scholarly journals Penentuan Komposisi Hidroksiapatit-Alginat-Zinc terhadap Kuat Tekan Bone Scaffold dengan Metode Taguchi

2021 ◽  
Vol 1 (1) ◽  
pp. 1-8
Author(s):  
Febbyola Raflyani ◽  
Tri Wibawa ◽  
Sadi Sadi
Keyword(s):  
Bone Graft ◽  
Bone Scaffold

Indonesia merupakan negara berkembang dengan tingkat mobilitas masyarakat yang berkendara cukup tinggi. Seiring dengan bertambahnya kebutuhan transportasi menyebabkan tingkat kecelakaan lalu lintas juga semakin meningkat. Permasalahan ini menyebabkan luka hingga patah tulang bagi para korban. Untuk menangani masalah tersebut, perlu diadakannya pencangkokan tulang (bone graft). Pada penelitian ini akan dirancang material tulang pengganti manusia yang berasal dari campuran Hidroksiapatit dengan Alginat dan Zinc. Hasil pencampuran material akan dilakukan pengujian kuat tekan dan data akan diolah dengan menggunakan metode Taguchi. Target uji tekan yaitu 7,5-41 MPa dengan karakteristik kualitas larger-the-better. Sedangkan desain eksperimen yang digunakan yaitu L423. Hasil dari perhitungan ANOVA menunjukkan bahwa faktor komposisi HA, komposisi Alginat, dan rasio HA:Aquades memiliki hasil yang signifikan. Terhadap kuat tekan scaffold. Namun, hasil perhitungan ANOVA terhadap nilai SNR menunjukkan bahwa ketiga faktor tersebut tidak memiliki kontribusi pada pengurangan variansi suatu karakteristik kualitas. Komposisi material scaffold yang paling optimal yaitu komposisi HA 88%wt, komposisi Alginat 8%wt, dan rasio HA:Aquades 1:1,5. Hasil nilai kuat tekan pada komposisi tersebut sebesar 8,197±0,259 MPa dimana nilai ini sesuai dengan nilai kuat tekan untuk tulang cancellous.

scholarly journals Individualized plasticity autograft mimic with efficient bioactivity inducing osteogenesis

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Yan Wei ◽  
Guixin Zhu ◽  
Zifan Zhao ◽  
Chengcheng Yin ◽  
Qin Zhao ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Graft ◽  
Secondary Trauma ◽  
Bone Grafts ◽  
Bone Scaffold ◽  
Fiber Network ◽  
Marrow Mesenchymal Stem Cells ◽  
Limited Application ◽  
Osteogenic Induction ◽  
Scaffold Materials

AbstractMineralized tissue regeneration is an important and challenging part of the field of tissue engineering and regeneration. At present, autograft harvest procedures may cause secondary trauma to patients, while bone scaffold materials lack osteogenic activity, resulting in a limited application. Loaded with osteogenic induction growth factor can improve the osteoinductive performance of bone graft, but the explosive release of growth factor may also cause side effects. In this study, we innovatively used platelet-rich fibrin (PRF)-modified bone scaffolds (Bio-Oss®) to replace autograft, and used cytokine (BMP-2) to enhance osteogenesis. Encouragingly, this mixture, which we named “Autograft Mimic (AGM)”, has multiple functions and advantages. (1) The fiber network provided by PRF binds the entire bone scaffold together, thereby shaping the bone grafts and maintaining the space of the defect area. (2) The sustained release of BMP-2 from bone graft promoted bone regeneration continuously. (3) AGM recruited bone marrow mesenchymal stem cells (BMSCs) and promote their proliferation, migration, and osteogenic differentiation. Thus, AGM developed in this study can improve osteogenesis, and provide new guidance for the development of clinical bone grafts.

scholarly journals A Decellularized Porcine Xenograft-Derived Bone Scaffold for Clinical Use as a Bone Graft Substitute: A Critical Evaluation of Processing and Structure

2018 ◽  
Vol 9 (3) ◽  
pp. 45 ◽  
Author(s):  
Daniel Bracey ◽  
Thorsten Seyler ◽  
Alexander Jinnah ◽  
Mark Lively ◽  
Jeffrey Willey ◽  
...  
Keyword(s):  
Bone Graft ◽  
Disease Transmission ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Critical Evaluation ◽  
Bone Graft Substitute ◽  
Clinical Use ◽  
Bone Scaffold ◽  
Proteomics Data ◽  
Porcine Xenograft

Background: Bone grafts are used in approximately one half of all musculoskeletal surgeries. Autograft bone is the historic gold standard but is limited in supply and its harvest imparts significant morbidity to the patient. Alternative sources of bone graft include allografts, synthetics and, less commonly, xenografts which are taken from animal species. Xenografts are available in unlimited supply from healthy animal donors with controlled biology, avoiding the risk of human disease transmission, and may satisfy current demand for bone graft products. Methods: In the current study, cancellous bone was harvested from porcine femurs and subjected to a novel decellularization protocol to derive a bone scaffold. Results: The scaffold was devoid of donor cellular material on histology and DNA sampling (p < 0.01). Microarchitectural properties important for osteoconductive potential were preserved after decellularization as shown by high resolution imaging modalities. Proteomics data demonstrated similar profiles when comparing the porcine bone scaffold against commercially available human demineralized bone matrix approved for clinical use. Conclusion: We are unaware of any porcine-derived bone graft products currently used in orthopaedic surgery practice. Results from the current study suggest that porcine-derived bone scaffolds warrant further consideration to serve as a potential bone graft substitute.

A porcine xenograft‐derived bone scaffold is a biocompatible bone graft substitute: An assessment of cytocompatibility and the alpha‐Gal epitope

2019 ◽  
Vol 26 (5) ◽  
Author(s):  
Daniel N. Bracey ◽  
Thorsten M. Seyler ◽  
Alexander H. Jinnah ◽  
Thomas L. Smith ◽  
David A. Ornelles ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Graft Substitute ◽  
Bone Scaffold ◽  
Porcine Xenograft

Gastrocnemius-Fibular Flap. A New Pedicled Vascularized Bone Graft Alternative for Femur Pseudarthrosis. Review of 7 Consecutive Clinical Cases

2014 ◽  
Vol 30 (S 01) ◽  
Author(s):  
Luciano Torres ◽  
Fernanda Bogdanovics ◽  
Paganotti Guilherme ◽  
Pelosini Gaiarsa ◽  
José Queiroz ◽  
...  
Keyword(s):  
Bone Graft ◽  
Vascularized Bone Graft ◽  
Fibular Flap ◽  
Vascularized Bone ◽  
Clinical Cases

Arthrodesis of the Distal Two Tarsal Joints in the Horse Using Perforated Stainless Steel Cylinders and Cancellous Bone Graft

1991 ◽  
Vol 4 (01) ◽  
pp. 21-27 ◽  
Author(s):  
R. M. Archer ◽  
R. K. Schneider
Keyword(s):  
Stainless Steel ◽  
Bone Graft ◽  
Cancellous Bone ◽  
Cancellous Bone Graft ◽  
The Third ◽  
Partial Fusion

SummaryTwo perforated stainless steel cylinders and autogenous cancellous bone were implanted into each of the distal intertarsal and tarsometatarsal joints of seven horses. In two control horses holes were drilled into each joint and autogenous cancellous bone was implanted without stainless steel cylinders. Horses which had cylinders implanted in the distal tarsal joints exhibited less lameness and were more comfortable following surgery than were the control horses. Fracture of the third tarsal, central tarsal, or third metatarsal occurred in five of the seven horses implanted with stainless steel cylinders within 45 days of surgery. Two implanted horses and two control horses were observed for five months after surgery. Partial fusion of the distal tarsal joints occurred in all four horses. Control horses were more lame than the implanted horses and developed a large bony exostosis over the medial distal tarsus.

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