possible contact.

scholarly journals Fourth case of transfusion-associated vCJD infection in the United Kingdom

2007 ◽  
Vol 12 (3) ◽  
Author(s):  
Collective Editorial team
Keyword(s):  
United Kingdom ◽  
Blood Transfusion ◽  
Fourth Case ◽  
The United Kingdom ◽  
Jakob Disease ◽  
The Uk

A case of variant Creutzfeldt-Jakob disease (vCJD) has recently been diagnosed in a patient in the United Kingdom (UK), who received a blood transfusion from a donor who later developed vCJD. This is the fourth case of probable transfusion transmission of vCJD infection in the UK. Three of the four recipients developed symptoms of vCJD.

scholarly journals Possible second case of variant CJD prion protein transmission from blood transfusion in the UK

2004 ◽  
Vol 8 (31) ◽  
Author(s):  
Keyword(s):  
United Kingdom ◽  
Blood Transfusion ◽  
Prion Protein ◽  
The United Kingdom ◽  
Jakob Disease ◽  
The Uk

A possible second case of transmission of the abnormal prion protein associated with variant Creutzfeldt-Jakob disease (vCJD) through a blood transfusion in the United Kingdom

scholarly journals First Indications for Long-Term Benzodiazepine and Z-drugs use in the United Kingdom

2016 ◽  
Author(s):  
James Davies ◽  
Todd Rae ◽  
Luke Montagu
Keyword(s):  
United Kingdom ◽  
National Level ◽  
Evidence Based ◽  
Short Term ◽  
Strong Case ◽  
The North ◽  
The United Kingdom ◽  
Hypnotic Drugs ◽  
The Uk

Benzodiazepines and Z-drugs (BZDs), hypnotic drugs used for insomnia and anxiety, are prescribed millions of times a year in the UK. Although guidance from the relevant regulatory authorities (NICE and BNF) indicates them only for short-term use, the evidence suggests that many patients have been taking these drugs for much longer, often for decades. At present, there are no up-to-date, evidence-based estimates of the scale of long-term BZD use in the UK, which has prevented making a strong case for the need for withdrawal services. However, data obtained recently on BZD use from a number of GP surgeries (covering nearly 100,000 registered patients) in the North of England, allow such projections to be calculated. Scaling the results to a national level suggests that there are over a quarter of a million patients in the UK using BZDs for periods far longer than recommended. The projections also suggest that nearly half this number may be willing to accept help to stop their dependency on BZDs. These results indicate a serious problem, which should be addressed by more research into the harms associated with long-term BZD use, the provision of withdrawal services, and a national helpline to support patients with BZD dependency.

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