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Alessio Danilo Inchingolo ◽  
Assunta Patano ◽  
Giovanni Coloccia ◽  
Sabino Ceci ◽  
Angelo Michele Inchingolo ◽  

Background: Elastodontics is a specific interceptive orthodontic treatment that uses removable elastomeric appliances. They are functional appliances that produce neuromuscular, orthopedic and dental effects. Thus, these devices are useful in the developmental age, when skeletal structures are characterized by important plasticity and adaptation capacity, allowing to remove factors responsible for malocclusions. Elastomeric devices are generally well tolerated by patients requiring simple collaboration and management. This work can be useful to update all orthodontists already adopting these appliances or for those who want to approach them for the first time. This study aimed to describe four cases treated with new elastomeric devices called AMCOP Bio-Activators and to provide an overview of elastodontics, its evolution, indications and limits. Methods: A total of four clinical cases were presented after a treatment period of 16–20 months to evaluate the clinical and radiological effects of the elastodontic therapy. Results: The effectiveness of Bio-Activators on clinical cases was evidenced with a significant improvement in skeletal and dentoalveolar relationship, and malocclusion correction in a limited treatment period (16–20 months). Conclusions: The Bio-Activators showed clinical effectiveness to achieve therapeutic targets according to a low impact on the patient’s compliance.

Cristina Gasparik ◽  
Horațiu Alexandru Colosi ◽  
Bianca Elena Varvara ◽  
Alexandru Grațian Grecu ◽  
Alexandra Iulia Aghiorghiesei ◽  

Dyschromic lesions (DLs) of tooth enamel are common disorders, with multiple etiologies and various clinical forms, that raise public health concerns. This study aimed to determine the factors that influence the perception of DLs and to assess the perceived need for dental treatment in various clinical cases. A paper-based questionnaire with attached images of frontal teeth exhibiting different DLs was distributed to patients, dental students, and dentists. A total of 383 volunteers participated in this study, and their answers were statistically described and analyzed. This study found that in cases with multiple, well-demarcated areas of opacities associated with diffuse opacities on neighboring teeth, most respondents noticed and reported only the most severe lesions, disregarding the minor ones. The contrast of the lesion with the color of the substrate influenced the overall perception and a significant correlation between these two variables was found. However, the color of the DLs did not significantly impact the overall perception of the lesions. A higher overall perception of DLs was significantly correlated with a favorable opinion regarding the need for treatment. Furthermore, gender and medical background were significantly associated with the overall perception of DLs.

N. E. Ballesteros-Nova ◽  
S. Sánchez ◽  
J. L. Steffani ◽  
L. C. Sierra ◽  
Z. Chen ◽  

Salmonella enterica (SE) can survive in surface waters (SuWa) and the role of non-host environments in its transmission has acquired increasing relevance. In this study, we conducted comparative genomic analyses of 172 SE isolates collected from SuWa across three months in six states of central Mexico during 2019. SE transmission dynamics were assessed using 87 experimental and 112 public isolates from Mexico collected during 2002-2019. We also studied genetic relatedness between SuWa isolates and human clinical strains collected in North America during 2005-2020. Among experimental isolates, we identified 41 SE serovars and 56 multi-locus sequence types (ST). Predominant serovars were Senftenberg (n=13), Meleagridis, Agona, and Newport (n=12 each), Give (n=10), Anatum (n=8), Adelaide (n=7), and Infantis, Mbandaka, Ohio and Typhimurium (n=6 each). We observed a high genetic diversity in the sample under study, as well as clonal dissemination of strains across distant regions. Some of these strains are epidemiologically important (ST14, ST45, ST118, ST132, ST198, and ST213), and were genotypically close to those involved in clinical cases in North America. Transmission network analysis suggests that SuWa are a relevant source of SE (0.7 source/hub ratio) and contributes to its dissemination as isolates from varied sources and clinical cases have SuWa isolates as common ancestors. Overall, the study shows SuWa act as reservoir of various SE serovars of public health significance. Further research is needed to better understand the mechanisms involved in SuWa contamination by SE, as well as develop interventions to contain its dissemination to food production settings. Study importance Surface waters are heavily used in food production worldwide. Several human pathogens can survive in these waters for long periods and disseminate to food production environments, contaminating our food supply. One of these pathogens is Salmonella enterica , a leading cause of foodborne infections, hospitalizations and deaths in many countries. This research demonstrates the role of surface waters as a vehicle for the transmission of Salmonella along food production chains. It also shows some strains circulating in surface waters are very similar to those implicated in human infections and harbor genes that confer resistance to multiple antibiotics, posing a risk to public health. The study contributes to expand our current knowledge on the ecology and epidemiology of Salmonella in surface waters.

Shannon Kilburn ◽  
Gabriel Innes ◽  
Monica Quinn ◽  
Karen Southwick ◽  
Belinda Ostrowsky ◽  

About 55% of U.S. Candida auris clinical cases were reported from New York and New Jersey from 2016 through 2020. Nearly all New York-New Jersey clinical isolates (99.8%) were fluconazole resistant, and 50% were amphotericin B resistant. Echinocandin resistance increased from 0% to 4% and pan-resistance increased from 0 to <1% for New York C. auris clinical isolates but not for New Jersey, highlighting the regional differences.

mSphere ◽  
2022 ◽  
Ruixi Chen ◽  
Rachel A. Cheng ◽  
Martin Wiedmann ◽  
Renato H. Orsi

Not all Salmonella isolates are equally likely to cause human disease, and Salmonella control strategies may unintentionally focus on serovars and subtypes with high prevalence in source populations but are rarely associated with human clinical illness. We describe a framework leveraging WGS data in the NCBI PD database to identify Salmonella subtypes over- and underrepresented among human clinical cases.

2022 ◽  
Vol 7 (1) ◽  
pp. 98-101
Lean Heong Foo ◽  
Marianne Meng Ann Ong

Introduction: Team-based learning (TBL) pedagogy is a structured, flipped classroom approach to promote active learning. In April 2019, we designed a TBL workshop to introduce the New Classification of Periodontal Diseases 2017 to a group of general dental practitioners (GDPs). We aimed to investigate GDPs feedback on learning this new classification using TBL pedagogy. Methods: Two articles related to the 2017 classification were sent to 22 GDPs 2 weeks prior to a 3-hour workshop. During the face-to-face session, they were randomly assigned to five groups. They participated in individual and group readiness assurance tests. Subsequently, the GDPs had inter- and intragroup facilitated discussions on three simulated clinical cases. They then provided feedback using a pen-to-paper survey. Based on a 5-point Likert scale (1-strongly disagree to 5-strongly agree), they indicated their level of agreement on items related to the workshop and their learning experience. Results: Majority (94.7%, 18 out of 19 GDPs) agreed the session improved their understanding of the new classification and they preferred this TBL pedagogy compared to a conventional lecture. All learners agreed they can apply the knowledge to their work and there was a high degree of participation and involvement during the session. They found the group discussion and the simulated clinical cases useful. Conclusion: A TBL workshop is suitable for clinical teaching of the New Classification of Periodontal Diseases 2017 for GDPs. Its structure promotes interaction among learners with the opportunity to provide feedback and reflection during the group discussions. This model might be a good pedagogy for continuing dental education.

S. N. Stjazhkina ◽  
I. V. Kotova ◽  
M. F. Zarivchatsky ◽  
T. E. Chernysheva ◽  
A. V. Ledneva ◽  

Aim: To identify a connection between acute and chronic pancreatitis and primary hyperparathyroidism on the base of clinical cases. To consider the features of the diagnosis and treatment of acute and chronic pancreatitis with primary hyperparathyroidism.Materials and methods: Over the past 10 years, there have been observed 3 cases of pancreatitis with primary hyperparathyroidism. Two patients were diagnosed with chronic pancreatitis, one patient was diagnosed with acute destructive pancreatitis. Patients were undergoing surgery, parathyroidectomy was performed.Results: Primary hyperparathyroidism is rarely associated with the occurrence of acute or chronic pancreatitis, but hypercalcemia plays an important role in the pathogenesis of these diseases. Pancreatitis usually occurs in the late stage of hyperparathyroidism, which explains the low prevalence of this association in developed countries, where primary hyperparathyroidism is diagnosed at an early stage of the disease.Conclusion: These clinical cases of radical surgical treatment of parathyroid adenoma associated with severe concomitant pathology testifies to the effectiveness of the surgical method in some cases. It is necessary to take into account severe concomitant pathology and diagnose and correct it in time.

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