Relationship between Exhaled Nitric Oxide and Exposure to Low-Level Environmental Tobacco Smoke in Children with Asthma on Inhaled Corticosteroids

2012 ◽  
Vol 49 (7) ◽  
pp. 673-678 ◽  
Author(s):  
Elizabeth de la Riva-Velasco ◽  
Sankaran Krishnan ◽  
Allen J. Dozor
Keyword(s):  
Nitric Oxide ◽  
Environmental Tobacco Smoke ◽  
Tobacco Smoke ◽  
Inhaled Corticosteroids ◽  
Exhaled Nitric Oxide ◽  
Low Level ◽  
Children With Asthma

scholarly journals Spirometric changes in children with asthma exposed to environmental tobacco smoke and treated with inhaled corticosteroids

2019 ◽  
Vol 76 (3) ◽  
pp. 321-330
Author(s):  
Snezana Radic ◽  
Branislava Milenkovic ◽  
Branislav Gvozdenovic ◽  
Biljana Medjo ◽  
Sanja Dimic-Janjic
Keyword(s):  
Lung Function ◽  
Fluticasone Propionate ◽  
Environmental Tobacco Smoke ◽  
Tobacco Smoke ◽  
Inhaled Corticosteroids ◽  
Persistent Asthma ◽  
Forced Expiratory Volume ◽  
The Family ◽  
Lower Lung ◽  
Children With Asthma

Background/Aim. Corticosteroids are the most frequently prescribed anti-inflammatory treatment in asthma. A purpose of this study was to compare the spirometric parameters as a response to inhaled fluticasone propionate (FP) treatment in children with asthma, exposed and nonexposed to environmental tobacco smoke (ETS). Methods. The study included 527 children aged between 1 and 16 years with persistent asthma divided into the groups of ETS exposed (ETSE, n = 337) and ETS free (ETSF, n = 190) children. Spirometry was performed before (1st set of results) and after 6 months of FP treatment (2nd set of results). Good lung function (GLF) was defined as forced expiratory volume in one second (FEV1) ? 85%, and ?poor lung function? (PLF) as FEV1 < 85%. Results. Among the ETSE children, 208 had one smoking parent, 129 had two, 228 had smoking mothers and 238 smoking fathers. The ETSE children received a higher FP dose (p < 0.0001) which was increased with the increase of the number of smokers in the family. The ETSE children had significantly lower lung function both in the 1st and 2nd sets of tests compared to the ETSF children (p < 0.05). After the FP treatment, both groups improved all spirometric parameters (p < 0.001). In the 2nd set of the spirometric tests, the children of smoking mothers had lower spirometry values compared to the children of smoking fathers (p < 0.05). The proportion of the children improving from the PLF to GLF after 6 months of FP was much higher among the ETSF than the ETSE children (p < 0.05). Conclusions. The ETSE children had lower spirometric values before FP. After 6-months of the FP treatment children in both groups improved the spirometric values, but the improvement was higher in the ETSF children.

scholarly journals PD51 - Children with asthma exposed to Environmental Tobacco Smoke (ETS) and inhaled corticosteroids treatment

2014 ◽  
Vol 4 (S1) ◽  
Author(s):  
Snezana Radic ◽  
Zorica Zivkovic ◽  
Branislav Gvozdenovic ◽  
Sofija Cerovic ◽  
Olivera Calovic ◽  
...  
Keyword(s):  
Environmental Tobacco Smoke ◽  
Tobacco Smoke ◽  
Inhaled Corticosteroids ◽  
Children With Asthma

Immediate Effects of Environmental Tobacco Smoke on Exhaled Nitric Oxide and Lung Mechanics in Passive Smokers

CHEST Journal ◽  
2010 ◽  
Vol 138 (4) ◽  
pp. 577A
Author(s):  
Nektarios Anagnostopoulos ◽  
Marios S. Kougias ◽  
Constantine I. Vardavas ◽  
Irene Avlonitou ◽  
Vassiliki Evangelopoulou ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Environmental Tobacco Smoke ◽  
Tobacco Smoke ◽  
Exhaled Nitric Oxide ◽  
Lung Mechanics

scholarly journals Effects of the Indoor Environment on the Fraction of Exhaled Nitric Oxide in School-Aged Children

2009 ◽  
Vol 16 (3) ◽  
pp. e18-e23 ◽  
Author(s):  
Thomas A Kovesi ◽  
Robert E Dales
Keyword(s):  
Nitric Oxide ◽  
Airway Inflammation ◽  
Environmental Tobacco Smoke ◽  
Tobacco Smoke ◽  
Community Sample ◽  
Environmental Exposures ◽  
Exhaled Nitric Oxide ◽  
Hot Water ◽  
Tobacco Smoke Exposure ◽  
Healthy Children

BACKGROUND: The fractional concentration of exhaled nitric oxide (FeNO) appears to be a good marker for airway inflammation in children with asthma.OBJECTIVE: To evaluate the effect of environmental exposures on exhaled nitric oxide in a community sample of children.METHODS: The relationship among exhaled nitric oxide, underlying disease and home environmental exposures was examined using questionnaire data and measurement of exhaled nitric oxide in a cross-sectional study of 1135 children that included healthy children, and children with allergies and/or asthma who were attending grades 4 through 6 in Windsor, Ontario.RESULTS: Among healthy children, there was a positive association between FeNO and occupancy (P<0.02). Compared with forced air and hot water radiant heat, electric baseboard heating was associated with a significant increase of FeNO in healthy children (P=0.007) and children with allergies (P=0.043). FeNO was not associated with environmental tobacco smoke exposure or reported surface mold. The presence of pet dog(s), but not cats, was associated with a significantly lower FeNO in healthy children (P<0.001) and in children with reported allergies (P<0.001).CONCLUSIONS: The type of heating system, but not previously reported environmental tobacco smoke or mold exposure appears to affect exhaled nitric oxide in children. Exposure to different types of pets may have disparate effects on airway inflammation.

scholarly journals The STOPPA Twin Study Explains the Exhaled Nitric Oxide and Asthma Link by Genetics and Sensitization

2017 ◽  
Vol 20 (4) ◽  
pp. 330-337
Author(s):  
Björn Nordlund ◽  
Cecilia Lundholm ◽  
Vilhelmina Ullemar ◽  
Marianne van Hage ◽  
Anne K. Örtqvist ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Inhaled Corticosteroids ◽  
Population Based ◽  
Exhaled Nitric Oxide ◽  
Regression Coefficients ◽  
Parental Report ◽  
Children With Asthma ◽  
Genetic And Environmental Factors ◽  
Airborne Allergens ◽  
Shared Genetic

Background: The link between asthma and exhaled nitric oxide (FENO) is not completely understood. The aim of this study was to estimate the association between FENO and asthma, taking genetics, sensitization, and inhaled corticosteroids (ICS) into account. Methods: A total of 681 twins (53% monozygotic [MZ] and 47% dizygotic [DZ]) from the population-based STOPPA study (mean age 12.6 years) were recruited and information on FENO (parts per billion), parental report of current asthma, sensitization to airborne allergens (Phadiatop; IgE ≥0.35 kUA/l), and ICS-treatment was collected. We estimated the association between FENO and asthma, sensitization, and ICS in all twins and within pairs (DZ and MZ) to address shared genetic and environmental factors. Linear regression of log-transformed FENO was used and results presented as exponentiated regression coefficients (exp[β]), with 95% confidence interval (CI). Results: We found an association between asthma and FENO in all twins, exp(β) 1.31 [1.11, 1.54]. In within-pairs analysis, the association was stronger within DZ pairs discordant for FENO, exp(β) 1.50 [1.19, 1.89], compared to MZ pairs, exp(β) 1.07 [0.84, 1.37], p = .049. There was no difference in FENO in non-sensitized children with asthma, compared to children with neither asthma nor sensitization, exp(β) 0.89 [0.77, 1.03]. However, increased FENO was associated with sensitization, exp(β) 1.48 [1.30, 1.69], and with sensitization together with asthma, exp(β) 1.98 [1.57, 2.51], in all twins and within DZ pairs discordant for FENO, but not in MZ pairs. The FENO asthma association remained in DZ pairs without regular ICS-treatment. Conclusions: The association between FENO and asthma is explained by genetics and sensitization.

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