Study of growth and biosynthetic features of saprophytic Claviceps purpurea lines in submerged culture

Author(s):  
R.I. Bobyleva ◽  
N.S. Tsybulko
1969 ◽  
Vol 18 (3) ◽  
pp. 464-468
Author(s):  
A. M. Amici ◽  
A. Minghetti ◽  
T. ScottI ◽  
C. Spalla ◽  
L. Tognoli

1977 ◽  
Vol 23 (5) ◽  
pp. 596-600 ◽  
Author(s):  
Z. ↠eháček ◽  
J. D. Desai ◽  
P. Sajdl ◽  
S. Pažoutová

Asparagine was a superior nitrogen source for clavine-alkaloid production in Claviceps purpurea. Its transport into the cell exceeded the cell's biosynthetic need for this amino acid. Asparagine entered the cell without degradation. This disturbed the relative pool sizes of various amino acids resulting in a change in the genetically determined ratio at which amino acids were utilized for protein synthesis. Overproduction of alkaloids (4500 μg.ml−1) may be associated with increased availability of tryptophan because of the enhanced assimilation of asparagine-derived ammonia via glutamine synthetase (EC 6.3.1.2). However, ammonium salts in the fermentation broth led to a depression of the alkaloid yield. Partial replacement of the ammonium salt by aspartic acid elevated alkaloid production.


1969 ◽  
Vol 18 (3) ◽  
pp. 464-468 ◽  
Author(s):  
A. M. Amici ◽  
A. Minghetti ◽  
T. ScottI ◽  
C. Spalla ◽  
L. Tognoli

1967 ◽  
Vol 15 (3) ◽  
pp. 597-602 ◽  
Author(s):  
Alba M. Amici ◽  
A. Minghetti ◽  
T. Scotti ◽  
C. Spalla ◽  
L. Tognoli

1967 ◽  
Vol 15 (3) ◽  
pp. 597-602
Author(s):  
Alba M. Amici ◽  
A. Minghetti ◽  
T. Scotti ◽  
C. Spalla ◽  
L. Tognoli

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
LM Papaspyridi ◽  
E Topakas ◽  
N Aligiannis ◽  
P Christakopoulos ◽  
AL Skaltsounis ◽  
...  

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